Protein Alignment Grik and GluRIIE

DIOPT Version :10

• Sequence 1: NP_001262788.1
• Gene: Grik / 42476
• FlyBaseID: FBgn0038840
• Length: 907
• Species: Drosophila melanogaster
• Sequence 2: NP_001036733.1
• Gene: GluRIIE / 318623
• FlyBaseID: FBgn0051201
• Length: 897
• Species: Drosophila melanogaster
• Alignment Length: 872
• Identity: 423/872 - (48%)
• Similarity: 587/872 - (67%)
• Gaps: 22/872 - (2%)

  Fly    32 ERTNVGLVYENTDPDLEKIFHLAISKANEENEDLQLHGVSVSIEPGNSFETSKKLCKMLRQNLVA 96
            |...:||:.:.....:..:|..||..||:| ....|..:...:..|:::::..|||:||...:..
  Fly    37 ESVPIGLLTDQNTEQMNIVFDHAIDVANQE-VGTSLTSLKEEVNYGDAYQSYGKLCRMLETGIAG 100

  Fly    97 VFGPTSNLAARHAMSICDAKELPFLDTRWDFGAQLPTINLHPHPATLGVALRDMVVALGWESFTI 161
            ||||:|...|.|.||||||.::|.:.:.....|:  ..|||||||.|..||..::....|..|..
  Fly   101 VFGPSSRHTAVHLMSICDAMDIPHIYSYMSENAE--GFNLHPHPADLAKALYSLITEFNWTRFIF 163

  Fly   162 IYESGEYLPTVRELLQMYGTAGPTVTVRRYELDLNGNYRNVLRRIRNADDFSFVVVGSMATLPEF 226
            :|||.|||..:.||..|.|.:|..:||.||::.|||||:.||||:|.:.|...|||||..|:|||
  Fly   164 LYESAEYLNILNELTTMLGKSGTVITVLRYDMQLNGNYKQVLRRVRKSVDNRIVVVGSSETMPEF 228

  Fly   227 FKQAQQVGLVTSDYRYIIGNLDWHTMDLEPYQHAGTNITGLRLVSPDSEQVQEVAKAL-YES-EE 289
            ..||||||::..||:|||||||:|:.|||.|:::..|||||||.||:...|:|:...| |.: ::
  Fly   229 LNQAQQVGIINEDYKYIIGNLDFHSFDLEEYKYSEANITGLRLFSPEKMAVKELLMKLGYPTDQD 293

  Fly   290 PFQNVSCPLTNSMALVYDGVQLLAETYKHVNFRPVALSCND--DSAWDKGYTLVNYMKSLTLNG- 351
            .|:|.|||:|..|||.||.|||.|:|.|::.|:|:..:|:.  :|..|.|.:..|||::|.|..
  Fly   294 EFRNGSCPITVEMALTYDAVQLFAQTLKNLPFKPMPQNCSQRTESVRDDGSSFKNYMRTLRLTDR 358

  Fly   352 -LTGPIRFDYEG-LRTDFKLEVIELAVSGMQKIGQWSGEDGFQENRPAPAHS-LEPDMRSLVNKS 413
             |||||.|  || :|..:.|:||||..||:.|:|.|..:..::..|.||..: .:....||.||:
  Fly   359 LLTGPIYF--EGNVRKGYHLDVIELQPSGIVKVGTWDEDRQYRPQRLAPTTAQFDSVDNSLANKT 421

  Fly   414 FVVITAI-SEPYGMLKETSEKLEGNDQFEGFGIELIDELSKKLGFSYTWRLQEDNKYGGIDPKTG 477
            |:::.:: ::||..|.||.::||||.|:||:|::||.||:.||||::|: :...|.||..:..|.
  Fly   422 FIILLSVPNKPYAQLVETYKQLEGNSQYEGYGVDLIKELADKLGFNFTF-VNGGNDYGSYNKSTN 485

  Fly   478 EWNGMLREIIDSRADMGITDLTMTSERESGVDFTIPFMSLGIGILFRKPMKEPPKLFSFMSPFSG 542
            |..||||||:..|||:.|||||:|||||..:|||||||:|||.||:.||.|..|:||:||.|||.
  Fly   486 ESTGMLREIMTGRADLAITDLTITSEREQALDFTIPFMNLGIAILYLKPQKATPELFTFMDPFSE 550

  Fly   543 EVWLWLGLAYMGVSISMFVLGRLSPAEWDNPYPCIEEPTELENQFSFANCLWFSIGALLQQGSEL 607
            |||.:||.:::|||:|.|:||||||:||||||||||||.||||||:..|.:||:.|||||||||:
  Fly   551 EVWWFLGFSFLGVSLSFFILGRLSPSEWDNPYPCIEEPEELENQFTLGNSIWFTTGALLQQGSEI 615

  Fly   608 APKAYSTRAVAASWWFFTLILVSSYTANLAAFLTVESLVTPINDADDLSKNKGGVNYGAKIGGAT 672
            .|||.|||.||:.|||||||:|||||||||||||:|...:.||..|||:.||.||.||||..|:|
  Fly   616 GPKALSTRTVASFWWFFTLIVVSSYTANLAAFLTIEKPQSLINSVDDLADNKDGVVYGAKKTGST 680

  Fly   673 FNFFKESNYPTYQRMYEFMRDNPQYMTNTNQEGVDRVE-NSNYAFLMESTTIEYITERRCTLTQV 736
            .|||..|....|::|.:||.:||||:|..|.|||:||: |::||||||||:|||.|:|.|.|.::
  Fly   681 RNFFMTSAEERYKKMNKFMSENPQYLTEDNMEGVNRVKTNTHYAFLMESTSIEYNTKRECNLKKI 745

  Fly   737 GALLDEKGYGIAMRKNWPYRDTLSQAVLEMQEQGLLTKMKTKWWQEKRGGGACSDADEDSGAVAL 801
            |..||||||||||||:||:|...:.|:||:||||:|.|||.|||.|. |.|.|:..::...|..|
  Fly   746 GDALDEKGYGIAMRKDWPHRGKFNNALLELQEQGVLEKMKNKWWNEV-GTGICATKEDAPDATPL 809

  Fly   802 EISNLGGVFLVMGVGSFFGIFVSLLEMVLGVKERSDENQVSFKTELLDEIRFILQCSGNTKAVKY 866
            :::||.|||.|:.|||...:...::..||.|.:::...:|..:..|.:|.:|::..:...:.:
  Fly   810 DMNNLEGVFFVLLVGSCCALLYGIISWVLFVMKKAHHYRVPLRDALKEEFQFVIDFNNYVRVL-- 872

  Fly   867 PKNSSRSNASSKSKGSSMSVDSLPEDT 893
             |||  ::..|:|:.|||||.|:.:::
  Fly   873 -KNS--ASIYSRSRQSSMSVASVAQES 896

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Grik	NP_001262788.1	PBP1_iGluR_Kainate	35..395	CDD:380605	157/366 (43%)
		Periplasmic_Binding_Protein_Type_2	411..781	CDD:473866	226/371 (61%)
GluRIIE	NP_001036733.1	PBP1_iGluR_Kainate	40..402	CDD:380605	157/366 (43%)
		PBP2_iGluR_Kainate	419..790	CDD:270432	226/371 (61%)
		Lig_chan	551..824	CDD:459656	167/273 (61%)