DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Grik and Nmdar1

DIOPT Version :9

Sequence 1:	NP_001262788.1	Gene:	Grik / 42476	FlyBaseID:	FBgn0038840	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	NP_730940.1	Gene:	Nmdar1 / 40665	FlyBaseID:	FBgn0010399	Length:	997	Species:	Drosophila melanogaster

Alignment Length:	947	Identity:	234/947 - (24%)
Similarity:	397/947 - (41%)	Gaps:	187/947 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 PLGFILTSLLLAFPGCRGER---------TNVGLVYENTDPDLEKIFHLAISKANEENE----DL 65
            || |.|..:||..|....:|         .|:|.|..|:|.  |:.|...|...|.:.:    .:
  Fly    11 PL-FGLAIVLLVAPIDAAQRHTASDNPSTYNIGGVLSNSDS--EEHFSTTIKHLNFDQQYVPRKV 72

  Fly    66 QLHGVSVSIEPGNSFETSKKLCKMLRQNLVAVFGPTSNLAARHAMSICDAKELPFLDTRWDFGAQ 130
            ..:..::.::. |..:|...:|..|.:|.|..      :...|..:..|...          .|.
  Fly    73 TYYDKTIRMDK-NPIKTVFNVCDKLIENRVYA------VVVSHEQTSGDLSP----------AAV 120

  Fly   131 LPTINLHPHPATLGVALRDMVVALGWESFTIIYESGEYLPTVREL-------LQMYGTAGPTVTV 188
            ..|...:..| .:|::.||  .|...::..:     .:|.||...       |:|......|..:
  Fly   121 SYTSGFYSIP-VIGISSRD--AAFSDKNIHV-----SFLRTVPPYYHQADVWLEMLSHFAYTKVI 177

  Fly   189 RRYELDLNGNYRNVLRRIRNADDFSFVVVGSMAT---LPEF-------------FKQAQ-QVGLV 236
            ..:..|.:|  |.:|.|.:......:..|...||   :.||             .|.|| :|.|:
  Fly   178 IIHSSDTDG--RAILGRFQTTSQTYYDDVDVRATVELIVEFEPKLESFTEHLIDMKTAQSRVYLM 240

  Fly   237 ---TSDYRYIIGNLDWHTMDLEPYQHAGT-NITGLRLVSPDSEQVQEVAKALYESEEPFQNVSCP 297
               |.|.:.|             ::.||. |:||...|...:||      ||:.:..|...:...
  Fly   241 YASTEDAQVI-------------FRDAGEYNMTGEGHVWIVTEQ------ALFSNNTPDGVLGLQ 286

  Fly   298 LTNS---MALVYDGVQLLAETYKH-VNFRPVALSCND--DSA--WDKGYTLVNYMKSLTLNGLTG 354
            |.::   ...:.|.|.:||...|. ::...:|.:..|  |||  |:.|..|..|:||..:.|.||
  Fly   287 LEHAHSDKGHIRDSVYVLASAIKEMISNETIAEAPKDCGDSAVNWESGKRLFQYLKSRNITGETG 351

  Fly   355 PIRFDYEGLRTDFKLEVIELAVSGMQK---IGQWSGEDGFQENRPAPAHSLEPDMRSLVNKSFVV 416
            .:.||..|.|.....:||.  :...||   :|::|.:            |:...||..:|.|.::
  Fly   352 QVAFDDNGDRIYAGYDVIN--IREQQKKHVVGKFSYD------------SMRAKMRMRINDSEII 402

  Fly   417 ITAIS--EPYGMLKETSEKL-------------EGNDQF------------------------EG 442
            .....  :|.|::..|..:|             .|:|:|                        .|
  Fly   403 WPGKQRRKPEGIMIPTHLRLLTIEEKPFVYVRRMGDDEFRCEPDERPCPLFNNSDATANEFCCRG 467

