DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Grik and KaiR1D

DIOPT Version :9

Sequence 1:	NP_001262788.1	Gene:	Grik / 42476	FlyBaseID:	FBgn0038840	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	NP_650925.1	Gene:	KaiR1D / 42473	FlyBaseID:	FBgn0038837	Length:	853	Species:	Drosophila melanogaster

Alignment Length:	852	Identity:	366/852 - (42%)
Similarity:	539/852 - (63%)	Gaps:	45/852 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 LGFILTSLLLAFPGCRGERT-----NVGLVYENTDPDLEKIFHLAISKANEENEDLQLHGVSVSI 74
            |..:|..|:|   .||..::     .:|.::...|...|..|..|:.:.|.:...|....:...|
  Fly     9 LPLLLLQLIL---NCRKAQSLPDIIKIGGLFHPADDHQELAFRQAVDRINADRSILPRSKLVAQI 70

  Fly    75 E---PGNSFETSKKLCKMLRQNLVAVFGPTSNLAARHAMSICDAKELPFLDTRWDFGAQLPT--I 134
            |   |.:||...|::|.:|...:.|:|||.|:..|.|..||||..|:|.|:.|||:..:..:  :
  Fly    71 ERISPFDSFHAGKRVCGLLNIGVAAIFGPQSSHTASHVQSICDNMEIPHLENRWDYRLRRESCLV 135

  Fly   135 NLHPHPATLGVALRDMVVALGWESFTIIYESGEYLPTVRELLQMYGTAGPTVTVRRYELDLNGNY 199
            ||:|||.||..|..|:|...||::||||||:.:.:..::|||:.:|.....:|||  :|..:|:|
  Fly   136 NLYPHPNTLSKAYVDIVRHWGWKTFTIIYENNDGIVRLQELLKAHGMTPFPITVR--QLSDSGDY 198

  Fly   200 RNVLRRIRNADDFSFVVVGSMATLPEFFKQAQQVGLVTSDYRYIIGNLDWHTMDLEPYQHAGTNI 264
            |.:|::|:|:.:...|:..|...:.|..|||||:|:::..:.|::.:||.||::|:.:::.||||
  Fly   199 RPLLKQIKNSAEAHIVLDCSTERIHEVLKQAQQIGMMSDYHSYLVTSLDLHTVNLDEFRYGGTNI 263

  Fly   265 TGLRLVSPDSEQVQEVAKALYESEEPFQNVSCPLT---NSMALVYDGVQLLA------ETYKHVN 320
            ||.||:  :.:.|.:|.:. :..:|.....|..||   :..||:||.|.|.|      :|.:.::
  Fly   264 TGFRLI--NEKIVSDVVRQ-WSIDEKGLLRSANLTTVRSETALMYDAVHLFAKALHDLDTSQQID 325

  Fly   321 FRPVALSCNDDSAWDKGYTLVNYMKSLTLNGLTGPIRFDYEGLRTDFKLEVIELAVSGMQKIGQW 385
            ..|:  ||:..|.|..|::|:||||.:.:.|||..|:||::|.||||.|:::||..:|::|||.|
  Fly   326 IHPI--SCDGQSTWQHGFSLINYMKIVEMKGLTNVIKFDHQGFRTDFMLDIVELTPAGIRKIGTW 388

  Fly   386 SG--EDGFQENRPAPAHSLEPDMRSLVNKSFVVITAISEPYGMLKETSEKLEGNDQFEGFGIELI 448
            :.  .||....|.......|.: .:|.||:.||.|.:|.||.|.||::..|.|||||||:.::||
  Fly   389 NSTLPDGINFTRTFSQKQQEIE-ANLKNKTLVVTTILSNPYCMRKESAIPLSGNDQFEGYAVDLI 452

  Fly   449 DELSKKLGFSYTWRLQEDNKYGGIDPKTGEWNGMLREIIDSRADMGITDLTMTSERESGVDFTIP 513
            .|:||.|||:|..:|..|..||.::..|||||||:||:::.|||:.|.|||:|.|||..||||.|
  Fly   453 HEISKSLGFNYKIQLVPDGSYGSLNKLTGEWNGMIRELLEQRADLAIADLTITFEREQAVDFTTP 517

  Fly   514 FMSLGIGILFRKPMKEPPKLFSFMSPFSGEVWLWLGLAYMGVSISMFVLGRLSPAEWDNPYPCIE 578
            ||:||:.||:|||:|:||.||||:||.|.:||:::..||:|||:.:|:|.:.:|.||  |.....
  Fly   518 FMNLGVSILYRKPIKQPPNLFSFLSPLSLDVWIYMATAYLGVSVLLFILAKFTPYEW--PAYTDA 580

  Fly   579 EPTELENQFSFANCLWFSIGALLQQGSELAPKAYSTRAVAASWWFFTLILVSSYTANLAAFLTVE 643
            ...::|:||:..||:||:||:|:|||.:..|||.|||.||..|||||||::||||||||||||||
  Fly   581 HGEKVESQFTLLNCMWFAIGSLMQQGCDFLPKALSTRMVAGIWWFFTLIMISSYTANLAAFLTVE 645

  Fly   644 SLVTPINDADDLSKNKGGVNYGAKIGGATFNFFKESNYPTYQRMYEFMRD-NPQYMTNTNQEGVD 707
            .:.:||..|:||:| :..:.|||..||:|..||::|...|||||:.||.. .|...|.:|.|||:
  Fly   646 RMDSPIESAEDLAK-QTRIKYGALKGGSTAAFFRDSKISTYQRMWSFMESARPSVFTASNGEGVE 709

  Fly   708 RVE--NSNYAFLMESTTIEYITERRCTLTQVGALLDEKGYGIAMRKNWPYRDTLSQAVLEMQEQG 770
            ||.  ..:||||||||:|||:|||.|.|||||.:||.|.||||...|.|||..::..:|::||:|
  Fly   710 RVAKGKGSYAFLMESTSIEYVTERNCELTQVGGMLDTKSYGIATPPNSPYRTAINSVILKLQEEG 774

  Fly   771 LLTKMKTKWWQEKRGGGAC--SDADEDSGAVALEISNLGGVFLVMGVGSFFGIFVSLLEMV---- 829
            .|..:|||||:||||||.|  ..:...|.|..|.::|:||||:|:..|......:::.|.|
  Fly   775 KLHILKTKWWKEKRGGGKCRVETSKSSSAANELGLANVGGVFVVLMGGMGVACVIAVCEFVWKSR 839

  Fly   830 -LGVKER 835
             :.|:||
  Fly   840 KVAVEER 846

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Grik	NP_001262788.1	PBP1_iGluR_Kainate	37..391	CDD:107377	132/369 (36%)
		ANF_receptor	53..374	CDD:279440	120/334 (36%)
		Periplasmic_Binding_Protein_Type_2	411..781	CDD:304360	201/372 (54%)
		Lig_chan	543..816	CDD:278489	142/277 (51%)
KaiR1D	NP_650925.1	PBP1_iGluR_Kainate	31..397	CDD:107377	133/372 (36%)
		ANF_receptor	42..378	CDD:279440	123/342 (36%)
		Periplasmic_Binding_Protein_Type_2	415..785	CDD:304360	201/372 (54%)
		Lig_chan	547..823	CDD:278489	142/278 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	495	1.000	Inparanoid score	I765
Isobase	1	0.950	-	0	Normalized mean entropy	S3952
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D17567at33392
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm1027
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	P	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	9	8.920