DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Grik and grid2

DIOPT Version :9

Sequence 1:	NP_001262788.1	Gene:	Grik / 42476	FlyBaseID:	FBgn0038840	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	NP_001004123.1	Gene:	grid2 / 448841	ZFINID:	ZDB-GENE-040913-1	Length:	1009	Species:	Danio rerio

Alignment Length:	932	Identity:	245/932 - (26%)
Similarity:	425/932 - (45%)	Gaps:	113/932 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 NVGLVYENTDPDLEKIFHLAISKANEENEDLQLHGVSVSIE---PGNSFETSKKLCKMLRQNLVA 96
            ::|.:::.:....:::|.:|::..|..||.|:...::||:|   ..|.|:..::.|:::.:.::|
Zfish    28 HIGAIFDESAKKDDEVFRMAVADLNLNNEILETEKITVSVEFVDGNNPFQAVQEACELMNRGILA 92

  Fly    97 VFGPTSNLAARHAMSICDAKELPFL-DTRWDFGAQL----PTINLHPHPATL----GVALRD--- 149
            :......::|....|:.||..:|.| ..|...|...    ||....|...||    .|.|.|
Zfish    93 LVSSIGCMSAGSLQSLADAMHIPHLFIQRAPAGTPRSSCPPTTRAQPDDYTLFVRPPVYLNDVIF 157

  Fly   150 -MVVALGWESFTIIYESGEYLPTVRELLQMYGTAGPTVTVRRYELDLN---------------GN 198
             :|:...|:.|.|.|::...:..:...|......|..|::::.|.::|               ..
Zfish   158 QVVMEYTWQKFIIFYDTDYDIRGIENFLDQTSQQGMDVSLQKVESNINMMITGMFRTMRVEELHR 222

  Fly   199 YRNVLRRIRNADDFSFVVVGSMATLPEFFKQAQQVGLVTSDYRYIIGNLDWHTMDL-EPYQHAGT 262
            ||:.|||.        |:..|.||...|..:..:..||..|.::||.|.:...||: |....:..
Zfish   223 YRDTLRRA--------VLFMSPATAKAFITEVVETNLVAFDCQWIIINEEISDMDVQELVMKSIG 279

  Fly   263 NITGLRLVSPDSEQVQE--------VAKALYESEEPFQNVSCPLTNSMALVYDGVQLLAETY-KH 318
            .:|.:|...|..:...:        :..:|.:.::|...: ..:||  ..:||.|.|||.|: :.
Zfish   280 RLTLVRQTFPLPQNTSQRCVRNNHRINTSLCDPKDPKAQM-LEITN--RYIYDTVLLLANTFHRK 341

  Fly   319 VNFRP----VALSC--NDDSAWDKGYTLVNYMKSLTLNGLTGPIRFDYEGLRTDFKLEVI----- 372
            :..|.    .:|||  .....|..|.:::..:|...::|||..:.|:..|...:...|::
Zfish   342 LEDRKWHSMASLSCIRKGSKPWQGGKSMLETVKKGGVSGLTSLLEFNDNGSNPNIHFEILGTNYG 406

  Fly   373 ELAVSGMQKIGQWSGEDGFQENRPAPAHSLEPDMRSLVNKSFVVITAISEPYGMLKETSEKLEGN 437
            |....|:.::..|....|.  |.......||.:||.:|.:   |:|.:.||:.|:   ||.:.|.
Zfish   407 EDRGRGVSRLATWDPIHGL--NGTLTDRKLENNMRGVVLR---VVTVLEEPFVMV---SENVLGK 463

  Fly   438 -DQFEGFGIELIDELSKKLGFSYTWRLQEDNKYGGIDPKTGEWNGMLREIIDSRADMGITDLTMT 501
             .:::||.|:::|.|:..|||.|...:..|:|||. ....|.|||::.|::..|||:|::.||:|
Zfish   464 PKKYQGFSIDVLDALANYLGFKYEIYVAPDHKYGS-QQADGTWNGLIGELVFKRADVGLSALTIT 527

  Fly   502 SERESGVDFTIPFMSLGIGILFRKPMKEPPKLFSFMSPFSGEVWLWLGLAYMGVSISMFVLGRLS 566
            .||||.||||..:|...:|:|.|| .:....:|:.::||...:|..:....:.|...:::|
Zfish   528 PERESVVDFTTRYMDYSVGVLLRK-AERTVDMFACLAPFDLSLWACIAGTVLLVGTLVYLL---- 587

  Fly   567 PAEWDNPYPCIEEPTELENQFSFANCLWFSIGALLQQGSELAPKAYSTRAVAASWWFFTLILVSS 631
              .|.|| |.:  |....:..:..|.:||..|:.:|||.|:.....:||.:...||.|.||::||
Zfish   588 --NWLNP-PRL--PMGSVSSTTLYNSMWFVYGSFVQQGGEVPYTTLATRMMMGVWWLFALIVISS 647

  Fly   632 YTANLAAFLTVESLVTPINDADDLSKNKGGVNYGAKIGGATFNFFKESNY------PTYQRMYEF 690
            ||||||||||:..:...|....||:| :..:.||..:..|.::..:....      |.|.:|:..
Zfish   648 YTANLAAFLTISRIENSIQSLQDLAK-QTDLPYGTVLDSAVYDQVRSKGMNPFERDPMYSQMWRM 711

  Fly   691 MRDNPQYMTNT--NQEGVDRVENSNYAFLMESTTIEY--ITERRCTLTQVGALLDEKGYGIAMRK 751
            :........|.  ::||:.:|:...:||:.::..:||  |.:..|:|..|...:.::|||:||:.
Zfish   712 INRTGGAENNVEESKEGIRKVKYGRFAFVWDAAVLEYVAINDEDCSLYTVSNNVADRGYGMAMQH 776

  Fly   752 NWPYRDTLSQAVLEMQEQGLLTKMKTKWWQEKRGGGACSDADEDSGAVALEISNLGGVFLVMGVG 816
            ..||||..||.:||:|:.|.:..:|.|||.........|.........||:|.:..|||.|:..|
Zfish   777 GSPYRDIFSQRILELQQNGDMDILKLKWWPRDSPCDLYSPVGTRKSGSALDIHSFAGVFFVLAAG 841

  Fly   817 SFFGIFVSLLE----MVLGVKERSDENQVSFKTELLDEIRFILQCSGNTKAVKYPKNSSRSNASS 877
            ......::.:|    ...|.:..|.|:......|.|.. |....|:              .:.|.
Zfish   842 VVLSCLIATVETWWTRRKGSRVPSKEDDKEIDLEHLHH-RVNSLCT--------------EDESP 891

  Fly   878 KSKGSSMSVDSLPEDTSEADAS 899
            ..:.|:.|:|..|.|.....|:
Zfish   892 HKQFSTSSIDLTPLDMDSLPAA 913

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Grik	NP_001262788.1	PBP1_iGluR_Kainate	37..391	CDD:107377	89/405 (22%)
		ANF_receptor	53..374	CDD:279440	84/372 (23%)
		Periplasmic_Binding_Protein_Type_2	411..781	CDD:304360	124/380 (33%)
		Lig_chan	543..816	CDD:278489	84/282 (30%)
grid2	NP_001004123.1	PBP1_iGluR_delta_2	28..427	CDD:107386	90/411 (22%)
		ANF_receptor	42..404	CDD:279440	85/372 (23%)
		PBP2_iGluR_delta_2	440..806	CDD:270449	125/383 (33%)
		Lig_chan	568..841	CDD:278489	84/282 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	989..1009
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591284
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.840