DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Grik and GluRIIA

DIOPT Version :9

Sequence 1:	NP_001262788.1	Gene:	Grik / 42476	FlyBaseID:	FBgn0038840	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	NP_523484.2	Gene:	GluRIIA / 33788	FlyBaseID:	FBgn0004620	Length:	907	Species:	Drosophila melanogaster

Alignment Length:	930	Identity:	288/930 - (30%)
Similarity:	470/930 - (50%)	Gaps:	96/930 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 LGFILTSLLLAFPGCRGERTNVGLVYENTDPDLEKIFHLAISKANE-ENEDLQLHGVSVSIEPGN 78
            :||:  ..::|..|.......||.::...:.::|..|..|..:.|. :..:|:...:...:...:
  Fly    15 IGFL--EGIIALGGDDRNEITVGAIFYENEKEIELSFDQAFREVNNMKFSELRFVTIKRYMPTND 77

  Fly    79 SFETSKKLCKMLRQNLVAVFGPTSNLAARHAMSICDAKELPFLD-------TRWDFGAQLPTINL 136
            ||...:..|:::...:.|:|||:|..|:.....|.:|..:|.::       ||.:......:||:
  Fly    78 SFLLQQITCELISNGVAAIFGPSSKAASDIVAQIANATGIPHIEYDLKLEATRQEQLNHQMSINV 142

  Fly   137 HPHPATLGVALRDMVVA-LGWESFTIIYESGEYLPTVRELLQMYGTAGPTVTVRRYELDLNGNYR 200
            .|..:.|..|..:::.: ..|.:||:|||:.|.|..:::|:.:..              ||.:|.
  Fly   143 APSLSVLSRAYFEIIKSNYEWRTFTLIYETPEGLARLQDLMNIQA--------------LNSDYV 193

  Fly   201 NVLRRIRNADDFSFVVVGSMATL----------PEFFKQAQQVGLVTSDYR-------YIIGNLD 248
            .:......|||:..:...:..|.          |:..|:..:|.:   |::       :.:.:||
  Fly   194 KLRNLADYADDYRILWKETDETFHEQRIILDCEPKTLKELLKVSI---DFKLQGPFRNWFLTHLD 255

  Fly   249 WHTMDLEPYQHAG--TNITGLRLVSPDSEQVQEVAKALYESEEPFQN-VSCPLTNSMALVYDGVQ 310
            .|...|....:..  .|||.:||...|:...:.....|.:.::...| ...|:     |:||.|.
  Fly   256 THNSGLRDIYNEDFKANITSVRLKVVDANPFERKKTRLTKVDQILGNQTMLPI-----LIYDAVV 315

  Fly   311 LLAETYKHV-----NFRPVALSCNDDSAWDKGYTLVNYMKSLTLNGL-----TGPIRFDYEGLRT 365
            |.|.:.::|     .|.|....|...|.|..|..:||.||:::.:.:     |..::.|..|.|.
  Fly   316 LFASSARNVIAAMQPFHPPNRHCGSSSPWMLGAFIVNEMKTISEDDVEPHFKTENMKLDEYGQRI 380

  Fly   366 DFKLEVIELAVSGMQKIGQWSGEDGFQE---NRPAPAHSLEPDMRSLVNKSFVVITAISEPYGML 427
            .|.||:.:..|:....:  |:.::|.::   |....:.....|. |...|.:.|:|...|||.|:
  Fly   381 HFNLEIYKPTVNEPMMV--WTPDNGIKKRLLNLELESAGTTQDF-SEQRKVYTVVTHYEEPYFMM 442

  Fly   428 KETSEKLEGNDQFEGFGIELIDELSKKLGFSYTWRLQEDNKYGGIDPKTGEWNGMLREIIDSRAD 492
            ||..|...|.:::||:.::||.:||:.:.|.|.:.:...|  |..:|:|.:|:|::|::||..|.
  Fly   443 KEDHENFRGREKYEGYAVDLISKLSELMEFDYEFMIVNGN--GKYNPETKQWDGIIRKLIDHHAQ 505

