DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Grik and grin2da

DIOPT Version :9

Sequence 1:	NP_001262788.1	Gene:	Grik / 42476	FlyBaseID:	FBgn0038840	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	XP_009292354.1	Gene:	grin2da / 449864	ZFINID:	ZDB-GENE-041008-124	Length:	1916	Species:	Danio rerio

Alignment Length:	816	Identity:	185/816 - (22%)
Similarity:	334/816 - (40%)	Gaps:	176/816 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   169 LPTVRELLQMYG-TAGPTVTVRRYELDLNGNYRNVLRRIRNADDFSF-------VVVGSMATLP- 224
            |..:.|:|:.:. ||...||.|.:      .|.:.|..:....|.||       ||:.::...|
Zfish   203 LEVIFEVLEEFDWTAFSVVTTRHH------GYEDFLAMVEGMIDGSFIGWERKSVVMLNLTDDPG 261

  Fly   225 --------------------------EFFKQAQQVGLVTSDYRYIIGNLDWHTMDLEPYQHAGTN 263
                                      :.||.|...|..|..:.       |..:        |..
Zfish   262 GARTRRLLKENEAQVRLLYCSQEEAEQIFKAAWASGQATPSHM-------WFAV--------GPG 311

  Fly   264 ITGLRLVSPDSEQVQEVAKALYE------SEEPFQNVSCPLTNSMALVYDGVQLLAETYKHVNFR 322
            ::||.|        :.:.|||:.      .:||.:.::    ..::::..|...|...|......
Zfish   312 LSGLGL--------EGLPKALFAVRPQGWRDEPRRRIA----KGVSVLTHGAMALRREYGGARGT 364

  Fly   323 PVALSC-NDDSAWDKGYTLVNYMKSLTLNGLTGPIRFDYEGLRTDFKLEVIE-LAVSGMQKIGQW 385
            ..|.:| .|.:...:....:.:..::||:|  ....|:.:|...:..|:||. .|..|.:::|.|
Zfish   365 SFAGNCMMDGNQTQRVPGRIRFFSNITLSG--RDYSFNNDGYLANPLLDVISYTAGRGWEEVGWW 427

  Fly   386 SGEDGFQENRPAPAHSLEPDMR-----------SLVNKSFVVITAI----------SEPYGMLKE 429
              |:|....|..|.....|.::           :|..:.||::...          |.|..:...
Zfish   428 --ENGVLRLRYPPWSRYGPFLKPLDDSQHLRVVTLEERPFVIVEPADPGTGSCIRDSVPCRLPLN 490

  Fly   430 TSEKLEGNDQF----EGFGIELIDELSKKLGFSYTWRLQEDNKYG-GIDPKTGEWNGMLREIIDS 489
            .|..:||....    :||.|:::..|:|.:||:|...|..:.::| .||   |:||||:.|::..
Zfish   491 NSMVVEGIQSMKHCCKGFCIDVLKRLAKIVGFTYDLYLVTNGRHGKNID---GQWNGMVGEVVSK 552

  Fly   490 RADMGITDLTMTSERESGVDFTIPFMSLGIGILF-RKPMKEPPKLFSFMSPFSGEVWLWLGLAYM 553
            ||||.|..||:..||...|:|::||:..||.::. |......|.  :|:.|:|..||:.:.:..:
Zfish   553 RADMAIGSLTINEERSEVVEFSVPFVETGISVMVSRSNGTVSPS--AFLEPYSPAVWVMMFVMCL 615

  Fly   554 G-VSISMFVLGRLSPAEWDNPYPCIEEPTELENQFSFANCLWFSIGALLQQGSELA--PKAYSTR 615
            . |::::|:....||..::....  ...|...::|:....:|. :.||:...|...  |:..:::
Zfish   616 SVVAVTVFIFEFFSPVGYNRSLQ--SGKTAGGSKFTIGKSIWL-LWALVFNNSVPVENPRGTTSK 677

  Fly   616 AVAASWWFFTLILVSSYTANLAAFLTVESLVTPINDADDL-----SKNKGGVNYGAKIGGATFNF 675
            .:...|.||.:|.::|||||||||:..|..:..::...|.     ::....:.:|....|:|...
Zfish   678 IMVLVWAFFAVIFLASYTANLAAFMIQEEYIDTVSGLSDKKFQHPTEQYPPLRFGTVPNGSTEEN 742

  Fly   676 FKESNYPTYQRMYEFMRDNPQYMTNTNQEGV-DRVENSNY----AFLMESTTIEYIT--ERRCTL 733
            .: ||||...          |||...||.|| |.:||...    ||:.::..:.|:.  :..|.:
Zfish   743 IR-SNYPNMH----------QYMVRNNQRGVEDAIENLKTGKLDAFIYDAAVLNYMARKDEGCKV 796

  Fly   734 TQVGA--LLDEKGYGIAMRKNWPYRDTLSQAVLEMQEQGLLTKMKTKWWQEKRGGGACSDADEDS 796
            ..:|:  :....|||:|:.||..::..|..|:|::.....:..::..|.     .|.|.:...:.
Zfish   797 MTIGSGKVFATTGYGVALHKNSRWKRPLDLALLQLVGDDEIDMLERLWL-----SGICHNDKIEV 856

  Fly   797 GAVALEISNLGGVFLVMGVGSFFGIFVSLLEMVLGVKERSDENQVSFKTELLDEIRFILQCSGNT 861
            .:..|:|.|:.|||           ::.|:.|.|.:...:.|:.|.:|         :..|.|.|
Zfish   857 MSSKLDIDNMAGVF-----------YMLLVAMGLSLLVFAWEHLVYWK---------LRHCLGRT 901

  Fly   862 KAVKYPKNSSRSNAS------SKSKGSSMSVDSLPE 891
            :.:.:....||...|      ..:.|.|.|  :||:
Zfish   902 RGLDFLLAFSRGMYSCCNFEDETAPGGSQS--TLPQ 935

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Grik	NP_001262788.1	PBP1_iGluR_Kainate	37..391	CDD:107377	50/264 (19%)
		ANF_receptor	53..374	CDD:279440	45/247 (18%)
		Periplasmic_Binding_Protein_Type_2	411..781	CDD:304360	105/402 (26%)
		Lig_chan	543..816	CDD:278489	68/289 (24%)
grin2da	XP_009292354.1	PBP1_iGluR_NMDA_NR2	42..441	CDD:107373	53/274 (19%)
		PBP2_iGluR_NMDA_Nr2	452..851	CDD:270436	108/422 (26%)
		HisJ	<507..>590	CDD:223904	34/85 (40%)
		Lig_chan	605..877	CDD:278489	69/301 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591293
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840