DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Grik and grid1b

DIOPT Version :9

Sequence 1:	NP_001262788.1	Gene:	Grik / 42476	FlyBaseID:	FBgn0038840	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	XP_009304811.1	Gene:	grid1b / 557511	ZFINID:	ZDB-GENE-121214-84	Length:	1048	Species:	Danio rerio

Alignment Length:	865	Identity:	241/865 - (27%)
Similarity:	414/865 - (47%)	Gaps:	104/865 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 NVGLVYENTDPDLEKIFHLAISKANEENEDLQLHGVSVS---IEPGNSFETSKKLCKMLRQNLVA 96
            ::|.::|......:::|.||||..:..::.||...::.|   |||.|.|:..::.|:::.|.::|
Zfish    25 HIGAIFEENAARDDEVFQLAISDLSLNDDILQSEKITHSIKYIEPNNPFQAVQEACELMTQGILA 89

  Fly    97 VFGPTSNLAARHAMSICDAKELPFLDTRWDF-GAQLPTINLHPH------------PATLGVALR 148
            :...|...:|....|:.||..:|.|..:.:. |:......|:|.            |..||..:.
Zfish    90 LVTSTGCASASALQSLTDAMHIPHLYVQRNAEGSPRTACQLNPSPDGERYTLAARPPVRLGDVML 154

  Fly   149 DMVVALGWESFTIIYESGEYLPTVRELLQMYGTAGPTVTVRRYELDLNG---------------N 198
            .:|..|.|:.|.:.|:|...:..::..|......|..|:::|.:.:::|               .
Zfish   155 TLVGELRWQKFIVFYDSDYDIRGLQVFLDQTSRQGLDVSLQRVDRNISGVFSSLFTSMRTEELNR 219

  Fly   199 YRNVLRRIRNADDFSFVVVGSMATLPEFFKQAQQVGLVTSDYRYIIGNLDWHTMDLEPYQHAGT- 262
            ||:.|||.        :::.|......|..||.:..|.:.|..::..|.:....::....|:..
Zfish   220 YRDTLRRA--------ILLLSPRGAQVFIHQAVETNLASKDSHWVFVNEEISDTEILELAHSSLG 276

  Fly   263 NITGLRLVSP---DS-----EQVQEVAKALYESEEPFQNVSCPLTNSMALVYDGVQLLAET-YKH 318
            .:|.:|.:.|   ||     .....::..|.:.:|.:..   .|..|...:||.|.:||.. |:.
Zfish   277 RMTVVRQIFPLWRDSSVSCMRNSHRISSLLCDPQEGYLQ---SLEVSNLYLYDSVLMLANAFYRK 338

  Fly   319 VNFRP----VALSC--NDDSAWDKGYTLVNYMKSLTLNGLTGPIRFDYEGLRTDFKLEVIELAVS 377
            :..|.    .:|:|  .....|:.|::::..::...:.||||.:.|...|..:..:.|::..:.|
Zfish   339 LEDRKWHSMASLNCIRKSTKPWNGGWSMLETIQKGRITGLTGIMDFMENGSNSHVQFEILGTSFS 403

  Fly   378 -----GMQKIGQWSGEDG----FQENRPAPAHSLEPDMRSLVNKSFVVITAISEPYGMLKETSEK 433
                 .::::..|....|    .:|:|      :|..|:.:..|   |:|.:.:|:.|:   :|.
Zfish   404 ETFGKDIKRLATWDSVHGLNGSLKESR------IENGMQGVTVK---VVTLLEDPFVMV---AEN 456

  Fly   434 LEGN-DQFEGFGIELIDELSKKLGFSYTWRLQEDNKYGGIDPKTGEWNGMLREIIDSRADMGITD 497
            :.|. .:::||.|::::.|:|.|||.|......|:|||. ....|.||||:.|:|:.|||:.::.
Zfish   457 ILGQPKRYKGFSIDVLEALAKILGFKYDIYQVADSKYGS-QLSNGSWNGMIGELINKRADLAVSA 520

  Fly   498 LTMTSERESGVDFTIPFMSLGIGILFRKPMKEPPKLFSFMSPFSGEVWLWLGLAYMGVSISMFVL 562
            :|:|.|||:.|||:..:|...:|||.||| :|...:||..:||...||..:..|...|.:.:|:|
Zfish   521 ITITPERENVVDFSKRYMDYSVGILHRKP-EEKINIFSLFAPFDLAVWACIAAAIPVVGVLIFLL 584

  Fly   563 GRLSPAEWDNPYPCIEEPTELENQFSFANCLWFSIGALLQQGSELAPKAYSTRAVAASWWFFTLI 627
            .|:......|| |.....:.:.|  |..:.:|...||.:|||.:....:.:.|.|..|||.||||
Zfish   585 TRMQMLRSQNP-PGAHHASSMSN--SLHSAIWIVYGAFVQQGGDSVVGSVALRIVMGSWWLFTLI 646

  Fly   628 LVSSYTANLAAFLTVESLVTPINDADDLSKNKGGVNYGAKIGGATFNFFK-ESNYP-----TYQR 686
            :.|||||||||||||..:...|....||::.. ...||.....|.:::|| :...|     ||..
Zfish   647 VCSSYTANLAAFLTVSRMDNTIRTFQDLARQM-DFAYGTVRDSAVYDYFKAKGTNPLEQDSTYAE 710

  Fly   687 MYEFMRDN--PQYMTNTNQEGVDRVENSNYAFLMESTTIEY--ITERRCTLTQVGALLDEKGYGI 747
            ::..:..|  ..:..::..||:.:.:...||||.:...:||  :|:..||:|..|..:..|||||
Zfish   711 LWRTISKNNGQDFSVSSPSEGIRKAKKGPYAFLWDMAVVEYAALTDDDCTITVSGNSMSSKGYGI 775

  Fly   748 AMRKNWPYRDTLSQAVLEMQEQGLLTKMKTKWWQEKRGGGACSDADEDSGAV----ALEISNLGG 808
            ||:...||||.:||.:||:||:|.|..:|.|||...   |.| |.:..|.|.    :|::.:..|
Zfish   776 AMQHGSPYRDLISQKILELQEKGDLDVLKQKWWPRT---GRC-DLNSHSNAQPDGRSLKLHSFAG 836

  Fly   809 VFLVMGVGSFFGIFVSLLEM 828
            ||.::..|......|:.|||
Zfish   837 VFCILAAGLLLACLVAALEM 856

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Grik	NP_001262788.1	PBP1_iGluR_Kainate	37..391	CDD:107377	85/409 (21%)
		ANF_receptor	53..374	CDD:279440	79/367 (22%)
		Periplasmic_Binding_Protein_Type_2	411..781	CDD:304360	137/380 (36%)
		Lig_chan	543..816	CDD:278489	97/286 (34%)
grid1b	XP_009304811.1	PBP1_iGluR_delta_1	25..424	CDD:107387	85/409 (21%)
		ANF_receptor	36..400	CDD:279440	80/374 (21%)
		Periplasmic_Binding_Protein_Type_2	437..809	CDD:304360	137/383 (36%)
		Lig_chan	565..840	CDD:278489	97/282 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591110
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.840