DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Grik and clumsy

DIOPT Version :9

Sequence 1:	NP_001262788.1	Gene:	Grik / 42476	FlyBaseID:	FBgn0038840	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	NP_001036373.1	Gene:	clumsy / 35394	FlyBaseID:	FBgn0026255	Length:	1002	Species:	Drosophila melanogaster

Alignment Length:	930	Identity:	331/930 - (35%)
Similarity:	505/930 - (54%)	Gaps:	51/930 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 FILTSLLLAFPGCRG-ERTN--VGLVYENTDPDLEKIFHLAISKANEENEDLQLHGVSVSIEPGN 78
            |:...||:|.|.... :|:.  ||.::.:...:.|..|..|:.:||....:::|..:.|.....:
  Fly     5 FLTHFLLIALPVLADIDRSQFMVGSIFTSDKDESEIAFRTAVDRANILERNVELVPIVVYANTDD 69

  Fly    79 SFETSKKLCKMLRQNLVAVFGPTSNLAARHAMSICDAKELPFLDTRWDFGAQLP-------TINL 136
            ||...|.:|.::.|.::|:|||::..::....||||..::|.:...|.....:|       |:|:
  Fly    70 SFIMEKMVCNLISQGVIAIFGPSTGSSSDIIASICDTLDIPHIVYDWIPNESIPDREHSTMTLNV 134

  Fly   137 HPHPATLGVALRDMVVALGWESFTIIYESGEYLPTVRELLQMYGTAGPTVTVRRYELDLNGNYRN 201
            ||....|...|.::|.:..|.|||::||:.:.|..::::||:........||:  :|....::|.
  Fly   135 HPDNLLLSQGLAEIVQSFAWRSFTVVYETDKELQQLQDILQVGEPISNPTTVK--QLGPGDDHRP 197

  Fly   202 VLRRIRNADDFSFVVVGSMATLPEFFKQAQQVGLVTSDYRYIIGNLDWHTMDLEPYQHAGTNITG 266
            .|:.|:.:.|...::..:...|.:..:||.::.::.......|..||.|::|.........|||.
  Fly   198 FLKEIKLSTDNCLILHCAPDNLLKILQQANELKMLGEYQSVFIPLLDTHSIDFGELSGVEANITT 262

  Fly   267 LRLVSPDSEQVQEVAKALYESEEP----FQNVSCPLTNSMALVYDGVQLLAETYKHVN-FRPVA- 325
            :||:.|....|:.|.....|.|:.    |:.....:.:.|.|:.|.|.|.::....:. |..:.
  Fly   263 VRLMDPSDFHVKNVVHDWEEREKREGRYFKVDPNRVKSQMILLNDAVWLFSKGLTELGIFEELTA 327

  Fly   326 --LSCNDDSAWDKGYTLVNYMKSLTLNGLTGPIRFDYEGLRTDFKLEVIELAVSGMQKIGQWSGE 388
              |.|.....|..|..::.::|:.:....||.|.|:..|.|:.|.|..:||...|...:..|...
  Fly   328 PDLECRRKKPWPFGKRIIEFIKARSEETSTGRIDFNENGQRSFFTLRFMELNSDGFLDLATWDPV 392

  Fly   389 DGFQENRPAPAHSLEPDMRS-------LVNKSFVVITAISEPYGMLKETSEK--LEGNDQFEGFG 444
            :|..        .|..|..|       |.||:|:|.:.:..|:..|:|..|.  |.||.::||:.
  Fly   393 NGLD--------VLNDDEESEKRVGQKLSNKTFIVSSRLGAPFLTLREPQEGEILTGNSRYEGYS 449

  Fly   445 IELIDELSKKLGFSYTWRLQEDNKYGGIDPKTGEWNGMLREIIDSRADMGITDLTMTSERESGVD 509
            |:||:|::|.|.|.:.:|:..|.|||.::..|..|:|::|::||..||:||.||||||.|...||
  Fly   450 IDLINEIAKMLNFKFEFRMSPDGKYGALNKVTQTWDGIVRQLIDGNADLGICDLTMTSSRRQAVD 514

