DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Grik and GluRIIB

DIOPT Version :9

Sequence 1:	NP_001262788.1	Gene:	Grik / 42476	FlyBaseID:	FBgn0038840	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	NP_523485.3	Gene:	GluRIIB / 33789	FlyBaseID:	FBgn0020429	Length:	913	Species:	Drosophila melanogaster

Alignment Length:	939	Identity:	281/939 - (29%)
Similarity:	456/939 - (48%)	Gaps:	96/939 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 LTSLLLAFPGCRGERT---NVGLVYENTDPDLEKIFHLAISKANEENEDLQLHGVSVSIEPGNSF 80
            |..|.||......|.|   .:|.::.:|:..|...|..|:.:.|..|..|:|..:...:...:|.
  Fly     7 LVLLALAIASGANEDTLVIKIGAIFFDTEMKLADAFSAALEEVNAINPALKLDAIKRYVTVDDSI 71

  Fly    81 ETSKKLCKMLRQNLVAVFGPTSNLAARHAMSICDAKELPFLDTRWD--------FGAQLPTINLH 137
            ......|.::...:.|:|||:|...:.....:|:...:|.|...|.        ...|| |:|:.
  Fly    72 VLQDISCDLIGSGVAAIFGPSSKTNSDIVEVLCNMTGIPHLQFDWHPQQSNRERMNHQL-TVNVA 135

  Fly   138 PHPATLGVALRDMVVA--LGWESFTIIYESGEYLPTVRELL---QMYGTAGPTVTVRRYELDLNG 197
            |....|..|..|::.:  ..|:||||.||...:|..::.:|   |:: .||    ::..|.:...
  Fly   136 PMELFLSAAFSDILASKTFDWKSFTIAYERSSHLIRLQHILAWKQLH-KAG----IKMQEFERGD 195

  Fly   198 NYRNVLRRIRNADDFSFVVVGSMA-TLPEFFKQAQQVGLVTSDYRYIIGNLDWHTMDLEPY--QH 259
            :||.:.:||.||.: .||::...: .|.:....:....:..|.....:.|||.|...::.:  :.
  Fly   196 DYRILWKRINNARE-KFVLLDCPSDILVDVINASIGYNMTGSFNHLFLTNLDTHLSGIDGFYSRD 259

  Fly   260 AGTNITGLRLVSPDSEQVQEVAKALYESEEPFQNVSCPLTNSMA--LVYDGVQLLAETYKHVNFR 322
            ....:..:|:.:       .|...:::..:.|.|......:|:.  ||||.:.|.......::.|
  Fly   260 FTVAVAAVRIRT-------YVPPPVHDEIDVFDNSVDTRFSSLGSQLVYDSIVLFYNALLEISQR 317

  Fly   323 P----VALSCNDDSAWDKGYTLVNYMKSLTLNGLTGP-----IRFDYEGLRTDFKLEVIELAVSG 378
            |    ...||. ...|..|..||..||.:|...:..|     ::.:.:|.|.||.|||....:..
  Fly   318 PGFYIPNFSCG-RGFWQPGPRLVEQMKQITPKMVKPPFKTQRLQINADGQREDFNLEVYNPIIDR 381

  Fly   379 MQKIGQWSGE---DGFQENRPAPAHSLEPDMRSLVNKS--------FVVITAISEPYGMLKETSE 432
            :..|  |:.|   ..|::.|.....:|:  .:.|.||.        :.|.|.:.:||...:|..|
  Fly   382 VTHI--WNKEFQLVDFEKLRENSTQALK--QKRLQNKEDFSQKPIRYTVATRVGKPYFSWREEPE 442

  Fly   433 KL--EGNDQFEGFGIELIDELSKKLGFSYTWRLQEDNKYGGIDPKTGEWNGMLREIIDSRADMGI 495
            .:  |||::|||:.::||..|:::..|.:.:....|||||..|..|.||:|::|::||:.|.:||
  Fly   443 GVHYEGNERFEGYAVDLIYMLAQECKFDFNFEPVRDNKYGSYDANTDEWDGIIRQLIDNNAQIGI 507

