DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Grik and Ekar

DIOPT Version :9

Sequence 1:	NP_001262788.1	Gene:	Grik / 42476	FlyBaseID:	FBgn0038840	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	NP_001036250.1	Gene:	Ekar / 43806	FlyBaseID:	FBgn0039916	Length:	899	Species:	Drosophila melanogaster

Alignment Length:	913	Identity:	309/913 - (33%)
Similarity:	499/913 - (54%)	Gaps:	87/913 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 GFILTSLL---LAFPGCRGERTNVGLVYENTDPDL---EKIFHLAISKANEENEDLQLHGVSVSI 74
            ||:|...|   |..|    ....:|.::.| .|.:   |..|..||.:.|.:...|....|...:
  Fly     6 GFLLFQFLSYGLGVP----PLVRIGAIFSN-QPGMYNSELAFRYAIHRLNMDKSLLPETTVDYYV 65

  Fly    75 EPGN---SFETSKKLCKMLRQNLVAVFGPTSNLAARHAMSICDAKELPFLD-TRWDFGAQLPTIN 135
            |..|   ||||.:|:||::|..:.|||.||.::.|.|..|||||.::|.:. :..||     :||
  Fly    66 EYVNRFDSFETVQKVCKLIRVGVQAVFSPTDSVLATHINSICDALDIPNIGRSAHDF-----SIN 125

  Fly   136 LHPHPATLGVALRDMVVALGWESFTIIYESGEYLPTVRELLQMYGTAGPTVTVRRYELDLNGNYR 200
            ::|....:..|..|::..|.|..|.|::|....:..:.:|.:.:   ...|.:|:...|   :|.
  Fly   126 VYPSKQLVNYAFNDVIQYLNWTRFGILHEKENGIINLHQLSRSF---HGEVHMRQVSRD---SYV 184

  Fly   201 NVLRRIRNADDFSFVVVGSMATLPEFFKQAQQVGLVTSDYRYIIGNLDWHTMDLEPYQHAGTNIT 265
            :.|...:..:..:.::..:...:....|...|..:....|.|:..:.|..|.|||.:::...|||
  Fly   185 SALNEFKGKEIHNIIIDTNSNGISILLKNILQQQMNEYKYHYLFTSFDLETYDLEDFKYNFVNIT 249

  Fly   266 GLRLVSPDSEQVQEVAK--ALYES---EEPFQNV----SCPLTNSMALVYD-------GVQLLAE 314
            ..|||......|:::.|  .||..   ::|:.|:    |..|.:..||::|       |:|.|.:
  Fly   250 SFRLVDTADVGVKQILKDIGLYSHHIFKKPYLNLHIKKSTILESEPALMFDSVYVFAIGLQTLEQ 314

  Fly   315 TYKHVNFRPVALSCNDDSAWDKGYTLVNYMKSLTLNGLTGPIRFDYEGLRTDFKLEVIELAVSGM 379
            ::   :...:.:||.::::||.|.:|:||:.::...||||||:|. :|.|..|||::|:|....:
  Fly   315 SH---SLTLLNISCEEENSWDGGLSLINYLNAVEWKGLTGPIQFK-DGQRVQFKLDLIKLKQHSI 375

  Fly   380 QKIGQWSGEDGFQENRPAPAHSLEPDMRSLVNKSFVVITAISEPYGMLKETSEKLEGNDQFEGFG 444
            .|:|:|:.........|    |:..|..|: |.:.||||.:..||.|: ...:...||::|.||.
  Fly   376 VKVGEWTPHGHLNITEP----SMFFDAGSM-NVTLVVITILETPYVMM-HYGKNFTGNERFYGFC 434

  Fly   445 IELIDELSKKLGFSYTWRLQEDNKYGGIDPKTGEWNGMLREIIDSRADMGITDLTMTSERESGVD 509
            :::::.:|:::||.|...|..|.|||..||:|||||||:.:::..:||:.:..:|:|..|||.:|
  Fly   435 VDILETISREVGFDYILDLVPDRKYGAKDPETGEWNGMVAQLMKYKADLAVGSMTITYARESVID 499