  Fly   510 FTIPFMSLGIGILFRKPMKEPPKLFSFMSPFSGEVWLWLGLAYMGVSISMFVLGRLSPAEWDNPY 574
            ||.|||:|||.|||.||...|..||||:||||.:||:::|.||:.:|:.:|.|.|::|.:|:||:
  Fly   515 FTPPFMTLGISILFSKPPTPPTDLFSFLSPFSLDVWIYMGSAYLFISLLLFALARMAPDDWENPH 579

  Fly   575 PCIEEPTELENQFSFANCLWFSIGALLQQGSELAPKAYSTRAVAASWWFFTLILVSSYTANLAAF 639
            || :||.|:||.:|..|..|.|||:|:.||.::.|||.|||.|...||||.|::::|||||||||
  Fly   580 PC-KEPEEVENIWSIMNTTWLSIGSLMGQGCDILPKAASTRLVTGMWWFFALMMLNSYTANLAAF 643

  Fly   640 LTVESLVTPINDADDLSKNKGGVNYGAKIGGATFNFFKESNYPTYQRMYEFMRD-NPQYMTNTNQ 703
            ||.......||.|:||:. :..:.|||..||:|..||::||:.|||:|:..|.. :|...|.||.
  Fly   644 LTNSRQANSINSAEDLAA-QSKIKYGAMAGGSTMGFFRDSNFSTYQKMWTAMESASPSVFTKTND 707

  Fly   704 EGVDRVENSN--YAFLMESTTIEYITERRCTLTQVGALLDEKGYGIAMRKNWPYRDTLSQAVLEM 766
            |||:||:...  |||||||||:||..||:|.|.|:|..||.|.|||||..|.|||..:|.|||::
  Fly   708 EGVERVQKGKNLYAFLMESTTLEYNVERKCDLVQIGGWLDYKSYGIAMPFNSPYRKQISAAVLKL 772

  Fly   767 QEQGLLTKMKTKWWQEKRGGGACSDADEDSG-AVALEISNLGGVFLVMGVGSFFGIFVSLLEMVL 830
            .|.|.|.::|.|||:|..|||.|..:|||.| ...|.:.|:||||||:|:|....:.:...|.:.
  Fly   773 GELGQLAELKRKWWKEMHGGGNCEKSDEDGGDTPELGLENVGGVFLVLGLGLLSAMVLGCTEFLW 837

  Fly   831 GVKERSDENQVSFKTELLDEIRFILQCSGNTKAVKYPKNSSRSNASSKS--------KGSSMSVD 887
            .||..:.|.::|.|.....|..|..:....||.|.....|..||:||.|        |...:|:.
  Fly   838 NVKSVAIEEKISLKEAFKSEALFAARIWITTKPVHTSSESGSSNSSSSSSSRSKHSFKSQGLSMK 902

  Fly   888 SLPEDTSEADASGKHNHGKK 907
            ||.....:...:..|:..||
  Fly   903 SLKSSGYQDVEASVHSKLKK 922

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Grik	NP_001262788.1	PBP1_iGluR_Kainate	37..391	CDD:107377	89/368 (24%)
		ANF_receptor	53..374	CDD:279440	82/335 (24%)
		Periplasmic_Binding_Protein_Type_2	411..781	CDD:304360	186/374 (50%)
		Lig_chan	543..816	CDD:278489	139/276 (50%)
clumsy	NP_001036373.1	PBP1_iGluR_Kainate	26..396	CDD:107377	91/371 (25%)
		ANF_receptor	39..379	CDD:279440	85/341 (25%)
		PBP2_iGluR_Kainate	414..787	CDD:270432	186/374 (50%)
		Lig_chan	548..812	CDD:278489	131/265 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462600
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D17567at33392
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm1027
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	P	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	8	7.850