DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Grik and grin2bb

DIOPT Version :9

Sequence 1:	NP_001262788.1	Gene:	Grik / 42476	FlyBaseID:	FBgn0038840	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	NP_001121809.1	Gene:	grin2bb / 559976	ZFINID:	ZDB-GENE-061207-27	Length:	1770	Species:	Danio rerio

Alignment Length:	1047	Identity:	217/1047 - (20%)
Similarity:	395/1047 - (37%)	Gaps:	272/1047 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 FVKMISTEASFPLGFILTSLLLA---FPGCRGERTNVGLVYENTDPDLEKIF---HL---AISKA 58
            ||.::|   ||.|...::.|||:   ||.|...|.. |:.......:.:.|.   |.   .:|..
Zfish    37 FVSLVS---SFKLPLYISLLLLSLFFFPTCESRRGG-GIGTPTGGMNSQSIISPPHYPPPGVSPV 97

  Fly    59 NEENEDLQLHGVSVS-IEPGNSFETS---------------------------------KKLCKM 89
            ..........|:|:: |..|||.|.|                                 .::|.:
Zfish    98 GPPMSPKFAQGLSIAVILVGNSSEVSLSEGLEKEDFLHVPLPPKVELVTMNETDPKSIINRICAL 162

  Fly    90 LRQNLV--AVFGPTSNLAARHAMSICDAKELPFLDTRWDFGAQ-LPTINLHPHPATLGVALRDMV 151
            :.:|.:  .|||.                     ||..:..|| |..|:...|...||:.....:
Zfish   163 MSRNWLQGVVFGD---------------------DTDQEAIAQILDFISAQTHIPILGIRGGSSM 206

  Fly   152 VALGWESFTIIYESGEYLPTVRE-------LLQMYGTAGPTVTVRRYELDLNGNYRNVLRRIRNA 209
            :....:..::.::.|   |::.:       :::.|.....::....|.     .:::.:.|||:.
Zfish   207 IMAAKDDHSMFFQFG---PSIEQQASVMLNIMEEYDWYIFSIVTTYYP-----GHQDFVNRIRST 263

  Fly   210 DDFSFV-------------------------------VVGSMATLPE---FFKQAQQVGLVTSDY 240
            .|.|||                               |:....|..|   .|:.|..|||....|
Zfish   264 VDNSFVGWELEEVLLLDMSVDDGDSKIQNQMKKLQSPVILLYCTKEEATTIFEVAHSVGLTGYGY 328

  Fly   241 RYIIGNLDWHTMDLEPYQHAGTNI--TGLRLVSPDSEQVQEVAKALYESEEPFQNVSCPLTNSMA 303
            .:|:.:|.....|..|      |:  |||..||.|...        |..|              |
Zfish   329 TWIVPSLVAGDTDNVP------NVFPTGLISVSYDEWD--------YGLE--------------A 365

  Fly   304 LVYDGVQLLA--------ETYKHVNFRPVALSCNDDSAWDKG--YTLVNYMKSLTLNGLTGPIRF 358
            .|.|.|.::|        :...|...:.......|......|  ..::.|:.::|..|..  :.|
Zfish   366 RVRDAVAIIAMATSTMMLDRGPHTLLKSGCHGAPDKKGSKSGNPNEVLRYLMNVTFEGRN--LSF 428

  Fly   359 DYEGLRTDFKLEVIELAVSGM-QKIGQWSGEDGFQENRPAPAHSLEPDMRSLVNKSFVVITAISE 422
            ..:|.:...||.:|.|..... :::|:|.......:....|...|..|.....:....::|....
Zfish   429 SEDGFQMHPKLVIILLNKERQYERVGKWENGSLAMKYHVWPRFELYSDAEEREDDHLSIVTLEEA 493

  Fly   423 PYGMLKETS-------------------EKLEGNDQF------EGFGIELIDELSKKLGFSYTWR 462
            |:.::::..                   :.|.|:...      :||.|:::.:::|.:.|:|...
Zfish   494 PFVIVEDVDPLSGTCMRNTVPCRKQLKLQNLTGDSGIYIKRCCKGFCIDILKKIAKSVKFTYDLY 558

