DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Grik and CG11155

DIOPT Version :9

Sequence 1:	NP_001262788.1	Gene:	Grik / 42476	FlyBaseID:	FBgn0038840	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	NP_651941.2	Gene:	CG11155 / 43822	FlyBaseID:	FBgn0039927	Length:	910	Species:	Drosophila melanogaster

Alignment Length:	888	Identity:	331/888 - (37%)
Similarity:	501/888 - (56%)	Gaps:	53/888 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 FILTSLLL---AFPGCRGERTNVGLVY--ENTDPDLEKIFHLAISKANEENEDLQLHGVSVSIE- 75
            :|:.|:|:   |.|..    ..||.::  :..:..:|..|..||.:.|:|...|....:...||
  Fly    27 YIILSILVISNALPPV----IRVGAIFTEDERESSIESAFKYAIYRINKEKTLLPNTQLVYDIEY 87

  Fly    76 --PGNSFETSKKLCKMLRQNLVAVFGPTSNLAARHAMSICDAKELPFLDTRWD--FGAQLPTINL 136
              ..:||.|:||:|..|...:.|:||||..|.|.|..|||:|.::|.::.|.|  :.::..:|||
  Fly    88 VPRDDSFRTTKKVCSQLEAGVQAIFGPTDALLASHVQSICEAYDIPHIEGRIDLEYNSKEFSINL 152

  Fly   137 HPHPATLGVALRDMVVALGWESFTIIYESGEYL-----PTVRELLQMYGTAGPTVTVRRYELDLN 196
            :|....|.:|.||::|.|.|....||||....|     .:.....:||        :|:...|
  Fly   153 YPSHTLLTLAYRDIMVYLNWTKVAIIYEEDYGLFNLMHSSTETKAEMY--------IRQASPD-- 207

  Fly   197 GNYRNVLRRIRNADDFSFVVVGSMATLPEFFKQAQQVGLVTSDYRYIIGNLDWHTMDLEPYQHAG 261
             :||.|||.||..:.:..:|..:.:.:..||:...|:.:....|.|:....|..|.|||.:::..
  Fly   208 -SYRQVLRAIRQKEIYKIIVDTNPSHIKSFFRSILQLQMNDHRYHYMFTTFDLETYDLEDFRYNS 271

  Fly   262 TNITGLRLVSPDSEQVQEVAKALYESEE---PFQNVSCPLTNSMALVYDGVQLLAETY------K 317
            .|||..|||..||::..||...:.:.:.   ...|.|..:....||::|.|...|...      .
  Fly   272 VNITAFRLVDVDSKRYLEVINQMQKLQHNGLDTINGSPYIQTESALMFDSVYAFANGLHFLNLDN 336

  Fly   318 HVNFRPVALSCNDDSAWDKGYTLVNYMKSLTLNGLTGPIRFDYEGLRTDFKLEVIELAVSGMQKI 382
            |.||....|||..|..|:.|.:|.|.:.:...:||||.::| .||.|..|||::::|....:||:
  Fly   337 HQNFYIKNLSCTSDQTWNDGISLYNQINAAITDGLTGTVQF-VEGRRNIFKLDILKLKQEKIQKV 400

  Fly   383 GQWSGEDGFQENRPAPAHSLEPDMRSLVNKSFVVITAISEPYGMLKETSEKLEGNDQFEGFGIEL 447
            |.|..:||...:.|...:.     .::.|.:.||:|....||.|:|| .:.|.||.:||||.|:|
  Fly   401 GYWHPDDGVNISDPTAFYD-----SNIANITLVVMTREERPYVMVKE-DKNLTGNLRFEGFCIDL 459

  Fly   448 IDELSKKLGFSYTWRLQEDNKYGGIDPKTGEWNGMLREIIDSRADMGITDLTMTSERESGVDFTI 512
            :..::.::||.|...|..||.||...|:|..|||:::|:::.|||:.:..:|:...|||.:|||.
  Fly   460 LKAIATQVGFQYKIELVPDNMYGVYIPETNSWNGIVQELMERRADLAVASMTINYARESVIDFTK 524

  Fly   513 PFMSLGIGILFRKPMKEPPKLFSFMSPFSGEVWLWLGLAYMGVSISMFVLGRLSPAEWDNPYPCI 577
            |||:|||||||:.|..:|.:|||||:|.:.|:||::..||:.||.::||:.|.||.||.||:||.
  Fly   525 PFMNLGIGILFKVPTSQPTRLFSFMNPLAIEIWLYVLAAYILVSFALFVMARFSPYEWKNPHPCY 589

  Fly   578 EEPTELENQFSFANCLWFSIGALLQQGSELAPKAYSTRAVAASWWFFTLILVSSYTANLAAFLTV 642
            :|...:|||||.:|..||..|..|:|||.|.|||.|||.|...|:||.||::|||||||||||||
  Fly   590 KETDIVENQFSISNSFWFITGTFLRQGSGLNPKATSTRIVGGCWFFFCLIIISSYTANLAAFLTV 654

  Fly   643 ESLVTPINDADDLSKNKGGVNYGAKIGGATFNFFKESNYPTYQRMYEFMRD-NPQYMTNTNQEGV 706
            |.:::||..|.||:: :..::||...||:|..||::|....||:|:.:|.: .......|.::|:
  Fly   655 ERMISPIESASDLAE-QTEISYGTLEGGSTMTFFRDSKIGIYQKMWRYMENRKTAVFVKTYEDGI 718

  Fly   707 DRVENSNYAFLMESTTIEYITERRCTLTQVGALLDEKGYGIAMRKNWPYRDTLSQAVLEMQEQGL 771
            .||...:||||||||.::|..:|.|.|||:|.|||.||||||..|..|:||.:|.|:||:||:|:
  Fly   719 KRVMEGSYAFLMESTMLDYAVQRDCNLTQIGGLLDSKGYGIATPKGSPWRDKISLAILELQEKGI 783

  Fly   772 LTKMKTKWWQEKRGGGACS--DADEDSGAVALEISNLGGVFLVMGVGSFFGIFVSLLEMVLGVKE 834
            :..:..|||  |..|..|:  |..::|.|.||.:.|:||||:|:..|....:.|::.|.....::
  Fly   784 IQILYDKWW--KNTGDVCNRDDKSKESKANALGVENIGGVFVVLLCGLALAVVVAIFEFCWNSRK 846

  Fly   835 RSDENQVSFKTELLDEIRFILQCSGNTKAVKYPKNSSRSNASS 877
            ..:....|..:|:.:|:||.:.|.| :|:...|:..|..|.||
  Fly   847 NLNTENQSLCSEMAEELRFAMHCHG-SKSRHRPRKRSCLNCSS 888

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Grik	NP_001262788.1	PBP1_iGluR_Kainate	37..391	CDD:107377	115/374 (31%)
		ANF_receptor	53..374	CDD:279440	106/339 (31%)
		Periplasmic_Binding_Protein_Type_2	411..781	CDD:304360	177/370 (48%)
		Lig_chan	543..816	CDD:278489	132/275 (48%)
CG11155	NP_651941.2	PBP1_iGluR_Kainate	44..410	CDD:107377	117/377 (31%)
		ANF_receptor	61..393	CDD:279440	107/343 (31%)
		PBP2_iGluR_Kainate	424..793	CDD:270432	178/372 (48%)
		Lig_chan	555..829	CDD:278489	132/276 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462873
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	495	1.000	Inparanoid score	I765
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D60688at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm1027
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	P	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	9	8.900