DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Grik and GluRIIE

DIOPT Version :9

Sequence 1:	NP_001262788.1	Gene:	Grik / 42476	FlyBaseID:	FBgn0038840	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	NP_001036733.1	Gene:	GluRIIE / 318623	FlyBaseID:	FBgn0051201	Length:	897	Species:	Drosophila melanogaster

Alignment Length:	872	Identity:	423/872 - (48%)
Similarity:	587/872 - (67%)	Gaps:	22/872 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 ERTNVGLVYENTDPDLEKIFHLAISKANEENEDLQLHGVSVSIEPGNSFETSKKLCKMLRQNLVA 96
            |...:||:.:.....:..:|..||..||:| ....|..:...:..|:::::..|||:||...:..
  Fly    37 ESVPIGLLTDQNTEQMNIVFDHAIDVANQE-VGTSLTSLKEEVNYGDAYQSYGKLCRMLETGIAG 100

  Fly    97 VFGPTSNLAARHAMSICDAKELPFLDTRWDFGAQLPTINLHPHPATLGVALRDMVVALGWESFTI 161
            ||||:|...|.|.||||||.::|.:.:.....|:  ..|||||||.|..||..::....|..|..
  Fly   101 VFGPSSRHTAVHLMSICDAMDIPHIYSYMSENAE--GFNLHPHPADLAKALYSLITEFNWTRFIF 163

  Fly   162 IYESGEYLPTVRELLQMYGTAGPTVTVRRYELDLNGNYRNVLRRIRNADDFSFVVVGSMATLPEF 226
            :|||.|||..:.||..|.|.:|..:||.||::.|||||:.||||:|.:.|...|||||..|:|||
  Fly   164 LYESAEYLNILNELTTMLGKSGTVITVLRYDMQLNGNYKQVLRRVRKSVDNRIVVVGSSETMPEF 228

  Fly   227 FKQAQQVGLVTSDYRYIIGNLDWHTMDLEPYQHAGTNITGLRLVSPDSEQVQEVAKAL-YES-EE 289
            ..||||||::..||:|||||||:|:.|||.|:::..|||||||.||:...|:|:...| |.: ::
  Fly   229 LNQAQQVGIINEDYKYIIGNLDFHSFDLEEYKYSEANITGLRLFSPEKMAVKELLMKLGYPTDQD 293

  Fly   290 PFQNVSCPLTNSMALVYDGVQLLAETYKHVNFRPVALSCND--DSAWDKGYTLVNYMKSLTLNG- 351
            .|:|.|||:|..|||.||.|||.|:|.|::.|:|:..:|:.  :|..|.|.:..|||::|.|..
  Fly   294 EFRNGSCPITVEMALTYDAVQLFAQTLKNLPFKPMPQNCSQRTESVRDDGSSFKNYMRTLRLTDR 358

  Fly   352 -LTGPIRFDYEG-LRTDFKLEVIELAVSGMQKIGQWSGEDGFQENRPAPAHS-LEPDMRSLVNKS 413
             |||||.|  || :|..:.|:||||..||:.|:|.|..:..::..|.||..: .:....||.||:
  Fly   359 LLTGPIYF--EGNVRKGYHLDVIELQPSGIVKVGTWDEDRQYRPQRLAPTTAQFDSVDNSLANKT 421

  Fly   414 FVVITAI-SEPYGMLKETSEKLEGNDQFEGFGIELIDELSKKLGFSYTWRLQEDNKYGGIDPKTG 477
            |:::.:: ::||..|.||.::||||.|:||:|::||.||:.||||::|: :...|.||..:..|.
  Fly   422 FIILLSVPNKPYAQLVETYKQLEGNSQYEGYGVDLIKELADKLGFNFTF-VNGGNDYGSYNKSTN 485

  Fly   478 EWNGMLREIIDSRADMGITDLTMTSERESGVDFTIPFMSLGIGILFRKPMKEPPKLFSFMSPFSG 542
            |..||||||:..|||:.|||||:|||||..:|||||||:|||.||:.||.|..|:||:||.|||.
  Fly   486 ESTGMLREIMTGRADLAITDLTITSEREQALDFTIPFMNLGIAILYLKPQKATPELFTFMDPFSE 550

  Fly   543 EVWLWLGLAYMGVSISMFVLGRLSPAEWDNPYPCIEEPTELENQFSFANCLWFSIGALLQQGSEL 607
            |||.:||.:::|||:|.|:||||||:||||||||||||.||||||:..|.:||:.|||||||||:
  Fly   551 EVWWFLGFSFLGVSLSFFILGRLSPSEWDNPYPCIEEPEELENQFTLGNSIWFTTGALLQQGSEI 615

  Fly   608 APKAYSTRAVAASWWFFTLILVSSYTANLAAFLTVESLVTPINDADDLSKNKGGVNYGAKIGGAT 672
            .|||.|||.||:.|||||||:|||||||||||||:|...:.||..|||:.||.||.||||..|:|
  Fly   616 GPKALSTRTVASFWWFFTLIVVSSYTANLAAFLTIEKPQSLINSVDDLADNKDGVVYGAKKTGST 680

  Fly   673 FNFFKESNYPTYQRMYEFMRDNPQYMTNTNQEGVDRVE-NSNYAFLMESTTIEYITERRCTLTQV 736
            .|||..|....|::|.:||.:||||:|..|.|||:||: |::||||||||:|||.|:|.|.|.::
  Fly   681 RNFFMTSAEERYKKMNKFMSENPQYLTEDNMEGVNRVKTNTHYAFLMESTSIEYNTKRECNLKKI 745

  Fly   737 GALLDEKGYGIAMRKNWPYRDTLSQAVLEMQEQGLLTKMKTKWWQEKRGGGACSDADEDSGAVAL 801
            |..||||||||||||:||:|...:.|:||:||||:|.|||.|||.|. |.|.|:..::...|..|
  Fly   746 GDALDEKGYGIAMRKDWPHRGKFNNALLELQEQGVLEKMKNKWWNEV-GTGICATKEDAPDATPL 809

  Fly   802 EISNLGGVFLVMGVGSFFGIFVSLLEMVLGVKERSDENQVSFKTELLDEIRFILQCSGNTKAVKY 866
            :::||.|||.|:.|||...:...::..||.|.:::...:|..:..|.:|.:|::..:...:.:
  Fly   810 DMNNLEGVFFVLLVGSCCALLYGIISWVLFVMKKAHHYRVPLRDALKEEFQFVIDFNNYVRVL-- 872

  Fly   867 PKNSSRSNASSKSKGSSMSVDSLPEDT 893
             |||  ::..|:|:.|||||.|:.:::
  Fly   873 -KNS--ASIYSRSRQSSMSVASVAQES 896

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Grik	NP_001262788.1	PBP1_iGluR_Kainate	37..391	CDD:107377	157/360 (44%)
		ANF_receptor	53..374	CDD:279440	147/327 (45%)
		Periplasmic_Binding_Protein_Type_2	411..781	CDD:304360	226/371 (61%)
		Lig_chan	543..816	CDD:278489	167/273 (61%)
GluRIIE	NP_001036733.1	PBP1_iGluR_Kainate	42..396	CDD:107377	157/358 (44%)
		ANF_receptor	51..382	CDD:279440	149/335 (44%)
		PBP2_iGluR_Kainate	419..790	CDD:270432	226/371 (61%)
		Lig_chan	551..824	CDD:278489	167/273 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45447136
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	137	1.000	Inparanoid score	I1813
Isobase	1	0.950	-	0	Normalized mean entropy	S3952
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D17567at33392
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm1027
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	P	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	10	9.850