DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Grik and grik4

DIOPT Version :9

Sequence 1:	NP_001262788.1	Gene:	Grik / 42476	FlyBaseID:	FBgn0038840	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	XP_021322087.1	Gene:	grik4 / 556582	ZFINID:	ZDB-GENE-070821-5	Length:	965	Species:	Danio rerio

Alignment Length:	927	Identity:	313/927 - (33%)
Similarity:	507/927 - (54%)	Gaps:	67/927 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MWFVKMISTEASFPLGFILTSLLLAFPGC-RGERTNVGLVYENTDPDLEKIFHLAISKANEENED 64
            ||    :....|.||.|.:.::|.....| ||||..:.|..:            :|::::..:..
Zfish    13 MW----VRNATSGPLSFRIAAILDDPMECSRGERLAITLAKD------------SINRSSNRSTT 61

  Fly    65 LQLHGVSVSIEPGNSFETSKKLCKMLRQNLVAVFGPTSNLAARHAMS-ICDAKELPFLDTRWD-- 126
            .:|......:...:.:||.:.:|:::.:.:|||.||:::.|:...:| ||..||:|::....:
Zfish    62 GKLEVDIFELLRDSEYETGETMCQIMSKGVVAVLGPSASPASNSIISNICGEKEVPYVKVAPEDI 126

  Fly   127 FGAQLP---TINLHPHPATLGVALRDMVVALGWESFTIIYESGEYLPTVRELLQMYGTAGPTVTV 188
            ...|.|   |::|.|....:.:|:..::......:..:|....:.|..:..||:.:..:..|::|
Zfish   127 LKVQFPRFTTLDLRPTNTDISMAVAGLLTFFNSSTSCLICAQADCLLNLEVLLRQFLISKETLSV 191

  Fly   189 RRYELDLNGNYRNVLRRIRNADDFSFVVVGSMATLPE-FFKQAQQVGLVTSDYRYIIGNLDWHTM 252
            |.  ||.:.:...:|:.||: |..:.::|.:.||:.. ..::|.::|:::..|.||:.:|::..:
Zfish   192 RM--LDDSQDPTPLLKEIRD-DKTATIIVDANATMSHVILERASELGMLSVYYTYILTSLEFSLL 253

  Fly   253 DLEPYQHAGTNITGLRLVSPDSEQVQEVAKALYES------EEPFQNVSCPLTNSMALVYDGVQL 311
            .|:.......||.|..:.:......|:...:|..|      ..||  ...||  |.||::|.|..
Zfish   254 RLDDLADQRVNIVGFSVFNRTHPFFQDFVLSLNRSWQENCDHAPF--AGTPL--SSALLFDAVHT 314

  Fly   312 LA----ETYKHVNFRPVALSCNDDSAWDKGYTLVNYMKSLTLNGLTGPIRFDYEGLRTDFKLEVI 372
            :.    |..:..|.....|||.....|:.|.:|:||::.:.|.||||.|.|:.:|.|:::.|.::
Zfish   315 VVAAVQELNRSQNVGATQLSCKSSKIWEHGTSLMNYLRMVELEGLTGHIEFNSKGQRSNYALRIM 379

  Fly   373 ELAVSGMQKIGQWSGEDGFQENRPAPAHSLEPDMRSLVNKSFVVITAISEPYGMLKETSEKLEGN 437
            :.:..|:::||||..|.|....|..|:.::..   :|.|.:..:.|.:..||.||:...::||||
Zfish   380 QNSRDGLRQIGQWHSEQGLSMERKLPSLNVTD---TLFNTTLTITTILENPYVMLRANHQELEGN 441

  Fly   438 DQFEGFGIELIDELSKKLGFSYTWRLQEDNKYGGIDPKTGEWNGMLREIIDSRADMGITDLTMTS 502
            |::|||.::::.||:..|.|.|..||..|..| |:....|.|.||:.|:|..:||:.:..||:|:
Zfish   442 DRYEGFCVDMLKELADILKFKYRIRLVGDGVY-GVPGANGTWTGMVGELISRKADLAVAALTITA 505

