Protein Alignment Grik and gria4b

DIOPT Version :10

• Sequence 1: NP_001262788.1
• Gene: Grik / 42476
• FlyBaseID: FBgn0038840
• Length: 907
• Species: Drosophila melanogaster
• Sequence 2: NP_997917.2
• Gene: gria4b / 336069
• ZFINID: ZDB-GENE-030131-8013
• Length: 904
• Species: Danio rerio
• Alignment Length: 887
• Identity: 297/887 - (33%)
• Similarity: 470/887 - (52%)
• Gaps: 46/887 - (5%)

  Fly    37 GLVYENTDPDLEKIFHLAI------SKANEENEDLQLHGVSVSIEPGNSFETSKKLCKMLRQNLV 95
            ||...|||.:. ..|.|||      ..|:|...:|..|  ..:||..|||..:...|....:.:.
Zfish    31 GLFIRNTDQEY-TAFRLAIFLHNTSPNASEAPFNLVPH--VDNIETANSFAVTNAFCSQYSRGVF 92

  Fly    96 AVFGPTSNLAARHAMSICDAKELPFLDTRWDFGAQLPTINLHPHPATLGVALRDMVVALGWESFT 160
            |:||.....:.....|.|.|..:..:...:....:...: |...|:..| ||..::....|..|.
Zfish    93 AIFGLYDKRSVHTLTSFCGALHISLITPSFPTEGESQFV-LQLRPSIRG-ALLSLLDHYDWNRFV 155

  Fly   161 IIYESGEYLPTVRELLQMYGTAGPTVTVRRYELDLNGNYRNVLRRIRNADDFSFVVVGSMATLPE 225
            .:|::......::.:::..|..|..|:....|...:.:||.:|..:....:.:||:......|..
Zfish   156 FLYDTDRGYSILQAIMEKAGQNGWQVSAICVENFNDASYRQLLEDLDRRQEKTFVIDLEAERLNN 220

  Fly   226 FFKQAQQVGLVTSDYRYIIGNLDWHTMDLEPYQHAGTNITGLRLVSPDSEQVQEVAK---ALYES 287
            ..:|...||.....|.||:.||.:..::||.:.|.|.|:||.:||...:..|.::.:   .|.:.
Zfish   221 MLEQIVSVGKHVKGYHYIMANLGFKDINLERFMHGGANVTGFQLVDFSNPMVIKLMQRWNKLDQR 285

  Fly   288 EEPFQNVSCPLTNSMALVYDGVQLLAETYKH-------VNFRPVALSC--NDDSAWDKGYTLVNY 343
            |.|  ....|...:.||.||||.::||.:::       ::.|.:|..|  |..:.|::|..:...
Zfish   286 EYP--GSDAPPKYTSALTYDGVMVMAEAFRNLRRQKVDISRRGIAGDCLANPAAPWNQGIDMERT 348

  Fly   344 MKSLTLNGLTGPIRFDYEGLRTDFKLEVIELAVSGMQKIGQWSGEDGFQENRPAPAHSLEPDMRS 408
            :|.:.|.||||.::||:.|.|.::.::|.||..:|.::||.|:..|.....:.   |:|.|:..|
Zfish   349 LKQVHLQGLTGNVQFDHYGRRVNYTMDVFELKSNGPRRIGYWNDADKLVLTQD---HALLPNETS 410

  Fly   409 -LVNKSFVVITAISEPYGMLKETSEKLEGNDQFEGFGIELIDELSKKLGFSYTWRLQEDNKYGGI 472
             :.|::.:|.|.:..||.|||:..|..|||:|:||:.::|..|::|.:||.|...:..|.|||..
Zfish   411 GMENRTVIVTTIMEGPYVMLKKNWEMYEGNEQYEGYCVDLASEIAKHIGFKYKISIVPDGKYGAR 475

  Fly   473 DPKTGEWNGMLREIIDSRADMGITDLTMTSERESGVDFTIPFMSLGIGILFRKPMKEPPKLFSFM 537
            ||:|..||||:.|::..:|::.:..||:|..||..:||:.|||||||.|:.:||.|..|.:|||:
Zfish   476 DPETKIWNGMVGELVYGKAEIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFL 540

  Fly   538 SPFSGEVWLWLGLAYMGVSISMFVLGRLSPAEWDNPYPCIEEPT------ELENQFSFANCLWFS 596
            .|.:.|:|:.:..||:|||:.:|::.|.||.||....|  ||.|      :..|:|...|.||||
Zfish   541 DPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEP--EEGTDGLPSDQPPNEFGIFNSLWFS 603

  Fly   597 IGALLQQGSELAPKAYSTRAVAASWWFFTLILVSSYTANLAAFLTVESLVTPINDADDLSKNKGG 661
            :||.:|||.:::|::.|.|.|...|||||||::||||||||||||||.:|:||..|:||:| :..
Zfish   604 LGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAK-QTD 667

  Fly   662 VNYGAKIGGATFNFFKESNYPTYQRMYEFMRD-NPQYMTNTNQEGVDRVENS--NYAFLMESTTI 723
            :.||....|:|..||:.|....|::|:.:|:. .|...|.|..|||.||..|  .||||:|||..
Zfish   668 IAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKSAEPTVFTKTTAEGVARVRKSKGKYAFLLESTMN 732

  Fly   724 EYITERR-CTLTQVGALLDEKGYGIAMRKNWPYRDTLSQAVLEMQEQGLLTKMKTKWWQEKRGGG 787
            ||..:|: |...:||..||.||||:|..|....|..::.|||::.|||||.|:|.|||.:|...|
Zfish   733 EYTEQRKPCDTMKVGGNLDSKGYGVATPKGSQLRSAVNLAVLKLNEQGLLDKLKNKWWYDKGECG 797

  Fly   788 ACSDADEDSGAVALEISNLGGVFLVMGVGSFFGIFVSLLEMVLGVKERSDENQVSFKTELLDEIR 852
            :....::|..:.||.:||:.|||.::..|....:.|:|:|.....:..:...:::|...:.::.|
Zfish   798 SGGGGEKDKSSQALSLSNVAGVFYILVGGLGLAMLVALIEFCYKSRNEAKRMKLTFTEAMRNKAR 862

  Fly   853 FILQCS----GNTKAVKYPKNSSRSNASSKSKGSSMSVDSLP 890
            ..:..|    |.......||......:..:|.|.::....||
Zfish   863 LSITGSVGENGRVLTPDCPKAVHSGPSLRQSSGLALVSSDLP 904

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Grik	NP_001262788.1	PBP1_iGluR_Kainate	35..395	CDD:380605	97/375 (26%)
		Periplasmic_Binding_Protein_Type_2	411..781	CDD:473866	171/379 (45%)
gria4b	NP_997917.2	Periplasmic_Binding_Protein_type1	28..400	CDD:471960	97/375 (26%)
		PBP2_iGluR_AMPA_GluR4	414..793	CDD:270445	172/381 (45%)
		Lig_chan	546..826	CDD:459656	125/282 (44%)