DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Grik and gria3b

DIOPT Version :9

Sequence 1:	NP_001262788.1	Gene:	Grik / 42476	FlyBaseID:	FBgn0038840	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	NP_938174.1	Gene:	gria3b / 368416	ZFINID:	ZDB-GENE-030616-53	Length:	883	Species:	Danio rerio

Alignment Length:	884	Identity:	280/884 - (31%)
Similarity:	453/884 - (51%)	Gaps:	80/884 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 MISTEASFPLGFILTSLLLAFPGCRGERTNVGLVY-----------------ENTDPDL-EKIFH 52
            |..:...|.|....|| |..||    .:.|:|.::                 .||:.:: ||.||
Zfish     1 MTQSALIFLLWLFGTS-LAGFP----NQINIGGLFMRSTVQEHSAFRFAVQLYNTNQNMTEKPFH 60

  Fly    53 LAISKANEENEDLQLHGVSVSIEPGNSFETSKKLCKMLRQNLVAVFGPTSNLAARHAMSICDAKE 117
            |   ..|.:|           :|..|||..:...|....:.:.|:||.....:.....|.|.|..
Zfish    61 L---NYNVDN-----------LESSNSFSVTHAFCSQFSRGVYAIFGFYDKKSMNTLTSFCGALH 111

  Fly   118 LPFLDTRWDFGAQLPTINLHPHPATLGVALRDMVVALGWESFTIIYESGEYLPTVRELLQMYGTA 182
            ..|:...:...:.:..: :...|...|..| .::....|:.|..:|::......::.:::.....
Zfish   112 TSFVTPSYPIDSDVQFV-IQMRPPLKGAVL-SLLSHYKWDKFVYLYDTDRGFSILQAIMEAAVAN 174

  Fly   183 GPTVTVRRY-ELDLNGNYRNVLRRIRNADDFSFVVVGSMATLPEFFKQAQQVGLVTSDYRYIIGN 246
            ...||.|.. .:.....:|.::..:....:..:::...:..:....:|...:|..:..|.|||.|
Zfish   175 NWQVTARSVGSITDPQEFRRIIEEMDRRQEKRYLIDCEVDRINVILEQVVTLGKNSRGYHYIIAN 239

  Fly   247 LDWHTMDLEPYQHAGTNITGLRLVSPDSEQVQEVAK---ALYESEEPFQNVSCPLTNSMALVYDG 308
            |.:..:.|:.....|.||:|.::::|::..||:..:   .|.|.|.| :..:.||..:.||.||.
Zfish   240 LGFTNISLDKVFLGGANISGFQIINPENLVVQQFLQRWDRLDEREFP-EAKNTPLKYTSALSYDA 303

  Fly   309 VQLLAETYKHVNFRPVALS---------CNDDSAWDKGYTLVNYMKSLTLNGLTGPIRFDYEGLR 364
            :.::||.::::..:.|.:|         .|....|.:|..:...:|.:.:.|:||.|:||..|.|
Zfish   304 ILVIAEAFRYLRRQRVDVSRRGSAGDCLANPAVPWSQGIDIERALKMVQVQGMTGNIQFDSFGRR 368

  Fly   365 TDFKLEVIELAVSGMQKIGQWSGEDGFQENRPAPAHSLEPDMRSLVNKSFVVITAISEPYGMLKE 429
            |::.::|.|:...|.:|||.|:..:.|..   ........|..|:.|::.||.|.:..||.|.|:
Zfish   369 TNYTIDVYEMKTGGPRKIGYWNEFERFVN---IMDQQFTNDSSSVENRTIVVTTIMEAPYVMYKK 430

  Fly   430 TSEKLEGNDQFEGFGIELIDELSKKLGFSYTWRLQEDNKYGGIDPKTGEWNGMLREIIDSRADMG 494
            ....||||:::||:.::|..|::|.:|..|...:..|.|||..||:|..||||:.|::..|||:.
Zfish   431 NHMHLEGNEKYEGYCVDLASEIAKHVGIKYRLSIVMDGKYGARDPETKSWNGMVGELVYGRADIA 495

  Fly   495 ITDLTMTSERESGVDFTIPFMSLGIGILFRKPMKEPPKLFSFMSPFSGEVWLWLGLAYMGVSISM 559
            :..||:|..||..:||:.|||||||.|:.:||.|..|.:|||:.|.:.|:|:.:..||:|||:.:
Zfish   496 VAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVL 560

  Fly   560 FVLGRLSPAEWD--------NPYPCIEEPTELENQFSFANCLWFSIGALLQQGSELAPKAYSTRA 616
            |::.|.||.||.        :|    :.|.:..|.|...|.||||:||.:|||.:::|::.|.|.
Zfish   561 FLVSRFSPYEWQLDETDEVKDP----QTPPDPPNDFGIFNSLWFSLGAFMQQGCDISPRSLSGRI 621

  Fly   617 VAASWWFFTLILVSSYTANLAAFLTVESLVTPINDADDLSKNKGGVNYGAKIGGATFNFFKESNY 681
            |...|||||||::||||||||||||||.:|:||..|:||:| :..:.||....|:|..||:.|..
Zfish   622 VGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAK-QTEIAYGTLDSGSTKEFFRRSKI 685

  Fly   682 PTYQRMYEFMRD-NPQYMTNTNQEGVDRVENS--NYAFLMESTTIEYITERR-CTLTQVGALLDE 742
            ..|::|:.:|:. .|.....|..:||.||..|  .:|||:|||..|||.:|: |...:||..||.
Zfish   686 AVYEKMWSYMKSAEPSVFAKTTPDGVARVRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDS 750

  Fly   743 KGYGIAMRKNWPYRDTLSQAVLEMQEQGLLTKMKTKWWQEKRGGGACSDADEDS--GAVALEISN 805
            ||||:|..|....|:.::.|||::.|||||.|:|.|||.:|   |.|.....||  ...||.:||
Zfish   751 KGYGVATPKGSALRNAVNLAVLKLNEQGLLDKLKNKWWYDK---GECGSGGGDSKDKTSALSLSN 812

  Fly   806 LGGVFLVMGVGSFFGIFVSLLEMVLGVKERSDENQVSFK 844
            :.|||.::..|....:.|:|:|..  .|.|::..::..:
Zfish   813 VAGVFYILVGGLGLAMMVALIEFC--YKSRAEAKRLKLE 849

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Grik	NP_001262788.1	PBP1_iGluR_Kainate	37..391	CDD:107377	82/384 (21%)
		ANF_receptor	53..374	CDD:279440	69/333 (21%)
		Periplasmic_Binding_Protein_Type_2	411..781	CDD:304360	167/381 (44%)
		Lig_chan	543..816	CDD:278489	123/286 (43%)
gria3b	NP_938174.1	Periplasmic_Binding_Protein_Type_1	25..396	CDD:299141	83/387 (21%)
		ANF_receptor	36..379	CDD:279440	76/359 (21%)
		PBP2_iGluR_AMPA	412..794	CDD:270433	170/389 (44%)
		Lig_chan	544..824	CDD:278489	123/287 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591341
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.850