Protein Alignment Grik and Grik1

DIOPT Version :10

• Sequence 1: NP_001262788.1
• Gene: Grik / 42476
• FlyBaseID: FBgn0038840
• Length: 907
• Species: Drosophila melanogaster
• Sequence 2: NP_001104587.1
• Gene: Grik1 / 29559
• RGDID: 2732
• Length: 949
• Species: Rattus norvegicus
• Alignment Length: 940
• Identity: 335/940 - (35%)
• Similarity: 519/940 - (55%)
• Gaps: 79/940 - (8%)

  Fly     1 MWFVKMISTEASFPLGFILTSLLLAFPGCRGERTNVGLVY---ENTDPDLEKI-FHLAISKANEE 61
            :|     :.:.|:.|.:.|..:|   |....:...:|.::   ||...::|:: |..|::..|..
  Rat    12 LW-----TRDTSWTLLYFLCYIL---PQTSPQVLRIGGIFETVENEPVNVEELAFKFAVTSINRN 68

  Fly    62 NEDLQLHGVSVSIEPGN---SFETSKKLCKMLRQNLVAVFGPTSNLAARHAMSICDAKELPFLDT 123
            ...:....::..|:..|   |||.|::.|..|...:.|:|||:.:.:.....|||:|.|:|.:.|
  Rat    69 RTLMPNTTLTYDIQRINLFDSFEASRRACDQLALGVAALFGPSHSSSVSAVQSICNALEVPHIQT 133

  Fly   124 RWDF----GAQLPTINLHPHPATLGVALRDMVVALGWESFTIIYESGEYLPTVRELLQMYGTAGP 184
            ||..    ...|..|||:|..|.:..|:.|:|:...|::.|::||....|..::||::.......
  Rat   134 RWKHPSVDSRDLFYINLYPDYAAISRAVLDLVLYYNWKTVTVVYEDSTGLIRLQELIKAPSRYNI 198

  Fly   185 TVTVRRYELDLNGNYRNVLRRIRNADDFSFVVVGSMATLPEFFKQAQQVGLVTSDYRYIIGNLDW 249
            .:.:|:.. ..|.:.:.:|:.::.:.:|..:...|..|..|..||...:|::|..|.|....||.
  Rat   199 KIKIRQLP-PANKDAKPLLKEMKKSKEFYVIFDCSHETAAEILKQILFMGMMTEYYHYFFTTLDL 262

  Fly   250 HTMDLEPYQHAGTNITGLRLVSPDSEQVQEVAKALYESEEPFQNVSCP--------LTNSMALVY 306
            ..:|||.|:::|.|:||.||::.|:..|..:.:..  |.|..|....|        :|...||:|
  Rat   263 FALDLELYRYSGVNMTGFRLLNIDNPHVSSIIEKW--SMERLQAPPRPETGLLDGMMTTEAALMY 325

  Fly   307 DGVQLLA-ETYKHVNFRPVALSCNDDSAWDKGYTLVNYMKSLTLNGLTGPIRFD-YEGLRTDFKL 369
            |.|.::| .:::.......:|.|:....|..|...:|.:|....:||||.|.|: .:|||.||.|
  Rat   326 DAVYMVAIASHRASQLTVSSLQCHRHKPWRLGPRFMNLIKEARWDGLTGRITFNKTDGLRKDFDL 390

  Fly   370 EVIELAVSGMQ---------------KIGQWSGEDGF---QENRPAPAHSLEPDMRSLVNKSFVV 416
            ::|.|...|.:               |||.|:...|.   ..||....:..:    ||.|::.:|
  Rat   391 DIISLKEEGTEKASGEVSKHLYKVWKKIGIWNSNSGLNMTDGNRDRSNNITD----SLANRTLIV 451

  Fly   417 ITAISEPYGMLKETSEKLEGNDQFEGFGIELIDELSKKLGFSYTWRLQEDNKYGGIDPKTGEWNG 481
            .|.:.|||.|.:::.:.|.|||:|||:.::|:.|||..|||.|..:|..|.|||..:.| |||||
  Rat   452 TTILEEPYVMYRKSDKPLYGNDRFEGYCLDLLKELSNILGFLYDVKLVPDGKYGAQNDK-GEWNG 515

  Fly   482 MLREIIDSRADMGITDLTMTSERESGVDFTIPFMSLGIGILFRKPMKEPPKLFSFMSPFSGEVWL 546
            |::|:||.|||:.:..||:|..||..:||:.|||:|||.||:|||....|.:|||::|.|.::|:
  Rat   516 MVKELIDHRADLAVAPLTITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLSPDIWM 580

  Fly   547 WLGLAYMGVSISMFVLGRLSPAEWDNPYPCIEEPTELENQFSFANCLWFSIGALLQQGSELAPKA 611
            ::.||.:|||..:||:.|.:|.||.||:||..:...:||.|:..|..||.:|||:||||||.|||
  Rat   581 YVLLACLGVSCVLFVIARFTPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSELMPKA 645

  Fly   612 YSTRAVAASWWFFTLILVSSYTANLAAFLTVESLVTPINDADDLSKNKGGVNYGAKIGGATFNFF 676
            .|||.|...|||||||::||||||||||||||.:.:||:.||||:| :..:.|||...|:|..||
  Rat   646 LSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAK-QTKIEYGAVRDGSTMTFF 709

  Fly   677 KESNYPTYQRMYEFMRDNPQ-YMTNTNQEGVDRVENSNYAFLMESTTIEYITERRCTLTQVGALL 740
            |:|...||::|:.||....| .:...:.||:.||..::||.|||||:|||:|:|.|.|||:|.|:
  Rat   710 KKSKISTYEKMWAFMSSRQQSALVKNSDEGIQRVLTTDYALLMESTSIEYVTQRNCNLTQIGGLI 774

  Fly   741 DEKGYGIAMRKNWPYRDTLSQAVLEMQEQGLLTKMKTKWWQEKRGGGACSDADEDSGAVALEISN 805
            |.||||:......||||.::.|:|::||:|.|..||.|||   ||.| |.:.|... |.||.:.|
  Rat   775 DSKGYGVGTPIGSPYRDKITIAILQLQEEGKLHMMKEKWW---RGNG-CPEEDSKE-ASALGVEN 834

  Fly   806 LGGVFLVMGVGSFFGIFVSLLEMVLGVKERSDENQVSFKTEL----LDEIRF---ILQCSGNTKA 863
            :||:|:|:..|....:||::.|.:...::.:|..|....:.|    .:::||   ..:..|..|.
  Rat   835 IGGIFIVLAAGLVLSVFVAIGEFLYKSRKNNDVEQKGKSSRLRFYFRNKVRFHGSKKESLGVEKC 899

  Fly   864 VKYP----------KNSSRSNASSKSKGSS 883
            :.:.          ||..:....|::||.|
  Rat   900 LSFNAIMEELGISLKNQKKLKKKSRTKGKS 929

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Grik	NP_001262788.1	PBP1_iGluR_Kainate	35..395	CDD:380605	108/398 (27%)
		Periplasmic_Binding_Protein_Type_2	411..781	CDD:473866	186/370 (50%)
Grik1	NP_001104587.1	PBP1_iGluR_Kainate	38..431	CDD:380605	108/395 (27%)
		Periplasmic_Binding_Protein_Type_2	446..815	CDD:473866	187/373 (50%)