  Fly   510 FTIPFMSLGIGILFRKPMKEPPKLFSFMSPFSGEVWLWLGLAYMGVSISMFVLGRLSPAEWDNPY 574
            ||.|||:|||.|||:.|..||.:|||||:|.:.|:|:::.:||..||:.::::|:|||.||....
  Fly   500 FTKPFMNLGISILFKVPTSEPTRLFSFMNPLAIEIWIYVLIAYFLVSLCIYIVGKLSPIEWKCIN 564

  Fly   575 PCIEEPTELENQFSFANCLWFSIGALLQQGSELAPKAYSTRAVAASWWFFTLILVSSYTANLAAF 639
            .|..|...:.||||..:..||:||..:||..::.|:|.|||.::::|.||:||:|:|||||||||
  Fly   565 ACDLENISIGNQFSLTDSFWFTIGTFMQQSPDIYPRAMSTRIISSTWGFFSLIIVASYTANLAAF 629

  Fly   640 LTVESLVTPINDADDLSKNKGGVNYGAKIGGATFNFFKESNYPTYQRMYEFMRDN--PQYMTNTN 702
            ||.|.::.||.:|:||: ::..::||....|:|..||::|...||::::..| ||  |...|.|.
  Fly   630 LTTERMINPIENAEDLA-SQTEISYGTLDSGSTMTFFRDSVIETYKKIWRSM-DNKKPSAFTTTY 692

  Fly   703 QEGVDRVENSNYAFLMESTTIEYITERRCTLTQVGALLDEKGYGIAMRKNWPYRDTLSQAVLEMQ 767
            ::|:.||...|||||||||.::||.:|.|.|||:|.|||.||||||..|..|:||.:|.|:||:|
  Fly   693 EDGIKRVNQGNYAFLMESTMLDYIVQRDCNLTQIGGLLDTKGYGIATPKGSPWRDKISLAILELQ 757

  Fly   768 EQGLLTKMKTKWWQEKRGGGACS--DADEDSGAVALEISNLGGVFLVMGVGSFFGIFVSLLEMVL 830
            |:|.:..:..|||  |.....|:  :..:.|.|.:|.:.::||||:|:..|......|:..|...
  Fly   758 ERGDIQMLYDKWW--KNTDETCTRKNTSKQSKANSLGLESIGGVFVVLIAGIIVAAVVAFFEFWY 820

  Fly   831 ----------------------GVKERSDENQV----SFKTELLDEIRFILQCSGNTKAVKYPKN 869
                                  |:.| |:.|..    ||..|:.:|:|:...|....|.....:.
  Fly   821 NFRYNYEATPSQSVVNNKYNQDGILE-SERNYTPPDRSFWIEIAEELRYASWCMNKQKRPALTRT 884

  Fly   870 SSR 872
            .|:
  Fly   885 CSK 887

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Grik	NP_001262788.1	PBP1_iGluR_Kainate	37..391	CDD:107377	105/376 (28%)
		ANF_receptor	53..374	CDD:279440	96/340 (28%)
		Periplasmic_Binding_Protein_Type_2	411..781	CDD:304360	168/371 (45%)
		Lig_chan	543..816	CDD:278489	120/276 (43%)
Ekar	NP_001036250.1	PBP1_iGluR_Kainate	24..388	CDD:107377	105/379 (28%)
		ANF_receptor	39..371	CDD:279440	98/346 (28%)
		PBP2_iGluR_Kainate	402..771	CDD:270432	169/373 (45%)
		Lig_chan	533..807	CDD:278489	120/277 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462874
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	495	1.000	Inparanoid score	I765
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D60688at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm1027
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	P	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	9	8.900