DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Grik and GluRIID

DIOPT Version :9

Sequence 1:	NP_001262788.1	Gene:	Grik / 42476	FlyBaseID:	FBgn0038840	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	NP_651982.1	Gene:	GluRIID / 44483	FlyBaseID:	FBgn0028422	Length:	902	Species:	Drosophila melanogaster

Alignment Length:	880	Identity:	413/880 - (46%)
Similarity:	582/880 - (66%)	Gaps:	17/880 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 AFPGCRGERTNVGLVYENTDPDLEKIFHLAISKANEENEDLQLHGVSVSIEPGNSFETSKKLCKM 89
            |:....|:...:||:.::....:.:.|..|||..|.| ..:.|.|.:..:..|||.:...:||::
  Fly    25 AYEASSGQSIRLGLITDDATDRIRQTFEHAISVVNNE-LGVPLVGETEQVAYGNSVQAFAQLCRL 88

  Fly    90 LRQNLVAVFGPTSNLAARHAMSICDAKELPFLDTRWDFGAQLPTINLHPHPATLGVALRDMVVAL 154
            ::..:.|||||.:...|.|.::.||:|::||:.....:|:.....||||.|..:..||.|:|...
  Fly    89 MQSGVGAVFGPAARHTASHLLNACDSKDIPFIYPHLSWGSNPDGFNLHPSPEDIANALYDIVNQF 153

  Fly   155 GWESFTIIYESGEYLPTVRELLQMYGTAGPTVTVRRYELDLNGNYRNVLRRIRNADDFSFVVVGS 219
            .|..|...|||.|||..:..|:..||..||.:.|.||:|:|||||::||||||.::|...|||||
  Fly   154 EWSRFIFCYESAEYLKILDHLMTRYGIKGPVIKVMRYDLNLNGNYKSVLRRIRKSEDSRIVVVGS 218

  Fly   220 MATLPEFFKQAQQVGLVTSDYRYIIGNLDWHTMDLEPYQHAGTNITGLRLVSPDSEQVQEVAKAL 284
            ...:.|..:||||||::..||.||||||:.||.|||.|:::..||||:|:.|||.|:|:::.:.|
  Fly   219 TTGVAELLRQAQQVGIMNEDYTYIIGNLNLHTFDLEEYKYSEANITGIRMFSPDQEEVRDLMEKL 283

  Fly   285 YE---SEEPFQNVSCPLTNSMALVYDGVQLLAETYKHVNFRPVALSCND--DSAWDKGYTLVNYM 344
            ::   ..||..:.|..:|..|||.||.|:::|||.||:.::|..|:|::  |:....|.|..|||
  Fly   284 HQELGESEPVNSGSTFITMEMALTYDAVRVIAETTKHLPYQPQMLNCSERHDNVQPDGSTFRNYM 348

  Fly   345 KSLTLNGLTGPIRFDYEG-LRTDFKLEVIELAVSGMQKIGQWSGEDGFQENRPAPAHSL-EPDMR 407
            :||.:...|...|..:|| :|..|..:||||..||:.|:|.|.....|:..||..|.:. :.|..
  Fly   349 RSLEIKEKTITGRIYFEGNVRKGFTFDVIELQTSGLVKVGTWEEGKDFEFQRPPQAVNFNDIDDG 413

  Fly   408 SLVNKSFVVITAI-SEPYGMLKETSEKLEGNDQFEGFGIELIDELSKKLGFSYTWRLQEDNKYGG 471
            |||||:|:|:.:: ::||..|.|:.:.|.||:||:|:|::||.||:.||||::|:| ...|.||.
  Fly   414 SLVNKTFIVLISVATKPYASLVESIDTLIGNNQFQGYGVDLIKELADKLGFNFTFR-DGGNDYGS 477

  Fly   472 IDPKTGEWNGMLREIIDSRADMGITDLTMTSERESGVDFTIPFMSLGIGILFRKPMKEPPKLFSF 536
            .:..|...:|||:||::.|||:.|||||:|||||..:||:||||:|||.||:.||.|.||.||||
  Fly   478 FNKTTNSTSGMLKEIVEGRADLAITDLTITSEREEVIDFSIPFMNLGIAILYVKPQKAPPALFSF 542

  Fly   537 MSPFSGEVWLWLGLAYMGVSISMFVLGRLSPAEWDNPYPCIEEPTELENQFSFANCLWFSIGALL 601
            |.|||.||||:||:||:|||:..|::|||||.||||||||||||.||||||:..|.|||:.||||
  Fly   543 MDPFSSEVWLYLGIAYLGVSLCFFIIGRLSPIEWDNPYPCIEEPEELENQFTINNSLWFTTGALL 607

  Fly   602 QQGSELAPKAYSTRAVAASWWFFTLILVSSYTANLAAFLTVESLVTPINDADDLSKNKGGVNYGA 666
            |||||:||||.|||.::|.|||||||:|||||||||||||:|:..:|||...||:.||..|.|||
  Fly   608 QQGSEIAPKALSTRTISAIWWFFTLIMVSSYTANLAAFLTIENPTSPINSVKDLADNKDDVQYGA 672

  Fly   667 KIGGATFNFFKESNYPTYQRMYEFMRDNPQYMTNTNQEGVDRVEN-SNYAFLMESTTIEYITERR 730
            |..|:|.|||..|..|.|.:|.|::..:|:.:...||:|||:|:: :.||||||||:||:.|.|.
  Fly   673 KRTGSTRNFFSTSEEPIYIKMNEYLNAHPEMLMENNQQGVDKVKSGTKYAFLMESTSIEFNTVRE 737

  Fly   731 CTLTQVGALLDEKGYGIAMRKNWPYRDTLSQAVLEMQEQGLLTKMKTKWWQEKRGGGACSDADED 795
            |.||:||..||||||||||.|||||||..::|:||:||||:|.::|.|||.|. |.|.||...:|
  Fly   738 CNLTKVGDPLDEKGYGIAMVKNWPYRDKFNKALLELQEQGVLARLKNKWWNEV-GAGVCSAKSDD 801

  Fly   796 SGAVALEISNLGGVFLVMGVGSFFGIFVSLLEMVLGVKERSDENQVSFKTELLDEIRFILQCSGN 860
            .|...|.:.||.|:::|:.:||...|.:|:|.....|.:::...:|.|...|.:|.|.:::.|.|
  Fly   802 DGPSELGVDNLSGIYVVLVIGSIISIIISILCWCYFVYKKAKNYEVPFCDALAEEFRIVIRFSEN 866

  Fly   861 TKAVKYPKNSSRSNASSKSKGSSMSVDSLPEDTSE 895
            .:.:|     |..:..|:|:.||.|::||..|:.|
  Fly   867 ERPLK-----SAQSIYSRSRNSSQSIESLKTDSEE 896

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Grik	NP_001262788.1	PBP1_iGluR_Kainate	37..391	CDD:107377	144/359 (40%)
		ANF_receptor	53..374	CDD:279440	134/326 (41%)
		Periplasmic_Binding_Protein_Type_2	411..781	CDD:304360	222/371 (60%)
		Lig_chan	543..816	CDD:278489	164/273 (60%)
GluRIID	NP_651982.1	PBP1_iGluR_Kainate	35..397	CDD:107377	144/362 (40%)
		ANF_receptor	46..380	CDD:279440	136/334 (41%)
		PBP2_iGluR_Kainate	417..788	CDD:270432	222/371 (60%)
		Lig_chan	549..819	CDD:278489	163/270 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45447137
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	137	1.000	Inparanoid score	I1813
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D17567at33392
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm1027
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	P	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	9	8.900