  Fly   493 MGITDLTMTSERESGVDFTIPFMSLGIGILFRKPMKEPPKLFSFMSPFSGEVWLWLGLAYMGVSI 557
            :|:.|||:|..|.|.||||:|||.|||.||..|...||...|:|:.||:.|||:::..|.:.:::
  Fly   506 IGVCDLTITQMRRSVVDFTVPFMQLGISILHYKSPPEPKNQFAFLEPFAVEVWIYMIFAQLIMTL 570

  Fly   558 SMFVLGRLSPAEWDNPYPCIEEPTELENQFSFANCLWFSIGALLQQGSELAPKAYSTRAVAASWW 622
            :...:.|||..||..|.|.|::|.||||.::..|..|..:|:::|||.::.|:....|.:...||
  Fly   571 AFVFIARLSYREWLPPNPAIQDPDELENIWNVNNSTWLMVGSIMQQGCDILPRGPHMRILTGMWW 635

  Fly   623 FFTLILVSSYTANLAAFLTVESLVTPINDADDLSKNKGGVNYGAKIGGATFNFFKESNYPTYQRM 687
            ||.|:::|:||||||||||.....:.|....||.: :..|::|:..||:|..||.|||...|||.
  Fly   636 FFALMMLSTYTANLAAFLTSNKWQSSIKSLQDLIE-QDKVHFGSMRGGSTSLFFSESNDTDYQRA 699

  Fly   688 YEFMRD-NPQYMTNTNQEGVDRV--ENSNYAFLMESTTIEYITERRCTLTQVGALLDEKGYGIAM 749
            :..|:| ||...|:||:|||.||  |...||||||:|::.|..||.|.|||:|..:.||.||:|:
  Fly   700 WNQMKDFNPSAFTSTNKEGVARVRKEKGGYAFLMETTSLTYNIERNCDLTQIGEQIGEKHYGLAV 764

  Fly   750 RKNWPYRDTLSQAVLEMQEQGLLTKMKTKWWQEKRGGGACS-----DADEDSGAVALEISNLGGV 809
            .....||..||.::|::.|:|.|.|||.|||  |.....|.     |.||      |.|..||||
  Fly   765 PLGSDYRTNLSVSILQLSERGELQKMKNKWW--KNHNVTCDSYHEVDGDE------LSIIELGGV 821

  Fly   810 FLVMGVGSFFGIFVSLLEMVLGVKERSDENQV----SFKTELLDEIRFILQCSGNTKAVKYPKNS 870
            |||:..|...|:.:.:.|.:..|:..:.|.:|    :||.||:..::|.::......:....|:|
  Fly   822 FLVLAGGVLIGVILGIFEFLWNVQNVAVEERVTPWQAFKAELIFALKFWVRKKPMRISSSSDKSS 886

  Fly   871 SR----SNASSKSKGSSMSV 886
            ||    |..|||.|..|.:|
  Fly   887 SRRSSGSRRSSKEKSRSKTV 906

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Grik	NP_001262788.1	PBP1_iGluR_Kainate	37..391	CDD:107377	84/392 (21%)
		ANF_receptor	53..374	CDD:279440	79/359 (22%)
		Periplasmic_Binding_Protein_Type_2	411..781	CDD:304360	158/372 (42%)
		Lig_chan	543..816	CDD:278489	118/280 (42%)
GluRIIA	NP_523484.2	PBP1_iGluR_Kainate	33..404	CDD:107377	85/394 (22%)
		ANF_receptor	46..386	CDD:279440	80/361 (22%)
		PBP2_iGluR_Kainate	426..796	CDD:270432	159/374 (43%)
		Lig_chan	556..828	CDD:278489	118/280 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462597
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	137	1.000	Inparanoid score	I1813
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D17567at33392
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	P	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	8	7.900