DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Grik and Ir84a

DIOPT Version :9

Sequence 1:	NP_001262788.1	Gene:	Grik / 42476	FlyBaseID:	FBgn0038840	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	NP_649720.2	Gene:	Ir84a / 40891	FlyBaseID:	FBgn0037501	Length:	644	Species:	Drosophila melanogaster

Alignment Length:	576	Identity:	125/576 - (21%)
Similarity:	215/576 - (37%)	Gaps:	145/576 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   329 NDDSAWDKGYTLVNYMKSLTLNGLTGPIRFDYE-GLRTDFKLEVIELAVSG-------------- 378
            |:..||   :.|.:..:||.:..|...:...|. |:..|     |.:|:.|
  Fly   125 NNSLAW---FILGSGRESLPVEQLIDQLLSGYRMGIDAD-----ITVALRGPDNASMLFYDVYRI 181

  Fly   379 ---------MQKIGQWSGEDGFQE----------NRPAPAHSLEPDMRSLVNKSFVVITAISE-P 423
                     ::|.|.|:...|:|:          .|           |:.:|.:.:..|.::| |
  Fly   182 SRQANTPLIIEKKGLWTHSGGYQKFGNFKNTWVIRR-----------RNFLNVTLIGSTVLTEKP 235

  Fly   424 YGMLKETSEKLEGNDQFEGFG------------IELIDELSKKLGFSYTWRLQEDNKYGGIDPKT 476
            .|.  ...|.|..:.|.:...            :|.:..||..:..:..|....||
  Fly   236 PGF--GDMEYLADDKQLQQLDPMQRKTYQLFQLVERMFNLSLAISLTDKWGELLDN--------- 289

  Fly   477 GEWNGMLREIIDSRADMGITDLTMTSERESGVDFTIPFMSLGIGILFRKPMKEPPKLFSFMSPFS 541
            |.|:|::.::....||..:..:....:|:..|.::....:..|..|||.|.:...|.. |..|.|
  Fly   290 GSWSGVMGQVTSREADFAVCPIRFVLDRQPYVQYSAVLHTQNIHFLFRHPRRSHIKNI-FFEPLS 353

  Fly   542 GEVWLWLGLAYM-GVSISMFVLGRLSPAEWDNPYPCIEEPTELENQFSFANCLWFS-IGALLQQG 604
            .:|| |..||.: |.:|.:....||.           ...:.:||:|||   :||: :...||||
  Fly   354 NQVW-WCVLALVTGSTILLLFHVRLE-----------RMLSNMENRFSF---VWFTMLETYLQQG 403

  Fly   605 --SELAPKAYSTRAVAASWWFFTLILVSSYTANLAAFLTVESLVTPIN-----DADDLSKNKGGV 662
              :|:. :.:|||.:.:....|:.:|:..|.|.:...|..||..:.:|     |: :|:.....:
  Fly   404 PANEIF-RLFSTRLLISLSCIFSFMLMQFYGAFIVGSLLSESARSIVNLQALYDS-NLAIGMENI 466

  Fly   663 NYGAKIGGATFNFFKESNYPTYQRMYEFMRD--------NPQYMTNTNQEGVDRVENSNYAF--- 716
            :|...|      |...||        :.:||        :.::...:.|:|.:|:....:||
  Fly   467 SYNFPI------FTNTSN--------QLVRDVYVKKICKSGEHNIMSLQQGAERIIQGRFAFHTA 517

  Fly   717 -------LMESTTIEYITERRCTLTQVGALLDEKGYGIAMRKNWPYRDTLSQAVLEMQEQGLLTK 774
                   |:|   ::......|.|.:|...|.... |..|.|..|:|:.|:.|:|..:..|||..
  Fly   518 IDRMYRLLLE---LQMDEAEFCDLQEVMFNLPYDS-GSVMPKGSPWREHLAHALLHFRATGLLQY 578

  Fly   775 MKTKWWQEKRGGGACSDADEDSGAVALEISNLGGVFLVMGVGSFFGIFVSLLEMVL 830
            ...||...:..   ||........|.||  :.......:.:.......|.|||:.|
  Fly   579 NDKKWMVRRPD---CSLFKTSQAEVDLE--HFAPALFALALAMVASALVFLLELFL 629

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Grik	NP_001262788.1	PBP1_iGluR_Kainate	37..391	CDD:107377	16/85 (19%)
		ANF_receptor	53..374	CDD:279440	11/45 (24%)
		Periplasmic_Binding_Protein_Type_2	411..781	CDD:304360	95/409 (23%)
		Lig_chan	543..816	CDD:278489	70/299 (23%)
Ir84a	NP_649720.2	nt_trans	<54..>112	CDD:294020
		Periplasmic_Binding_Protein_Type_2	222..583	CDD:304360	93/407 (23%)
		Lig_chan	355..602	CDD:278489	68/284 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462821
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940