DRSC/TRiP Functional Genomics Resources

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Protein Alignment Grik and Gria3

DIOPT Version :9

Sequence 1:NP_001262788.1 Gene:Grik / 42476 FlyBaseID:FBgn0038840 Length:907 Species:Drosophila melanogaster
Sequence 2:NP_001268858.2 Gene:Gria3 / 53623 MGIID:95810 Length:888 Species:Mus musculus


Alignment Length:874 Identity:282/874 - (32%)
Similarity:457/874 - (52%) Gaps:78/874 - (8%)


- Green bases have known domain annotations that are detailed below.


  Fly    39 VYENTDPDLEKIFHLAISKANEENEDLQLHGVSVSIEPGNSFETSKKLCKMLRQNLVAVFGPTSN 103
            :|.......||.|||     |...:.|         :..|||..:...|....:.:.|:||....
Mouse    51 LYNTNQNTTEKPFHL-----NYHVDHL---------DSSNSFSVTNAFCSQFSRGVYAIFGFYDQ 101

  Fly   104 LAARHAMSICDAKELPFLDTRWDFGAQLPTINLHPHPATLGVALRDMVVALGWESFTIIYESGEY 168
            ::.....|.|.|....|:...:...|.:..: :...||..| |:..::....||.|..:|::...
Mouse   102 MSMNTLTSFCGALHTSFVTPSFPTDADVQFV-IQMRPALKG-AILSLLGYYKWEKFVYLYDTERG 164

  Fly   169 LPTVRELLQMYGTAGPTVTVRRYELDLNGN------YRNVLRRIRNADDFSFVVVGSMATLPEFF 227
            ...::.:::........||.|..     ||      :|.::..:....:..:::...:..:....
Mouse   165 FSILQAIMEAAVQNNWQVTARSV-----GNIKDIQEFRRIIEEMDRRQEKRYLIDCEVERINTIL 224

  Fly   228 KQAQQVGLVTSDYRYIIGNLDWHTMDLEPYQHAGTNITGLRLVSPDSEQVQEVAK---ALYESEE 289
            :|...:|..:..|.|::.||.:..:.||...|.|.||||.::|:.::..||:..:   .|.|.|.
Mouse   225 EQVVILGKHSRGYHYMLANLGFTDIVLERVMHGGANITGFQIVNNENPMVQQFIQRWVRLDEREF 289

  Fly   290 PFQNVSCPLTNSMALVYDGVQLLAETYKHVNFRPVALS---------CNDDSAWDKGYTLVNYMK 345
            | :..:.||..:.||.:|.:.::||.::::..:.|.:|         .|....|.:|..:...:|
Mouse   290 P-EAKNAPLKYTSALTHDAILVIAEAFRYLRRQRVDVSRRGSAGDCLANPAVPWSQGIDIERALK 353

  Fly   346 SLTLNGLTGPIRFDYEGLRTDFKLEVIELAVSGMQKIGQWSGEDGFQENRPAPAHSLEPDMRSLV 410
            .:.:.|:||.|:||..|.||::.::|.|:.|||.:|.|.|:..:.|.   |.....:..|..|..
Mouse   354 MVQVQGMTGNIQFDTYGRRTNYTIDVYEMKVSGSRKAGYWNEYERFV---PFSDQQISNDSSSSE 415

  Fly   411 NKSFVVITAISEPYGMLKETSEKLEGNDQFEGFGIELIDELSKKLGFSYTWRLQEDNKYGGIDPK 475
            |::.||.|.:..||.|.|:..|:||||:::||:.::|..|::|.:...|...:..|.|||..||:
Mouse   416 NRTIVVTTILESPYVMYKKNHEQLEGNERYEGYCVDLAYEIAKHVRIKYKLSIVGDGKYGARDPE 480

  Fly   476 TGEWNGMLREIIDSRADMGITDLTMTSERESGVDFTIPFMSLGIGILFRKPMKEPPKLFSFMSPF 540
            |..||||:.|::..|||:.:..||:|..||..:||:.|||||||.|:.:||.|..|.:|||:.|.
Mouse   481 TKIWNGMVGELVYGRADIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPL 545

  Fly   541 SGEVWLWLGLAYMGVSISMFVLGRLSPAEW---DNPYPCIEEPTELE------NQFSFANCLWFS 596
            :.|:|:.:..||:|||:.:|::.|.||.||   ||.    |||.:.:      |:|...|.||||
Mouse   546 AYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHLEDNN----EEPRDPQSPPDPPNEFGIFNSLWFS 606

  Fly   597 IGALLQQGSELAPKAYSTRAVAASWWFFTLILVSSYTANLAAFLTVESLVTPINDADDLSKNKGG 661
            :||.:|||.:::|::.|.|.|...|||||||::||||||||||||||.:|:||..|:||:| :..
Mouse   607 LGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAK-QTE 670

  Fly   662 VNYGAKIGGATFNFFKESNYPTYQRMYEFMRD-NPQYMTNTNQEGVDRVENS--NYAFLMESTTI 723
            :.||....|:|..||:.|....|::|:.:|:. .|...|.|..:||.||..|  .:|||:|||..
Mouse   671 IAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKSAEPSVFTKTTADGVARVRKSKGKFAFLLESTMN 735

  Fly   724 EYITERR-CTLTQVGALLDEKGYGIAMRKNWPYRDTLSQAVLEMQEQGLLTKMKTKWWQEKRGGG 787
            |||.:|: |...:||..||.||||:|..|....|..::.|||::.|||:|.|:|.|||.:|...|
Mouse   736 EYIEQRKPCDTMKVGGNLDSKGYGVATPKGSALRTPVNLAVLKLSEQGILDKLKNKWWYDKGECG 800

  Fly   788 ACSDADEDSGAVALEISNLGGVFLVMGVGSFFGIFVSLLEMVLGVKERSDENQVSFKTELLDEIR 852
            |.....:|..: ||.:||:.|||.::..|....:.|:|:|..  .|.|::..:            
Mouse   801 AKDSGSKDKTS-ALSLSNVAGVFYILVGGLGLAMMVALIEFC--YKSRAESKR------------ 850

  Fly   853 FILQCSGNTKAVKYPKNSSRSNASSKSKG 881
              ::.:.||:..|....::..|.::..:|
Mouse   851 --MKLTKNTQNFKPAPATNTQNYATYREG 877

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
GrikNP_001262788.1 PBP1_iGluR_Kainate 37..391 CDD:107377 85/369 (23%)
ANF_receptor 53..374 CDD:279440 73/338 (22%)
Periplasmic_Binding_Protein_Type_2 411..781 CDD:304360 170/382 (45%)
Lig_chan 543..816 CDD:278489 125/285 (44%)
Gria3NP_001268858.2 PBP1_iGluR_AMPA_GluR3 29..403 CDD:380610 87/376 (23%)
PBP2_iGluR_AMPA 416..799 CDD:270433 172/387 (44%)
Glutamate binding 502..504 0/1 (0%)