Protein Alignment Grik and Grik3

DIOPT Version :10

• Sequence 1: NP_001262788.1
• Gene: Grik / 42476
• FlyBaseID: FBgn0038840
• Length: 907
• Species: Drosophila melanogaster
• Sequence 2: NP_001106187.1
• Gene: Grik3 / 298521
• RGDID: 71027
• Length: 919
• Species: Rattus norvegicus
• Alignment Length: 889
• Identity: 340/889 - (38%)
• Similarity: 513/889 - (57%)
• Gaps: 45/889 - (5%)

  Fly    16 GFILTSLLLAFPGCRG--ERTNVGLVYENTD-PDL------EKIFHLAISKANEENEDLQLHGVS 71
            ||::.:..:  |..||  ....:|.::|..| |:.      |..|..:.:..|.....|....::
  Rat    18 GFLVCAFWI--PDSRGMPHVIRIGGIFEYADGPNAQVMNAEEHAFRFSANIINRNRTLLPNTTLT 80

  Fly    72 VSIEP---GNSFETSKKLCKMLRQNLVAVFGPTSNLAARHAMSICDAKELPFLDTRWDF----GA 129
            ..|:.   .:|||.:||.|..|...:||:|||:.........|||:|.|:|.:..||..    ..
  Rat    81 YDIQRIHFHDSFEATKKACDQLALGVVAIFGPSQGSCTNAVQSICNALEVPHIQLRWKHHPLDNK 145

  Fly   130 QLPTINLHPHPATLGVALRDMVVALGWESFTIIYESGEYLPTVRELLQMYGTAGPTVTVRRYELD 194
            ....:||:|..|:|..|:.|:|.:|.|.|.|::|:....|..::||:.........:.:|:..:|
  Rat   146 DTFYVNLYPDYASLSHAILDLVQSLKWRSATVVYDDSTGLIRLQELIMAPSRYNIRLKIRQLPID 210

  Fly   195 LNGNYRNVLRRIRNADDFSFVVVGSMATLPEFFKQAQQVGLVTSDYRYIIGNLDWHTMDLEPYQH 259
             :.:.|.:|:.::...:|..:...|.....:..|||..:|::|..|.:|...||.:.:|||||::
  Rat   211 -SDDSRPLLKEMKRGREFRIIFDCSHTMAAQILKQAMAMGMMTEYYHFIFTTLDLYALDLEPYRY 274

  Fly   260 AGTNITGLRLVSPDSEQVQEVAKALYESEEPFQNVSCPLTNS----------MALVYDGVQLLAE 314
            :|.|:||.|:::.|:..|..:.:..  |.|..|  :.|...|          .||:||.|.:::.
  Rat   275 SGVNLTGFRILNVDNPHVSAIVEKW--SMERLQ--AAPRAESGLLDGVMMTDAALLYDAVHIVSV 335

  Fly   315 TYKHVNFRPV-ALSCNDDSAWDKGYTLVNYMKSLTLNGLTGPIRFD-YEGLRTDFKLEVIELAVS 377
            .|:......| :|.|:...||..|...:|::|.....||||.|.|: ..||||||.|::|.|...
  Rat   336 CYQRAPQMTVNSLQCHRHKAWRFGGRFMNFIKEAQWEGLTGRIVFNKTSGLRTDFDLDIISLKED 400

  Fly   378 GMQKIGQWSGEDGFQENRPAPAHSLEPDMR-SLVNKSFVVITAISEPYGMLKETSEKLEGNDQFE 441
            |::|:|.||..||.  |....|....|::. ||.|:|.:|.|.:.||:.|.:::...|.|||:||
  Rat   401 GLEKVGVWSPADGL--NITEVAKGRGPNVTDSLTNRSLIVTTLLEEPFVMFRKSDRTLYGNDRFE 463

  Fly   442 GFGIELIDELSKKLGFSYTWRLQEDNKYGGIDPKTGEWNGMLREIIDSRADMGITDLTMTSERES 506
            |:.|:|:.||:..|||||..||.||.|||..|.| |:||||::|:||.:||:.:..||:|..||.
  Rat   464 GYCIDLLKELAHILGFSYEIRLVEDGKYGAQDDK-GQWNGMVKELIDHKADLAVAPLTITHVREK 527

  Fly   507 GVDFTIPFMSLGIGILFRKPMKEPPKLFSFMSPFSGEVWLWLGLAYMGVSISMFVLGRLSPAEWD 571
            .:||:.|||:||:.||:|||....|.:|||::|.|.::|:::.|||:|||..:||:.|.||.||.
  Rat   528 AIDFSKPFMTLGVSILYRKPNGTNPSVFSFLNPLSPDIWMYVLLAYLGVSCVLFVIARFSPYEWY 592

  Fly   572 NPYPCIEEPTELENQFSFANCLWFSIGALLQQGSELAPKAYSTRAVAASWWFFTLILVSSYTANL 636
            :.:||......:||.|:..|..||.:|:|:||||||.|||.|||.:...|||||||::|||||||
  Rat   593 DAHPCNPGSEVVENNFTLLNSFWFGMGSLMQQGSELMPKALSTRIIGGIWWFFTLIIISSYTANL 657

  Fly   637 AAFLTVESLVTPINDADDLSKNKGGVNYGAKIGGATFNFFKESNYPTYQRMYEFMRDNPQYMTNT 701
            |||||||.:.:||:.||||:| :..:.|||...|||..|||:|...|:::|:.||...|..:...
  Rat   658 AAFLTVERMESPIDSADDLAK-QTKIEYGAVKDGATMTFFKKSKISTFEKMWAFMSSKPSALVKN 721

  Fly   702 NQEGVDRVENSNYAFLMESTTIEYITERRCTLTQVGALLDEKGYGIAMRKNWPYRDTLSQAVLEM 766
            |:||:.|...::||.|||||||||||:|.|.|||:|.|:|.|||||......||||.::.|:|::
  Rat   722 NEEGIQRTLTADYALLMESTTIEYITQRNCNLTQIGGLIDSKGYGIGTPMGSPYRDKITIAILQL 786

  Fly   767 QEQGLLTKMKTKWWQEKRGGGACSDADEDSGAVALEISNLGGVFLVMGVGSFFGIFVSLLEMVLG 831
            ||:..|..||.|||   ||.| |.: :|:..|.||.|..:||:|:|:..|....:.|::.|.:..
  Rat   787 QEEDKLHIMKEKWW---RGSG-CPE-EENKEASALGIQKIGGIFIVLAAGLVLSVLVAVGEFIYK 846

  Fly   832 VKERSDENQVSFKTELLDEIRFILQCSGNTKAVKYPKNSSRSNA 875
            :::.::..|.||.:.:.|||||.|.|....|....|....:::|
  Rat   847 LRKTAEREQRSFCSTVADEIRFSLTCQRRLKHKPQPPMMVKTDA 890

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Grik	NP_001262788.1	PBP1_iGluR_Kainate	35..395	CDD:380605	113/385 (29%)
		Periplasmic_Binding_Protein_Type_2	411..781	CDD:473866	187/369 (51%)
Grik3	NP_001106187.1	PBP1_iGluR_Kainate	37..417	CDD:380605	114/386 (30%)
		PBP2_iGluR_Kainate_GluR7	433..801	CDD:270441	188/372 (51%)