DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Grik and Grik3

DIOPT Version :9

Sequence 1:	NP_001262788.1	Gene:	Grik / 42476	FlyBaseID:	FBgn0038840	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	NP_001106187.1	Gene:	Grik3 / 298521	RGDID:	71027	Length:	919	Species:	Rattus norvegicus

Alignment Length:	889	Identity:	340/889 - (38%)
Similarity:	513/889 - (57%)	Gaps:	45/889 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 GFILTSLLLAFPGCRG--ERTNVGLVYENTD-PDL------EKIFHLAISKANEENEDLQLHGVS 71
            ||::.:..:  |..||  ....:|.::|..| |:.      |..|..:.:..|.....|....::
  Rat    18 GFLVCAFWI--PDSRGMPHVIRIGGIFEYADGPNAQVMNAEEHAFRFSANIINRNRTLLPNTTLT 80

  Fly    72 VSIEP---GNSFETSKKLCKMLRQNLVAVFGPTSNLAARHAMSICDAKELPFLDTRWDF----GA 129
            ..|:.   .:|||.:||.|..|...:||:|||:.........|||:|.|:|.:..||..    ..
  Rat    81 YDIQRIHFHDSFEATKKACDQLALGVVAIFGPSQGSCTNAVQSICNALEVPHIQLRWKHHPLDNK 145

  Fly   130 QLPTINLHPHPATLGVALRDMVVALGWESFTIIYESGEYLPTVRELLQMYGTAGPTVTVRRYELD 194
            ....:||:|..|:|..|:.|:|.:|.|.|.|::|:....|..::||:.........:.:|:..:|
  Rat   146 DTFYVNLYPDYASLSHAILDLVQSLKWRSATVVYDDSTGLIRLQELIMAPSRYNIRLKIRQLPID 210

  Fly   195 LNGNYRNVLRRIRNADDFSFVVVGSMATLPEFFKQAQQVGLVTSDYRYIIGNLDWHTMDLEPYQH 259
             :.:.|.:|:.::...:|..:...|.....:..|||..:|::|..|.:|...||.:.:|||||::
  Rat   211 -SDDSRPLLKEMKRGREFRIIFDCSHTMAAQILKQAMAMGMMTEYYHFIFTTLDLYALDLEPYRY 274

  Fly   260 AGTNITGLRLVSPDSEQVQEVAKALYESEEPFQNVSCPLTNS----------MALVYDGVQLLAE 314
            :|.|:||.|:::.|:..|..:.:..  |.|..|  :.|...|          .||:||.|.:::.
  Rat   275 SGVNLTGFRILNVDNPHVSAIVEKW--SMERLQ--AAPRAESGLLDGVMMTDAALLYDAVHIVSV 335

  Fly   315 TYKHVNFRPV-ALSCNDDSAWDKGYTLVNYMKSLTLNGLTGPIRFD-YEGLRTDFKLEVIELAVS 377
            .|:......| :|.|:...||..|...:|::|.....||||.|.|: ..||||||.|::|.|...
  Rat   336 CYQRAPQMTVNSLQCHRHKAWRFGGRFMNFIKEAQWEGLTGRIVFNKTSGLRTDFDLDIISLKED 400

  Fly   378 GMQKIGQWSGEDGFQENRPAPAHSLEPDMR-SLVNKSFVVITAISEPYGMLKETSEKLEGNDQFE 441
            |::|:|.||..||.  |....|....|::. ||.|:|.:|.|.:.||:.|.:::...|.|||:||
  Rat   401 GLEKVGVWSPADGL--NITEVAKGRGPNVTDSLTNRSLIVTTLLEEPFVMFRKSDRTLYGNDRFE 463

  Fly   442 GFGIELIDELSKKLGFSYTWRLQEDNKYGGIDPKTGEWNGMLREIIDSRADMGITDLTMTSERES 506
            |:.|:|:.||:..|||||..||.||.|||..|.| |:||||::|:||.:||:.:..||:|..||.
  Rat   464 GYCIDLLKELAHILGFSYEIRLVEDGKYGAQDDK-GQWNGMVKELIDHKADLAVAPLTITHVREK 527

  Fly   507 GVDFTIPFMSLGIGILFRKPMKEPPKLFSFMSPFSGEVWLWLGLAYMGVSISMFVLGRLSPAEWD 571
            .:||:.|||:||:.||:|||....|.:|||::|.|.::|:::.|||:|||..:||:.|.||.||.
  Rat   528 AIDFSKPFMTLGVSILYRKPNGTNPSVFSFLNPLSPDIWMYVLLAYLGVSCVLFVIARFSPYEWY 592

  Fly   572 NPYPCIEEPTELENQFSFANCLWFSIGALLQQGSELAPKAYSTRAVAASWWFFTLILVSSYTANL 636
            :.:||......:||.|:..|..||.:|:|:||||||.|||.|||.:...|||||||::|||||||
  Rat   593 DAHPCNPGSEVVENNFTLLNSFWFGMGSLMQQGSELMPKALSTRIIGGIWWFFTLIIISSYTANL 657

  Fly   637 AAFLTVESLVTPINDADDLSKNKGGVNYGAKIGGATFNFFKESNYPTYQRMYEFMRDNPQYMTNT 701
            |||||||.:.:||:.||||:| :..:.|||...|||..|||:|...|:::|:.||...|..:...
  Rat   658 AAFLTVERMESPIDSADDLAK-QTKIEYGAVKDGATMTFFKKSKISTFEKMWAFMSSKPSALVKN 721

  Fly   702 NQEGVDRVENSNYAFLMESTTIEYITERRCTLTQVGALLDEKGYGIAMRKNWPYRDTLSQAVLEM 766
            |:||:.|...::||.|||||||||||:|.|.|||:|.|:|.|||||......||||.::.|:|::
  Rat   722 NEEGIQRTLTADYALLMESTTIEYITQRNCNLTQIGGLIDSKGYGIGTPMGSPYRDKITIAILQL 786

  Fly   767 QEQGLLTKMKTKWWQEKRGGGACSDADEDSGAVALEISNLGGVFLVMGVGSFFGIFVSLLEMVLG 831
            ||:..|..||.|||   ||.| |.: :|:..|.||.|..:||:|:|:..|....:.|::.|.:..
  Rat   787 QEEDKLHIMKEKWW---RGSG-CPE-EENKEASALGIQKIGGIFIVLAAGLVLSVLVAVGEFIYK 846

  Fly   832 VKERSDENQVSFKTELLDEIRFILQCSGNTKAVKYPKNSSRSNA 875
            :::.::..|.||.:.:.|||||.|.|....|....|....:::|
  Rat   847 LRKTAEREQRSFCSTVADEIRFSLTCQRRLKHKPQPPMMVKTDA 890

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Grik	NP_001262788.1	PBP1_iGluR_Kainate	37..391	CDD:107377	112/379 (30%)
		ANF_receptor	53..374	CDD:279440	99/339 (29%)
		Periplasmic_Binding_Protein_Type_2	411..781	CDD:304360	187/369 (51%)
		Lig_chan	543..816	CDD:278489	136/272 (50%)
Grik3	NP_001106187.1	PBP1_iGluR_Kainate_GluR5_7	34..417	CDD:107388	114/389 (29%)
		ANF_receptor	55..398	CDD:279440	101/347 (29%)
		PBP2_iGluR_Kainate_GluR7	433..801	CDD:270441	188/372 (51%)
		Lig_chan	564..832	CDD:278489	136/273 (50%)
		Glutamate binding	690..692		1/1 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349879
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	1	1.010	-	-		D60688at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.760