DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Grik and gria4a

DIOPT Version :9

Sequence 1:	NP_001262788.1	Gene:	Grik / 42476	FlyBaseID:	FBgn0038840	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	NP_999971.1	Gene:	gria4a / 407735	ZFINID:	ZDB-GENE-020125-7	Length:	898	Species:	Danio rerio

Alignment Length:	922	Identity:	300/922 - (32%)
Similarity:	459/922 - (49%)	Gaps:	113/922 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 GLVYENTDPDLEKIFHLAI------SKANEENEDLQLHGVSVSIEPGNSFETSKKLCKMLRQNLV 95
            ||...|||.:. ..|.|||      ..|.|...:|..|  ..:||..|||..:...|....:.:.
Zfish    26 GLFIRNTDQEY-TAFRLAIFLHNTSPNATEAPFNLVPH--VDNIETANSFAVTNAFCSQYSRGVF 87

  Fly    96 AVFGPTSNLAARHAMSICDAKELPFLDTRWDFGAQLPT---INLHPHPATLGVALRDMVVALGWE 157
            |:||.....:.....|.|.|..:..:..  .|.|:..|   :.|.|   ::..||..::....|.
Zfish    88 AIFGLYDKRSVHTLTSFCSALHISLVTP--SFPAEGETQFVLQLRP---SIRGALLSLLDHYDWS 147

  Fly   158 SFTIIYESGEYLPTVRELLQMYGTAGPTVTVRRYELDLNGNYRNVLRRIRNADDFSFVVVGSMAT 222
            .|..:|::......::.:::..|..|..|:....|...:.:||.:|..:....:..||:......
Zfish   148 RFVFLYDTDRGYAVLQAIMEKAGQNGWQVSAICVENFNDASYRRLLEDLDRRQEKKFVIDLEAER 212

  Fly   223 LPEFFKQAQQVGLVTSDYRYIIGNLDWHTMDLEPYQHAGTNITGLRLVSPDSEQVQEVAK---AL 284
            |....:|...||.....|.||:.||.:..:.||.:.|.|.|:||.:||......|.::.:   .|
Zfish   213 LQNILEQIVSVGKHVKGYHYIVANLGFKDISLERFMHGGANVTGFQLVDFSKPMVIKLMQRWNKL 277

  Fly   285 YESEEPFQNVSCPLTNSMALVYDGVQLLAETYKHVNFRPVALS---------CNDDSAWDKGYTL 340
            .:.|.|  ....|...:.:|.||||.::||.::::..:.:.:|         .|..:.|::|..:
Zfish   278 DQREYP--GSESPPRYTSSLTYDGVLVMAEAFRNLRRQKIDISRRGNAGDCLANPAAPWNQGIDM 340

  Fly   341 VNYMKSLTLNGLTGPIRFDYEGLRTDFKLEVIELAVSGMQKIGQWS--------------GEDGF 391
            ...:|.:.:.||||.|:||:.|.|.::.::|.||..:|.:|||.|:              |.|..
Zfish   341 ERTLKQVRIQGLTGNIQFDHYGRRVNYTMDVFELKSNGPRKIGYWNDLDKLVLVQNELSMGNDSA 405

  Fly   392 QENRPAPAHSLEPDMRSLVNKSFVVITAISE-PYGMLKETSEKLEGNDQFEGFGIELIDELSKKL 455
            .|||.                  |::|.|.| ||.|||:..|..|||:||||:.::|..|::|.:
Zfish   406 MENRT------------------VIVTTIMEGPYVMLKKNWEMYEGNEQFEGYCVDLASEVAKHI 452

  Fly   456 GFSYTWRLQEDNKYGGIDPKTGEWNGMLREIIDSRADMGITDLTMTSERESGVDFTIPFMSLGIG 520
            |..|...:..|.|||..||:|..||||:.|::..:|::.:..|.:|..||..:||:.|||||||.
Zfish   453 GIKYKISIVLDGKYGARDPETKIWNGMVGELVYGKAEIAVAPLAITLVREEVIDFSKPFMSLGIS 517

  Fly   521 ILFRKPMKEPPKLFSFMSPFSGEVWLWLGLAYMGVSISMFVLGRLSPAEWDNPYPCIEEPTE--- 582
            |:.:||.|..|.:|||:.|.:.|:|:.:..||:|||:.:|::.|.||.||..     |||.|
Zfish   518 IMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHT-----EEPEEGSD 577

  Fly   583 ------LENQFSFANCLWFSIGALLQQGSELAPKAYSTRAVAASWWFFTLILVSSYTANLAAFLT 641
                  ..|:|...|.||||:||.:|||.:..|::.|.|.|...|||||||::||||||||||||
Zfish   578 GPPSDQPPNEFGIFNSLWFSLGAFMQQGCDFTPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLT 642

  Fly   642 VESLVTPINDADDLSKNKGGVNYGAKIGGATFNFFKESNYPTYQRMYEFMRD-NPQYMTNTNQEG 705
            ||.:|:||..|:||:| :..:.||....|:|..||:.|....|::|:.:|:. .|...|.|..||
Zfish   643 VERMVSPIESAEDLAK-QTEIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKSAEPTVFTKTTAEG 706

  Fly   706 VDRVENS--NYAFLMESTTIEYITERR-CTLTQVGALLDEKGYGIAMRKNWPYRDTLSQAVLEMQ 767
            |.||..|  .||||:|||..||..:|: |...:||..||.||||:|..|.......::.|||::.
Zfish   707 VARVRKSKGKYAFLLESTMNEYTEQRKPCDTMKVGGNLDSKGYGVATPKGSQLGTPVNLAVLKLS 771

  Fly   768 EQGLLTKMKTKWWQEKRGGGACSDAD---EDSGAVALEISNLGGVFLVMGVGSFFGIFVSLLEMV 829
            |.|:|.|:|.|||.:|   |.|...|   :|..:.||.:||:.|||.::..|....:.|:|:|..
Zfish   772 EAGVLDKLKNKWWYDK---GECGPKDSGSKDKSSQALSLSNVAGVFYILVGGLGLAMLVALVEFC 833

  Fly   830 LGVKERSDENQVSFKTELLDEIRFILQCSGNTKAVKYPKNSSRSNASSKSKGSSMSVDSLPEDTS 894
            ...:..:.:.:::|...:.::.|  |..:|                   |.|.:..|  |..|..
Zfish   834 YKSRAEAKKLKLTFSEAMRNKAR--LSITG-------------------SLGENGRV--LTPDCP 875

  Fly   895 EADASG-KHNHG 905
            :|..|| .:.||
Zfish   876 KAVHSGPSYRHG 887

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Grik	NP_001262788.1	PBP1_iGluR_Kainate	37..391	CDD:107377	98/388 (25%)
		ANF_receptor	53..374	CDD:279440	83/341 (24%)
		Periplasmic_Binding_Protein_Type_2	411..781	CDD:304360	168/383 (44%)
		Lig_chan	543..816	CDD:278489	124/288 (43%)
gria4a	NP_999971.1	PBP1_iGluR_AMPA_GluR4	23..393	CDD:107383	96/376 (26%)
		ANF_receptor	34..375	CDD:279440	85/350 (24%)
		PBP2_iGluR_AMPA_GluR4	408..790	CDD:270445	173/408 (42%)
		Lig_chan	540..821	CDD:278489	124/289 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591300
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.850