  Fly   463 LQEDNKYGGIDPKTGEWNGMLREIIDSRADMGITDLTMTSERESGVDFTIPFMSLGIGILF-RKP 526
            |..:.|:|  ....|.||||:.|::...|.|.:..||:..||...:||::||:..||.::. |..
Zfish   559 LVTNGKHG--KKINGTWNGMVGEVVLKNAHMAVGSLTINEERSEVIDFSVPFIETGISVMVSRSN 621

  Fly   527 MKEPPKLFSFMSPFSGEVWLWLGLAYMGVS-ISMFVLGRLSPAEWDNPYPCIEEPTELEN-QFSF 589
            ....|.  :|:.|||.:||:.:.:..:.|| :::||....||..::.   |:.:..|... .|:.
Zfish   622 GTVSPS--AFLEPFSADVWVMMFVMLLIVSAVAVFVFEYFSPVGYNR---CLADGREPGGPSFTI 681

  Fly   590 ANCLWFSIGALLQQGSELA-PKAYSTRAVAASWWFFTLILVSSYTANLAAFLTVESL---VTPIN 650
            ...:|...|.:......:. ||..:::.:.:.|.||.:|.::|||||||||:..|..   ||.::
Zfish   682 GKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEYVDQVTGLS 746

  Fly   651 D-----ADDLSKNKGGVNYGAKIGGATFNFFKESNYPTYQRMYEFMRDNPQYMTNTNQEGVDRVE 710
            |     .:|.|.   ...:|....|:|....:.:    |:.|:       .|||:.:|:.|:...
Zfish   747 DKKFQHPNDFSP---PFRFGTVPNGSTERNIRNN----YKEMH-------SYMTSFHQKNVNEAL 797

  Fly   711 NSNY-----AFLMESTTIEYITER--RCTLTQVGA--LLDEKGYGIAMRKNWPYRDTLSQAVLEM 766
            :|..     ||:.::..:.|:..|  .|.|..:|:  :....|||||::|:..::..:..|:|::
Zfish   798 HSLKSGKLDAFIYDAAVLNYMAGRDEGCKLVTIGSGYIFATTGYGIAIQKDSGWKRAVDLAILQL 862

  Fly   767 QEQGLLTKMKTKWWQEKRGGGACSDADEDSGAVALEISNLGGVFLVMGVGSFFGIFVSLLEMVLG 831
            ...|.:.:::..|..     |.|.:...:..:..|::.|:.|||.::|..           |.|.
Zfish   863 FGDGEMEELEALWLT-----GICHNEKNEVMSSQLDVDNMAGVFYMLGAA-----------MALS 911

  Fly   832 VKERSDENQVSFKTELLD--EIRFILQ--CSGN--------------TKAVKYPKNSSRSNASSK 878
            :        ::|..|.|.  ::||...  |||.              ...|:..:|.|..|:.|.
Zfish   912 L--------ITFIAEHLFYWQLRFCFMGVCSGKPGMTFSISRGIYSCIHGVQIEENKSALNSPSA 968

  Fly   879 SKGSSMS 885
            :...:|:
Zfish   969 TMKMNMN 975

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Grik	NP_001262788.1	PBP1_iGluR_Kainate	37..391	CDD:107377	78/450 (17%)
		ANF_receptor	53..374	CDD:279440	72/413 (17%)
		Periplasmic_Binding_Protein_Type_2	411..781	CDD:304360	99/415 (24%)
		Lig_chan	543..816	CDD:278489	70/292 (24%)
grin2bb	NP_001121809.1	PBP1_iGluR_NMDA_NR2	107..470	CDD:107373	74/421 (18%)
		ANF_receptor	138..442	CDD:279440	62/362 (17%)
		PBP2_iGluR_NMDA_Nr2	482..882	CDD:270436	101/425 (24%)
		Lig_chan	636..908	CDD:278489	70/304 (23%)
		NMDAR2_C	919..1770	CDD:287527	12/57 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591266
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840