Protein Alignment Grik and clumsy

DIOPT Version :10

• Sequence 1: NP_001262788.1
• Gene: Grik / 42476
• FlyBaseID: FBgn0038840
• Length: 907
• Species: Drosophila melanogaster
• Sequence 2: NP_001036373.1
• Gene: clumsy / 35394
• FlyBaseID: FBgn0026255
• Length: 1002
• Species: Drosophila melanogaster
• Alignment Length: 930
• Identity: 331/930 - (35%)
• Similarity: 505/930 - (54%)
• Gaps: 51/930 - (5%)

  Fly    17 FILTSLLLAFPGCRG-ERTN--VGLVYENTDPDLEKIFHLAISKANEENEDLQLHGVSVSIEPGN 78
            |:...||:|.|.... :|:.  ||.::.:...:.|..|..|:.:||....:::|..:.|.....:
  Fly     5 FLTHFLLIALPVLADIDRSQFMVGSIFTSDKDESEIAFRTAVDRANILERNVELVPIVVYANTDD 69

  Fly    79 SFETSKKLCKMLRQNLVAVFGPTSNLAARHAMSICDAKELPFLDTRWDFGAQLP-------TINL 136
            ||...|.:|.::.|.::|:|||::..::....||||..::|.:...|.....:|       |:|:
  Fly    70 SFIMEKMVCNLISQGVIAIFGPSTGSSSDIIASICDTLDIPHIVYDWIPNESIPDREHSTMTLNV 134

  Fly   137 HPHPATLGVALRDMVVALGWESFTIIYESGEYLPTVRELLQMYGTAGPTVTVRRYELDLNGNYRN 201
            ||....|...|.::|.:..|.|||::||:.:.|..::::||:........||:  :|....::|.
  Fly   135 HPDNLLLSQGLAEIVQSFAWRSFTVVYETDKELQQLQDILQVGEPISNPTTVK--QLGPGDDHRP 197

  Fly   202 VLRRIRNADDFSFVVVGSMATLPEFFKQAQQVGLVTSDYRYIIGNLDWHTMDLEPYQHAGTNITG 266
            .|:.|:.:.|...::..:...|.:..:||.::.::.......|..||.|::|.........|||.
  Fly   198 FLKEIKLSTDNCLILHCAPDNLLKILQQANELKMLGEYQSVFIPLLDTHSIDFGELSGVEANITT 262

  Fly   267 LRLVSPDSEQVQEVAKALYESEEP----FQNVSCPLTNSMALVYDGVQLLAETYKHVN-FRPVA- 325
            :||:.|....|:.|.....|.|:.    |:.....:.:.|.|:.|.|.|.::....:. |..:.
  Fly   263 VRLMDPSDFHVKNVVHDWEEREKREGRYFKVDPNRVKSQMILLNDAVWLFSKGLTELGIFEELTA 327

  Fly   326 --LSCNDDSAWDKGYTLVNYMKSLTLNGLTGPIRFDYEGLRTDFKLEVIELAVSGMQKIGQWSGE 388
              |.|.....|..|..::.::|:.:....||.|.|:..|.|:.|.|..:||...|...:..|...
  Fly   328 PDLECRRKKPWPFGKRIIEFIKARSEETSTGRIDFNENGQRSFFTLRFMELNSDGFLDLATWDPV 392

  Fly   389 DGFQENRPAPAHSLEPDMRS-------LVNKSFVVITAISEPYGMLKETSEK--LEGNDQFEGFG 444
            :|..        .|..|..|       |.||:|:|.:.:..|:..|:|..|.  |.||.::||:.
  Fly   393 NGLD--------VLNDDEESEKRVGQKLSNKTFIVSSRLGAPFLTLREPQEGEILTGNSRYEGYS 449

  Fly   445 IELIDELSKKLGFSYTWRLQEDNKYGGIDPKTGEWNGMLREIIDSRADMGITDLTMTSERESGVD 509
            |:||:|::|.|.|.:.:|:..|.|||.::..|..|:|::|::||..||:||.||||||.|...||
  Fly   450 IDLINEIAKMLNFKFEFRMSPDGKYGALNKVTQTWDGIVRQLIDGNADLGICDLTMTSSRRQAVD 514

  Fly   510 FTIPFMSLGIGILFRKPMKEPPKLFSFMSPFSGEVWLWLGLAYMGVSISMFVLGRLSPAEWDNPY 574
            ||.|||:|||.|||.||...|..||||:||||.:||:::|.||:.:|:.:|.|.|::|.:|:||:
  Fly   515 FTPPFMTLGISILFSKPPTPPTDLFSFLSPFSLDVWIYMGSAYLFISLLLFALARMAPDDWENPH 579

  Fly   575 PCIEEPTELENQFSFANCLWFSIGALLQQGSELAPKAYSTRAVAASWWFFTLILVSSYTANLAAF 639
            || :||.|:||.:|..|..|.|||:|:.||.::.|||.|||.|...||||.|::::|||||||||
  Fly   580 PC-KEPEEVENIWSIMNTTWLSIGSLMGQGCDILPKAASTRLVTGMWWFFALMMLNSYTANLAAF 643

  Fly   640 LTVESLVTPINDADDLSKNKGGVNYGAKIGGATFNFFKESNYPTYQRMYEFMRD-NPQYMTNTNQ 703
            ||.......||.|:||:. :..:.|||..||:|..||::||:.|||:|:..|.. :|...|.||.
  Fly   644 LTNSRQANSINSAEDLAA-QSKIKYGAMAGGSTMGFFRDSNFSTYQKMWTAMESASPSVFTKTND 707

  Fly   704 EGVDRVENSN--YAFLMESTTIEYITERRCTLTQVGALLDEKGYGIAMRKNWPYRDTLSQAVLEM 766
            |||:||:...  |||||||||:||..||:|.|.|:|..||.|.|||||..|.|||..:|.|||::
  Fly   708 EGVERVQKGKNLYAFLMESTTLEYNVERKCDLVQIGGWLDYKSYGIAMPFNSPYRKQISAAVLKL 772

  Fly   767 QEQGLLTKMKTKWWQEKRGGGACSDADEDSG-AVALEISNLGGVFLVMGVGSFFGIFVSLLEMVL 830
            .|.|.|.::|.|||:|..|||.|..:|||.| ...|.:.|:||||||:|:|....:.:...|.:.
  Fly   773 GELGQLAELKRKWWKEMHGGGNCEKSDEDGGDTPELGLENVGGVFLVLGLGLLSAMVLGCTEFLW 837

  Fly   831 GVKERSDENQVSFKTELLDEIRFILQCSGNTKAVKYPKNSSRSNASSKS--------KGSSMSVD 887
            .||..:.|.::|.|.....|..|..:....||.|.....|..||:||.|        |...:|:.
  Fly   838 NVKSVAIEEKISLKEAFKSEALFAARIWITTKPVHTSSESGSSNSSSSSSSRSKHSFKSQGLSMK 902

  Fly   888 SLPEDTSEADASGKHNHGKK 907
            ||.....:...:..|:..||
  Fly   903 SLKSSGYQDVEASVHSKLKK 922

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Grik	NP_001262788.1	PBP1_iGluR_Kainate	35..395	CDD:380605	91/376 (24%)
		Periplasmic_Binding_Protein_Type_2	411..781	CDD:473866	186/374 (50%)
clumsy	NP_001036373.1	PBP1_iGluR_Kainate	27..397	CDD:380605	91/379 (24%)
		PBP2_iGluR_Kainate	414..787	CDD:270432	186/374 (50%)