DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Grik and grik2

DIOPT Version :9

Sequence 1:	NP_001262788.1	Gene:	Grik / 42476	FlyBaseID:	FBgn0038840	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	XP_021322472.1	Gene:	grik2 / 556013	ZFINID:	ZDB-GENE-080414-1	Length:	908	Species:	Danio rerio

Alignment Length:	879	Identity:	330/879 - (37%)
Similarity:	503/879 - (57%)	Gaps:	40/879 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 LGFILTSLLLAFPGCRGERTNVGLVYENTDPD----LEKIFHLAISKANEENEDLQLHGVSVSIE 75
            ||.:|..|.:.:..........|.::|:.:..    .|..|..|::..|.....|....::..|:
Zfish    17 LGLLLLLLCVGYSHGMPHVLRFGGIFESIESGPSGAEELAFKFALNTINRNRTLLPNTTLTYDIQ 81

  Fly    76 PGN---SFETSKKLCKMLRQNLVAVFGPTSNLAARHAMSICDAKELPFLDTRWDFGAQLPT---- 133
            ..|   |||.|:|.|..|...:.|:|||:.:.:|....|||:|..:|.:.|:|..  |:..
Zfish    82 RINIHDSFEASRKACDQLSLGVAAIFGPSHSSSANAVQSICNALGVPHIQTKWKH--QVSDNRDS 144

  Fly   134 --INLHPHPATLGVALRDMVVALGWESFTIIYESGEYLPTVRELLQMYGTAGPTVTVRRYELDLN 196
              :||:|..::|..|:.|:|....|::.|::|:....|..::||::........:.:|:...|..
Zfish   145 FYVNLYPDFSSLSRAILDLVHFFKWKTVTVVYDDSTGLIRLQELIKAPSRYNIRLKIRQLPADTK 209

  Fly   197 GNYRNVLRRIRNADDFSFVVVGSMATLPEFFKQAQQVGLVTSDYRYIIGNLDWHTMDLEPYQHAG 261
             :.:.:|:.::...:|..:............|||..:|::|..|.||...||...:|:|||:::|
Zfish   210 -DAKPLLKEMKRGKEFHVIFDCGHEMAAGILKQALAMGMMTEYYHYIFTTLDLFALDVEPYRYSG 273

  Fly   262 TNITGLRLVSPDSEQVQEVAKALYESEEPFQNVSCP--------LTNSMALVYDGVQLLA-ETYK 317
            .|:||.|:::.::.||..:.:..  |.|..|....|        :|...||:||.|.::| ...:
Zfish   274 VNMTGFRILNTENSQVSSIIEKW--SMERLQAPPKPDSGLLDGFMTTDAALMYDAVHVVAVAVQQ 336

  Fly   318 HVNFRPVALSCNDDSAWDKGYTLVNYMKSLTLNGLTGPIRFD-YEGLRTDFKLEVIELAVSGMQK 381
            .......:|.||....|..|...:..:|....:||||.|.|: ..||||||.|:||.|...|::|
Zfish   337 SPQITVSSLQCNRHKPWRFGNRFMTLIKEAHWDGLTGRINFNRTNGLRTDFDLDVISLKEEGLEK 401

  Fly   382 IGQWSGEDGFQ--ENRPAPAHSLEPDMRSLVNKSFVVITAISEPYGMLKETSEKLEGNDQFEGFG 444
            ||.|....|..  ||:.....::..   ||.|:|.||.|.:.|||.|.|::.:.|.|||:|||:.
Zfish   402 IGTWDPASGLNMTENQKGKTANVTD---SLSNRSLVVSTILEEPYVMFKKSDKPLYGNDRFEGYC 463

  Fly   445 IELIDELSKKLGFSYTWRLQEDNKYGGIDPKTGEWNGMLREIIDSRADMGITDLTMTSERESGVD 509
            ::|:.||:..|||.|..||.||.:||..|..:|:||||:||::|.:||:.:..|.:|..||..:|
Zfish   464 VDLLRELAAILGFGYELRLVEDGRYGAQDESSGQWNGMVRELMDHKADLAVAPLAITYVREKVID 528

  Fly   510 FTIPFMSLGIGILFRKPMKEPPKLFSFMSPFSGEVWLWLGLAYMGVSISMFVLGRLSPAEWDNPY 574
            |:.|||:|||.||:|||....|.:|||::|.|.::|:::.|||:|||..:||:.|.||.||.||:
Zfish   529 FSKPFMTLGISILYRKPNGTNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWYNPH 593

  Fly   575 PCIEEPTELENQFSFANCLWFSIGALLQQGSELAPKAYSTRAVAASWWFFTLILVSSYTANLAAF 639
            ||..:...:||.|:..|..||.:|||:||||||.|||.|||.|...|||||||::||||||||||
Zfish   594 PCNPDSDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAF 658

  Fly   640 LTVESLVTPINDADDLSKNKGGVNYGAKIGGATFNFFKESNYPTYQRMYEFMRD-NPQYMTNTNQ 703
            ||||.:.:||:.||||:| :..:.||....|:|..|||::...||.:|:|||.. ....|..:.:
Zfish   659 LTVERMESPIDSADDLAK-QTKIEYGVVEDGSTMTFFKKTKISTYDKMWEFMSSRRHSVMVKSIE 722

  Fly   704 EGVDRVENSNYAFLMESTTIEYITERRCTLTQVGALLDEKGYGIAMRKNWPYRDTLSQAVLEMQE 768
            ||::||..|:|||||||||||::|:|.|.|||:|.|:|.|.||:......||||.::.|:|::||
Zfish   723 EGIERVLTSDYAFLMESTTIEFVTQRNCNLTQIGGLIDSKAYGVGTPMGSPYRDKITIAILQLQE 787

  Fly   769 QGLLTKMKTKWWQEKRGGGACSDADEDSGAVALEISNLGGVFLVMGVGSFFGIFVSLLEMVLGVK 833
            :|.|..||.|||   ||.| |.: :|:..|.||.:.|:||:|:|:..|....:||::.|.:...|
Zfish   788 EGKLHMMKEKWW---RGNG-CPE-EENKEASALGVQNIGGIFIVLAAGLVLSVFVAVGEFLYKSK 847

  Fly   834 ERSDENQVSFKTELLDEIRFILQCSGNTKAVKYP 867
            :.:...:.||.:.::||:|..|:|....|....|
Zfish   848 QNAQLEKRSFCSAMVDELRVSLKCQRRLKHKPQP 881

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Grik	NP_001262788.1	PBP1_iGluR_Kainate	37..391	CDD:107377	105/376 (28%)
		ANF_receptor	53..374	CDD:279440	95/339 (28%)
		Periplasmic_Binding_Protein_Type_2	411..781	CDD:304360	188/370 (51%)
		Lig_chan	543..816	CDD:278489	138/273 (51%)
grik2	XP_021322472.1	PBP1_iGluR_Kainate	37..414	CDD:380605	106/381 (28%)
grik2	XP_021322472.1	Periplasmic_Binding_Protein_Type_2	430..800	CDD:419667	189/373 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591323
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	1	1.010	-	-		D60688at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.760