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Protein Alignment Grik and GRIN2D

DIOPT Version :9

Sequence 1:	NP_001262788.1	Gene:	Grik / 42476	FlyBaseID:	FBgn0038840	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	NP_000827.2	Gene:	GRIN2D / 2906	HGNCID:	4588	Length:	1336	Species:	Homo sapiens

Alignment Length:	923	Identity:	203/923 - (21%)
Similarity:	338/923 - (36%)	Gaps:	240/923 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 PGNSFETSKKLCKMLRQNLVAVF-GPT-SNLAARHAMSICDAKELPFLDTRWDFGAQLPTINLHP 138
            ||.....::.|      |:..|| ||. :..|||...::..|...|.||.|
Human    41 PGGGLGGARPL------NVALVFSGPAYAAEAARLGPAVAAAVRSPGLDVR-------------- 85

  Fly   139 HPATL---GVALRDMVVAL-----GWESFTIIYESGEYLPTVRELLQMYG--TAGPTVTVRRYEL 193
             |..|   |...|.:|:.|     |.....:::|.....|.|..:|....  |:.|.|.|
Human    86 -PVALVLNGSDPRSLVLQLCDLLSGLRVHGVVFEDDSRAPAVAPILDFLSAQTSLPIVAV----- 144

  Fly   194 DLNGNYRNVLRRIRNADDFSFVVVGSMATLPEFFKQAQQVGLVTSDYRYIIGNLDWHTM------ 252
              :|....||.......  :|:.:||...     :|.|.:..|..:|       ||.:.
Human   145 --HGGAALVLTPKEKGS--TFLQLGSSTE-----QQLQVIFEVLEEY-------DWTSFVAVTTR 193

  Fly   253 -----------------DLEPYQHAGT-----------------NITG-LRLVSPDSEQVQEVAK 282
                             .|..::|.|.                 :::. :||:....|:.:.|.:
Human   194 APGHRAFLSYIEVLTDGSLVGWEHRGALTLDPGAGEAVLSAQLRSVSAQIRLLFCAREEAEPVFR 258

  Fly   283 ALYES--------------------------EEPFQNVSCPL--------------------TNS 301
            |..|:                          |.|......||                    ...
Human   259 AAEEAGLTGSGYVWFMVGPQLAGGGGSGAPGEPPLLPGGAPLPAGLFAVRSAGWRDDLARRVAAG 323

  Fly   302 MALVYDGVQLLAETYKHVNFRP-VALSCNDDSAWDKGYTLVNYMKSLTLNGLTGPIRFDYEGLRT 365
            :|:|..|.|.|...|   .|.| :...|...:...:|.:|..|..::|.:  .....|:.:|...
Human   324 VAVVARGAQALLRDY---GFLPELGHDCRAQNRTHRGESLHRYFMNITWD--NRDYSFNEDGFLV 383

  Fly   366 DFKLEVIELAVS-GMQKIGQWSGEDGFQENRP---APAHSLEP-------DMRSLVNKSFVVITA 419
            :..|.||.|... ..:.:|.|. :...:...|   .....|:|       .:.:|..:.||::
Human   384 NPSLVVISLTRDRTWEVVGSWE-QQTLRLKYPLWSRYGRFLQPVDDTQHLTVATLEERPFVIV-- 445

  Fly   420 ISEPYGMLKET--SEKLEGNDQF------------------EGFGIELIDELSKKLGFSYTWRLQ 464
              ||...:..|  .:.:....|.                  :||.|:::..|:..:||||...|.
Human   446 --EPADPISGTCIRDSVPCRSQLNRTHSPPPDAPRPEKRCCKGFCIDILKRLAHTIGFSYDLYLV 508

  Fly   465 EDNKYG-GIDPKTGEWNGMLREIIDSRADMGITDLTMTSERESGVDFTIPFMSLGIGILF-RKPM 527
            .:.|:| .||   |.||||:.|:...||||.|..||:..||...|||::||:..||.::. |...
Human   509 TNGKHGKKID---GVWNGMIGEVFYQRADMAIGSLTINEERSEIVDFSVPFVETGISVMVARSNG 570

  Fly   528 KEPPKLFSFMSPFSGEVWLWLGLAYMG-VSISMFVLGRLSPAEWDNPYPCIEEPTELENQFSFAN 591
            ...|.  :|:.|:|..||:.:.:..:. |::::|:...|||..::......:.|.  .:.|:...
Human   571 TVSPS--AFLEPYSPAVWVMMFVMCLTVVAVTVFIFEYLSPVGYNRSLATGKRPG--GSTFTIGK 631

  Fly   592 CLWFSIGALLQQGSELA--PKAYSTRAVAASWWFFTLILVSSYTANLAAFLTVESLVTPINDADD 654
            .:|. :.||:...|...  |:..:::.:...|.||.:|.::|||||||||:..|..|..::...|
Human   632 SIWL-LWALVFNNSVPVENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEEYVDTVSGLSD 695

  Fly   655 LSKNKGGVNY-----GAKIGGATFNFFKESNYPTYQRMYEFMRDNPQYMTNTNQEGVDRVENSNY 714
            ....:....|     |....|:|....: ||||          |...||...||   .|||.:..
Human   696 RKFQRPQEQYPPLKFGTVPNGSTEKNIR-SNYP----------DMHSYMVRYNQ---PRVEEALT 746

  Fly   715 --------AFLMESTTIEYIT--ERRCTLTQVGA--LLDEKGYGIAMRKNWPYRDTLSQAVLEMQ 767
                    ||:.::..:.|:.  :..|.|..:|:  :....|||||:.|...::..:..|:|:..
Human   747 QLKAGKLDAFIYDAAVLNYMARKDEGCKLVTIGSGKVFATTGYGIALHKGSRWKRPIDLALLQFL 811

  Fly   768 EQGLLTKMKTKWWQEKRGGGACSDADEDSGAVALEISNLGGVFLVMGVGSFFGIFVSLLEMV--- 829
            ....:..::..|.     .|.|.:...:..:..|:|.|:.|||.::.|.....:.|...|.:
Human   812 GDDEIEMLERLWL-----SGICHNDKIEVMSSKLDIDNMAGVFYMLLVAMGLSLLVFAWEHLVYW 871

  Fly   830 -----LGVKERSD 837
                 ||...|.|
Human   872 RLRHCLGPTHRMD 884

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.