  Fly   503 ERESGVDFTIPFMSLGIGILFRKPMKEPPKLFSFMSPFSGEVWLWLGLAYMGVSISMFVLGRLSP 567
            |||..:||:.|||:|||.|::|..:...|..|||:.|||..|||::.|||:.||..:|::.||:|
Zfish   506 EREKVIDFSKPFMTLGISIMYRVHIGRRPGYFSFLDPFSPGVWLFMLLAYLAVSCVLFLVARLTP 570

  Fly   568 AEWDNPYPCIE-EPTELENQFSFANCLWFSIGALLQQGSELAPKAYSTRAVAASWWFFTLILVSS 631
            .||.||:||:: ..:.|.||:|..|..||.:|..:||||.:||:|.|||.|:..||.||||::||
Zfish   571 YEWYNPHPCLKGRCSLLINQYSLGNSFWFPVGGFMQQGSTIAPRALSTRCVSGVWWAFTLIIISS 635

  Fly   632 YTANLAAFLTVESLVTPINDADDLSKNKGGVNYGAKIGGATFNFFKESNYPTYQRMYEFM-RDNP 695
            |||||||||||:.:..||...|||: ::..:.||...||:|..||:.|.|.|||||:.|| ...|
Zfish   636 YTANLAAFLTVQRMEVPIESVDDLA-DQTAIEYGTMHGGSTMTFFQNSRYQTYQRMWNFMYSKQP 699

  Fly   696 QYMTNTNQEGVDRVENSNYAFLMESTTIEYITERRCTLTQVGALLDEKGYGIAMRKNWPYRDTLS 760
            .....:.:||:.||.|||||:|:|||..||..:|.|.|||:|.|||.|||||.|.....|||...
Zfish   700 SVFVKSTEEGIARVLNSNYAYLLESTMNEYYRQRNCNLTQIGGLLDTKGYGIGMPLGSVYRDEFD 764

  Fly   761 QAVLEMQEQGLLTKMKTKWWQEKRGGGACSDADEDSGAVALEISNLGGVFLVMGVGSFFGIFVSL 825
            .|:|.:||:..|..:|.|||.    ||.| ..:||..|..|.:.|:||:|:|:..|....||:::
Zfish   765 LAILRLQEENRLEILKRKWWD----GGKC-PKEEDHRAKGLGMENIGGIFVVLVCGLLVAIFMAV 824

  Fly   826 LEMVLGVKERSDENQVSFKTELLDEIRFILQCSGNTK-------AVKYP------KNSSRSNASS 877
            ||.|..:: .:...::|...|:|.|::.|:.|..:.:       :|..|      :..:|:.|:|
Zfish   825 LEFVWMLR-HTPGTELSVCEEMLRELQGIVLCQDSLQLRRRRGASVLRPQPLPLDERRARAAAAS 888

  Fly   878 KSKGSSMSVDSLPEDTS 894
            .|.|...:...|.|..|
Zfish   889 LSNGKLCTGTGLSEPLS 905

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Grik	NP_001262788.1	PBP1_iGluR_Kainate	37..391	CDD:107377	88/370 (24%)
		ANF_receptor	53..374	CDD:279440	81/337 (24%)
		Periplasmic_Binding_Protein_Type_2	411..781	CDD:304360	174/371 (47%)
		Lig_chan	543..816	CDD:278489	132/274 (48%)
grik4	XP_021322087.1	Periplasmic_Binding_Protein_Type_1	26..400	CDD:324556	95/392 (24%)
grik4	XP_021322087.1	PBP2_iGluR_kainate_KA1	425..785	CDD:270442	172/361 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590962
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	1	1.010	-	-		D60688at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.860