  Fly   496 TDLTMTSERESGVDFTIPFMSLGIGIL-FRKPMKEPPK--LFSFMSPFSGEVWLWLGLAYMGVSI 557
            .|||:|..|.|.||||:|||.|||.|| :::|   |||  :::|::|::.||||::.:|.|..:.
  Fly   508 CDLTITQARRSVVDFTVPFMQLGISILSYKEP---PPKADIYAFLNPYNAEVWLFVMIAMMITAF 569

  Fly   558 SMFVLGRLSPAEWDNPYPCIEEPTELENQFSFANCLWFSIGALLQQGSELAPKAYSTRAVAASWW 622
            ::...||:...|||.|...:....|.:|.:..:|.||..:|::|.||.:|.|:....|.:.|.||
  Fly   570 ALIFTGRIDQYEWDQPVENVNREMERQNIWHLSNALWLVLGSMLNQGCDLLPRGLPMRLLTAFWW 634

  Fly   623 FFTLILVSSYTANLAAFLTVESLVTPINDADDL-SKNKGGVNYGAKIGGATFNFFKESNYPTYQR 686
            .|.|::..:|.|.||||:|...:...|....|| .:||  |.:|...||||..:|.||| .|..|
  Fly   635 IFALLISQTYIAKLAAFITSSKIAGDIGSLHDLVDQNK--VQFGTIRGGATSVYFSESN-DTDNR 696

  Fly   687 M--YEFMRDNPQYMTNTNQEGVDRVENS--NYAFLMESTTIEYITERRCTLTQVGALLDEKGYGI 747
            |  .:.:...|...|..|:||||||:.|  .||||||:|.::|..:|.|.|||:|....||.|||
  Fly   697 MAWNKMLSFKPDAFTKNNEEGVDRVKLSKGTYAFLMETTNLQYYVQRNCELTQIGESFGEKHYGI 761

  Fly   748 AMRKNWPYRDTLSQAVLEMQEQGLLTKMKTKWWQEKRGGGACSDADEDSGAVALEISNLGGVFLV 812
            |:..|..:|..||..:|.:.|:|.|.|::.||:.........:....|.|  ..::.::||:|:|
  Fly   762 AVPLNADFRSNLSVGILRLSERGELFKLRNKWFNSNESTCDSNVPTIDDG--QFDMDSVGGLFVV 824

  Fly   813 MGVGSFFGIFVSLLEMV-----LGVKERSDENQVSFKTELLDEIRFILQCSGNTKAVKYPKNSSR 872
            :.||...|:.:.:.|.:     :.|||:... .::.|.|....|||.|        .:.|.::.|
  Fly   825 LIVGVVVGLVIGVAEFLWHVQRISVKEKIPP-MLALKAEFYFVIRFWL--------TRKPLHTYR 880

  Fly   873 SNASSKSKGSSMSVDSLPEDTSEADASGK 901
            .:..|.|.|.|    ||.:.||.:.|..|
  Fly   881 QSRDSTSTGYS----SLEQITSASSAKKK 905

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Grik	NP_001262788.1	PBP1_iGluR_Kainate	37..391	CDD:107377	87/383 (23%)
		ANF_receptor	53..374	CDD:279440	80/347 (23%)
		Periplasmic_Binding_Protein_Type_2	411..781	CDD:304360	153/387 (40%)
		Lig_chan	543..816	CDD:278489	101/277 (36%)
GluRIIB	NP_523485.3	PBP1_iGluR_Kainate	26..393	CDD:107377	87/383 (23%)
		ANF_receptor	41..378	CDD:279440	81/351 (23%)
		PBP2_iGluR_Kainate	422..795	CDD:270432	151/378 (40%)
		Lig_chan	555..822	CDD:278489	99/271 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462594
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	137	1.000	Inparanoid score	I1813
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D17567at33392
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	7.000