  Fly   443 FGIELIDELSKKLGFSYTWRLQEDNKYGG--IDPKTG------EWNGMLREIIDSRADMGITDLT 499
            :.|:|:.||||::.|:|...|..|.::|.  :...||      ||.|::.|:::.||||.:..||
  Fly   468 YCIDLLIELSKRINFTYDLALSPDGQFGHYILRNNTGAMTLRKEWTGLIGELVNERADMIVAPLT 532

  Fly   500 MTSERESGVDFTIPFMSLGIGILFRKPMKEPPKLFSFMSPFSGEVWLWLGLAYMGVSISMFVLGR 564
            :..||...::|:.||...||.||.:||.:. ..|.||:.|||..:|:.:.::...|::.:::|.|
  Fly   533 INPERAEYIEFSKPFKYQGITILEKKPSRS-STLVSFLQPFSNTLWILVMVSVHVVALVLYLLDR 596

  Fly   565 LSPAEWDNPYPCIEEPTELENQFSFANCLWFSIGALLQQG-SELAPKAYSTRAVAASWWFFTLIL 628
            .||.   ..:......:..|...:.::.:||:.|.||..| .|..|:::|.|.:...|..|.:|:
  Fly   597 FSPF---GRFKLSHSDSNEEKALNLSSAVWFAWGVLLNSGIGEGTPRSFSARVLGMVWAGFAMII 658

  Fly   629 VSSYTANLAAFLTVE---SLVTPINDADDLSKNKGGVNYGAKIGGATFNFFKE----SNYPTYQR 686
            |:||||||||||.:|   :.::.|||| .|......:......|.:...:|:.    ||
  Fly   659 VASYTANLAAFLVLERPKTKLSGINDA-RLRNTMENLTCATVKGSSVDMYFRRQVELSN------ 716

  Fly   687 MYEFMRDNPQYMTNTNQEGVDRVENSN-YAFLMESTTIEYITERRCTLTQVGALLDEKGYGIAMR 750
            ||..|..| .|.  |.::.:..|:... .||:.:|:.:||...:.|.|...|.|....||||.::
  Fly   717 MYRTMEAN-NYA--TAEQAIQDVKKGKLMAFIWDSSRLEYEASKDCELVTAGELFGRSGYGIGLQ 778

  Fly   751 KNWPYRDTLSQAVLEMQEQGLLTKMKTKWWQEKRGGGACSDADEDSGAVALEISNLGGVFLVMGV 815
            |..|:.|.::.|:||..|.|.:.|:..:|.........|...::....:.|:  |:.|||:::||
  Fly   779 KGSPWTDAVTLAILEFHESGFMEKLDKQWIFHGHVQQNCELFEKTPNTLGLK--NMAGVFILVGV 841

  Fly   816 GSFFGIFVSLLEMVLGVKERSDENQVSFKTELLDEIR 852
            |...|:.:.::|::....:...:.::.......|:.|
  Fly   842 GIAGGVGLIIIEVIYKKHQVKKQKRLDIARHAADKWR 878

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Grik	NP_001262788.1	PBP1_iGluR_Kainate	37..391	CDD:107377	88/396 (22%)
		ANF_receptor	53..374	CDD:279440	78/360 (22%)
		Periplasmic_Binding_Protein_Type_2	411..781	CDD:304360	121/425 (28%)
		Lig_chan	543..816	CDD:278489	78/281 (28%)
Nmdar1	NP_730940.1	PBP1_iGluR_NMDA_NR1	12..405	CDD:107374	101/455 (22%)
		ANF_receptor	58..371	CDD:279440	78/360 (22%)
		PBP2_iGluR_NMDA_Nr1	417..818	CDD:270437	117/414 (28%)
		HisJ	451..>558	CDD:223904	33/106 (31%)
		Periplasmic_Binding_Protein_Type_2	<516..651	CDD:304360	41/138 (30%)
		Lig_chan	575..838	CDD:278489	77/277 (28%)
		CaM_bdg_C0	854..882	CDD:287524	2/25 (8%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462862
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm1027
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.940