Protein Alignment Grik and Nmdar2

DIOPT Version :10

• Sequence 1: NP_001262788.1
• Gene: Grik / 42476
• FlyBaseID: FBgn0038840
• Length: 907
• Species: Drosophila melanogaster
• Sequence 2: NP_001014714.1
• Gene: Nmdar2 / 31107
• FlyBaseID: FBgn0053513
• Length: 1083
• Species: Drosophila melanogaster
• Alignment Length: 981
• Identity: 226/981 - (23%)
• Similarity: 379/981 - (38%)
• Gaps: 239/981 - (24%)

  Fly     5 KMISTEASFPLGF----ILTSLLLAFPGCRG------------------ERTNVGLVYENTD--- 44
            |.|.|..|.|:..    :||.|:|....|:|                  |:.|:||:..:|:
  Fly    50 KRILTPPSGPISLLLLTVLTLLILDTRSCQGLRLTNGGGSLSKGAAANKEQLNIGLIAPHTNFGK 114

  Fly    45 PDLEKIFHLAISKANEEN------------EDLQLHGVSVSIEPGNSFETSKKLCK-MLRQNLVA 96
            .:..:..:.|::...:..            |...:|...:|:.|..:...| .||| .||.|:.|
  Fly   115 REYLRSINNAVTGLTKTRGAKLTFLKDYSFEQKNIHFDMMSLTPSPTAILS-TLCKEFLRVNVSA 178

  Fly    97 V--------FGPTSNLAARHAMSICDAKELPFLDTRWDFG-----AQLPTINLHPHPAT--LGVA 146
            :        || .|..:|::.:.:.....:|.:....|..     |...|:.|...|:.  ...|
  Fly   179 ILYMMNNEQFG-HSTASAQYFLQLAGYLGIPVISWNADNSGLERRASQSTLQLQLAPSIEHQSAA 242

  Fly   147 LRDMVVALGWESFTIIYESGEYLPTVRELLQMYGTAGPTVTVRRYELDLNGNYRNVLRRIRNADD 211
            :..::....|..|::                                        |..:|...||
  Fly   243 MLSILERYKWHQFSV----------------------------------------VTSQIAGHDD 267

  Fly   212 FSFVVVGSMATLPEFFKQAQQVGLV---TSDYRYIIGNLDWHTMDLEPYQHAGTNI--------- 264
            |...|...:|.:.|.||......:|   |||...:: |.:...|.|...|.....|
  Fly   268 FVQAVRERVAEMQEHFKFTILNSIVVTRTSDLMELV-NSEARVMLLYATQTEAITILRAAEEMKL 331

  Fly   265 TGLRLVSPDSEQVQEVAKALYESEEP-------FQNVSCPLTNSMA---LVYD-GVQ--LLAETY 316
            ||...|...|:.|.|...|  .|:.|       |...|..|.|.::   .:|. ||:  |.....
  Fly   332 TGENYVWVVSQSVIEKKDA--HSQFPVGMLGVHFDTSSAALMNEISNAIKIYSYGVEAYLTDPAN 394

  Fly   317 KHVNFRPVALSCNDD--SAWDKGYTLVNYMKSLTLNG-LTGP-IRFDYEGLRTDFKLEVIELAVS 377
            :.......:|||.|:  ..||.|.....|::::::.| |..| |.|..:|.....:|:::.|..|
  Fly   395 RDRRLTTQSLSCEDEGRGRWDNGEIFFKYLRNVSIEGDLNKPNIEFTADGDLRSAELKIMNLRPS 459

  Fly   378 GMQK------IGQW-SGEDGFQENRPA--PAHSLEPDMRSLVNKSFVVITAISE-PY-------- 424
            ...|      ||.| |.|....:.|..  |.:|..|. :.:..|..:.||.:.| ||
  Fly   460 ANNKNLVWEEIGVWKSWETQKLDIRDIAWPGNSHAPP-QGVPEKFHLKITFLEEAPYINLSPADP 523

  Fly   425 ---------GMLKETSEKLE-----------GNDQF----EGFGIELIDELSKKLGFSYTWRLQE 465
                     |:|...:...|           .|:.|    .||.|:|:::.:::|||:|.....|
  Fly   524 VSGKCLMDRGVLCRVAADHEMAADIDVGQAHRNESFYQCCSGFCIDLLEKFAEELGFTYELVRVE 588

  Fly   466 DNKYGGIDPKTGEWNGMLREIIDSRADMGITDLTMTSERESGVDFTIPFMSLGIGILF--RKPMK 528
            |.|:|.::  .|:|||::.::::.:.||.:|.|.:.:|||:.|||:.|||..||.|:.  |..:.
  Fly   589 DGKWGTLE--NGKWNGLIADLVNRKTDMVLTSLMINTEREAVVDFSEPFMETGIAIVVAKRTGII 651

  Fly   529 EPPKLFSFMSPFSGEVWLWLGL-AYMGVSISMFVLGRLSPAEWD----------NPYPCIEEPTE 582
            .|.   :|:.||....|:.:|: |....:..:|:...|||:.:|          .||
  Fly   652 SPT---AFLEPFDTASWMLVGIVAIQAATFMIFLFEWLSPSGYDMKLYLQNTNVTPY-------- 705

  Fly   583 LENQFSFANCLWFSIGALLQQGSEL-APKAYSTRAVAASWWFFTLILVSSYTANLAAFLTVES-- 644
               :||.....|.....|.|....: :|:.:::|.:...|..|.::.::.||||||||:....
  Fly   706 ---RFSLFRTYWLVWAVLFQAAVHVDSPRGFTSRFMTNVWALFAVVFLAIYTANLAAFMITREEF 767

  Fly   645 ----------LVTPINDADDLSKNKGGVNYGAKIGGATFNFFKESNYPTYQRMYEFMRDNPQYMT 699
                      ||.|.:.....           |.|...::....:.:..:..|:.:||   ||..
  Fly   768 HEFSGLNDSRLVHPFSHKPSF-----------KFGTIPYSHTDSTIHKYFNVMHNYMR---QYNK 818

  Fly   700 NTNQEGVDRVENSNY-AFLMESTTIEYIT--ERRCTLTQVGALLDEKGYGIAMRKNWPYRDTLSQ 761
            .:..:||..|.|.|. :|:.:.|.::|:.  :..|.|..||:.....|||:|..:|..|....::
  Fly   819 TSVADGVAAVLNGNLDSFIYDGTVLDYLVAQDEDCRLMTVGSWYAMTGYGLAFSRNSKYVQMFNK 883

  Fly   762 AVLEMQEQGLLTKMKTKWWQEKRGGGACSDADED---SGAVALEISNLGGVFLVMGVGSFFGIFV 823
            .:||.:..|.|.:::..|..     |.|....::   |..:|||  .....||::..|......:
  Fly   884 RLLEFRANGDLERLRRYWMT-----GTCRPGKQEHKSSDPLALE--QFLSAFLLLMAGILLAALL 941

  Fly   824 SLLEMV 829
            .|||.|
  Fly   942 LLLEHV 947

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Grik	NP_001262788.1	PBP1_iGluR_Kainate	35..395	CDD:380605	89/426 (21%)
		Periplasmic_Binding_Protein_Type_2	411..781	CDD:473866	108/431 (25%)
Nmdar2	NP_001014714.1	PBP1_iGluR_NMDA_NR2	99..485	CDD:380601	90/430 (21%)
		PBP2_iGluR_NMDA_Nr2	502..908	CDD:270436	110/440 (25%)