DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Grik and gria4b

DIOPT Version :9

Sequence 1:	NP_001262788.1	Gene:	Grik / 42476	FlyBaseID:	FBgn0038840	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	NP_997917.2	Gene:	gria4b / 336069	ZFINID:	ZDB-GENE-030131-8013	Length:	904	Species:	Danio rerio

Alignment Length:	887	Identity:	297/887 - (33%)
Similarity:	470/887 - (52%)	Gaps:	46/887 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 GLVYENTDPDLEKIFHLAI------SKANEENEDLQLHGVSVSIEPGNSFETSKKLCKMLRQNLV 95
            ||...|||.:. ..|.|||      ..|:|...:|..|  ..:||..|||..:...|....:.:.
Zfish    31 GLFIRNTDQEY-TAFRLAIFLHNTSPNASEAPFNLVPH--VDNIETANSFAVTNAFCSQYSRGVF 92

  Fly    96 AVFGPTSNLAARHAMSICDAKELPFLDTRWDFGAQLPTINLHPHPATLGVALRDMVVALGWESFT 160
            |:||.....:.....|.|.|..:..:...:....:...: |...|:..| ||..::....|..|.
Zfish    93 AIFGLYDKRSVHTLTSFCGALHISLITPSFPTEGESQFV-LQLRPSIRG-ALLSLLDHYDWNRFV 155

  Fly   161 IIYESGEYLPTVRELLQMYGTAGPTVTVRRYELDLNGNYRNVLRRIRNADDFSFVVVGSMATLPE 225
            .:|::......::.:::..|..|..|:....|...:.:||.:|..:....:.:||:......|..
Zfish   156 FLYDTDRGYSILQAIMEKAGQNGWQVSAICVENFNDASYRQLLEDLDRRQEKTFVIDLEAERLNN 220

  Fly   226 FFKQAQQVGLVTSDYRYIIGNLDWHTMDLEPYQHAGTNITGLRLVSPDSEQVQEVAK---ALYES 287
            ..:|...||.....|.||:.||.:..::||.:.|.|.|:||.:||...:..|.::.:   .|.:.
Zfish   221 MLEQIVSVGKHVKGYHYIMANLGFKDINLERFMHGGANVTGFQLVDFSNPMVIKLMQRWNKLDQR 285

  Fly   288 EEPFQNVSCPLTNSMALVYDGVQLLAETYKH-------VNFRPVALSC--NDDSAWDKGYTLVNY 343
            |.|  ....|...:.||.||||.::||.:::       ::.|.:|..|  |..:.|::|..:...
Zfish   286 EYP--GSDAPPKYTSALTYDGVMVMAEAFRNLRRQKVDISRRGIAGDCLANPAAPWNQGIDMERT 348

  Fly   344 MKSLTLNGLTGPIRFDYEGLRTDFKLEVIELAVSGMQKIGQWSGEDGFQENRPAPAHSLEPDMRS 408
            :|.:.|.||||.::||:.|.|.::.::|.||..:|.::||.|:..|.....:.   |:|.|:..|
Zfish   349 LKQVHLQGLTGNVQFDHYGRRVNYTMDVFELKSNGPRRIGYWNDADKLVLTQD---HALLPNETS 410

  Fly   409 -LVNKSFVVITAISEPYGMLKETSEKLEGNDQFEGFGIELIDELSKKLGFSYTWRLQEDNKYGGI 472
             :.|::.:|.|.:..||.|||:..|..|||:|:||:.::|..|::|.:||.|...:..|.|||..
Zfish   411 GMENRTVIVTTIMEGPYVMLKKNWEMYEGNEQYEGYCVDLASEIAKHIGFKYKISIVPDGKYGAR 475

  Fly   473 DPKTGEWNGMLREIIDSRADMGITDLTMTSERESGVDFTIPFMSLGIGILFRKPMKEPPKLFSFM 537
            ||:|..||||:.|::..:|::.:..||:|..||..:||:.|||||||.|:.:||.|..|.:|||:
Zfish   476 DPETKIWNGMVGELVYGKAEIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFL 540

  Fly   538 SPFSGEVWLWLGLAYMGVSISMFVLGRLSPAEWDNPYPCIEEPT------ELENQFSFANCLWFS 596
            .|.:.|:|:.:..||:|||:.:|::.|.||.||....|  ||.|      :..|:|...|.||||
Zfish   541 DPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEP--EEGTDGLPSDQPPNEFGIFNSLWFS 603

  Fly   597 IGALLQQGSELAPKAYSTRAVAASWWFFTLILVSSYTANLAAFLTVESLVTPINDADDLSKNKGG 661
            :||.:|||.:::|::.|.|.|...|||||||::||||||||||||||.:|:||..|:||:| :..
Zfish   604 LGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAK-QTD 667

  Fly   662 VNYGAKIGGATFNFFKESNYPTYQRMYEFMRD-NPQYMTNTNQEGVDRVENS--NYAFLMESTTI 723
            :.||....|:|..||:.|....|::|:.:|:. .|...|.|..|||.||..|  .||||:|||..
Zfish   668 IAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKSAEPTVFTKTTAEGVARVRKSKGKYAFLLESTMN 732

  Fly   724 EYITERR-CTLTQVGALLDEKGYGIAMRKNWPYRDTLSQAVLEMQEQGLLTKMKTKWWQEKRGGG 787
            ||..:|: |...:||..||.||||:|..|....|..::.|||::.|||||.|:|.|||.:|...|
Zfish   733 EYTEQRKPCDTMKVGGNLDSKGYGVATPKGSQLRSAVNLAVLKLNEQGLLDKLKNKWWYDKGECG 797

  Fly   788 ACSDADEDSGAVALEISNLGGVFLVMGVGSFFGIFVSLLEMVLGVKERSDENQVSFKTELLDEIR 852
            :....::|..:.||.:||:.|||.::..|....:.|:|:|.....:..:...:::|...:.::.|
Zfish   798 SGGGGEKDKSSQALSLSNVAGVFYILVGGLGLAMLVALIEFCYKSRNEAKRMKLTFTEAMRNKAR 862

  Fly   853 FILQCS----GNTKAVKYPKNSSRSNASSKSKGSSMSVDSLP 890
            ..:..|    |.......||......:..:|.|.::....||
Zfish   863 LSITGSVGENGRVLTPDCPKAVHSGPSLRQSSGLALVSSDLP 904

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Grik	NP_001262788.1	PBP1_iGluR_Kainate	37..391	CDD:107377	97/371 (26%)
		ANF_receptor	53..374	CDD:279440	84/338 (25%)
		Periplasmic_Binding_Protein_Type_2	411..781	CDD:304360	171/379 (45%)
		Lig_chan	543..816	CDD:278489	125/282 (44%)
gria4b	NP_997917.2	Periplasmic_Binding_Protein_Type_1	28..398	CDD:324556	97/373 (26%)
		PBP2_iGluR_AMPA_GluR4	414..793	CDD:270445	172/381 (45%)
		Lig_chan	546..827	CDD:306551	125/283 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591299
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.850