Protein Alignment Grik and GRIN2C

DIOPT Version :9

• Sequence 1: NP_001262788.1
• Gene: Grik / 42476
• FlyBaseID: FBgn0038840
• Length: 907
• Species: Drosophila melanogaster
• Sequence 2: XP_016880033.1
• Gene: GRIN2C / 2905
• HGNCID: 4587
• Length: 1337
• Species: Homo sapiens
• Alignment Length: 1010
• Identity: 229/1010 - (22%)
• Similarity: 394/1010 - (39%)
• Gaps: 235/1010 - (23%)

  Fly    18 ILTSLLLAFPGC---RGER-TNVGLVYENTDPDLEKIFHLAISKANEENEDLQLHGVSVSIEPGN 78
            :||||..|:.|.   :||: ..|.:|:.::.|. :..|...::..:..:..|::..::|.:...|
Human    85 LLTSLFGAWAGLGPGQGEQGMTVAVVFSSSGPP-QAQFRARLTPQSFLDLPLEIQPLTVGVNTTN 148

  Fly    79 SFETSKKLCKMLRQNLVAVFGPTSNLAARHAMSI---------CDAKELPFLDTRWDFGAQLPTI 134
            ......::|.:              |.|.|...|         ..|:.|.|:.::    ..:|.:
Human   149 PSSLLTQICGL--------------LGAAHVHGIVFEDNVDTEAVAQILDFISSQ----THVPIL 195

  Fly   135 NLHPHPAT-------------LGVALRDMVVAL-------GWESFTII--YESGE--YLPTVREL 175
            ::....|.             |||:|...:..|       .|.:|.:|  ...|.  :|..||.:
Human   196 SISGGSAVVLTPKEPGSAFLQLGVSLEQQLQVLFKVLEEYDWSAFAVITSLHPGHALFLEGVRAV 260

  Fly   176 LQMYGTAGPTVTVRRYELDLNGNYRNVLRRIRNADDFSFVVVGSMATLPEFFKQAQQVGLVTSDY 240
            ......:...:.|...||...|......|.:|..|...||...|.......|.:|.|.|||...:
Human   261 ADASHVSWRLLDVVTLELGPGGPRARTQRLLRQLDAPVFVAYCSREEAEVLFAEAAQAGLVGPGH 325

  Fly   241 RYIIGNLDWHTMDLEPYQHAGTNITGLRLVSPDSEQVQEVAKALYESEEPFQNVSCPLTNSMALV 305
            .:::.||...:.|..|    .|...||..|..:|.::....|                      |
Human   326 VWLVPNLALGSTDAPP----ATFPVGLISVVTESWRLSLRQK----------------------V 364

  Fly   306 YDGVQLLAETYKHVNFRPVALSCNDDSAWDKGYTLVNYMKSLTLN-GLTGPIR---------FDY 360
            .|||.:||              ....|.|.:..||........:: |...|.|         ..:
Human   365 RDGVAILA--------------LGAHSYWRQHGTLPAPAGDCRVHPGPVSPAREAFYRHLLNVTW 415

  Fly   361 EGLRTDFKLE---------VIELAVSG---MQKIGQWSGEDGFQENR----PAPAHSLEP--DMR 407
            ||  .||...         ::.:|::.   .:.:|:|  |.|....:    |..:.||:|  |.|
Human   416 EG--RDFSFSPGGYLVQPTMVVIALNRHRLWEMVGRW--EHGVLYMKYPVWPRYSASLQPVVDSR 476

  Fly   408 -----SLVNKSFVVITAISEP--YGMLKETSE-KLEGNDQF-------------EGFGIELIDEL 451
                 :|..:.||::.: .:|  .|.:..|.. :.:.|..|             :||.|:::.:|
Human   477 HLTVATLEERPFVIVES-PDPGTGGCVPNTVPCRRQSNHTFSSGDVAPYTKLCCKGFCIDILKKL 540

  Fly   452 SKKLGFSYTWRLQEDNKYGGIDPKTGEWNGMLREIIDSRADMGITDLTMTSERESGVDFTIPFMS 516
            ::.:.|||...|..:.|:|  ....|.||||:.|:...||||.|..||:..||...|||::||:.
Human   541 ARVVKFSYDLYLVTNGKHG--KRVRGVWNGMIGEVYYKRADMAIGSLTINEERSEIVDFSVPFVE 603

  Fly   517 LGIGILF-RKPMKEPPKLFSFMSPFSGEVWLWLGLAYMG-VSISMFVLGRLSPAEWDNPYPCIEE 579
            .||.::. |......|.  :|:.|:|..||:.:.:..:. |:|::|:....||..:
Human   604 TGISVMVARSNGTVSPS--AFLEPYSPAVWVMMFVMCLTVVAITVFMFEYFSPVSY--------- 657

  Fly   580 PTELENQ------------FSFANCLWFSIGALLQQGSELA--PKAYSTRAVAASWWFFTLILVS 630
                 ||            |:....:|. :.||:...|...  |:..:::.:...|.||.:|.::
Human   658 -----NQNLTRGKKSGGPAFTIGKSVWL-LWALVFNNSVPIENPRGTTSKIMVLVWAFFAVIFLA 716

  Fly   631 SYTANLAAFLTVE---SLVTPINDADDLSKNKGGVNYGAKIGGATF--NFFK--ESNYP------ 682
            |||||||||:..|   ..|:.::|...|.....||.:.|   ..||  ::|:  :..||
Human   717 SYTANLAAFMIQEQYIDTVSGLSDKKSLHLENTGVAWTA---FKTFCSDYFQRPQDQYPPFRFGT 778

  Fly   683 -----TYQRMYEFMRDNPQYMTNTNQEGVD-------------RVENSNYAFLMESTTIEYIT-- 727
                 |.:.:....||...:|...||..|:             .|.....||:.::..:.|:.
Human   779 VPNGSTERNIRSNYRDMHTHMVKFNQRSVEDALTSLKMGSEAQPVPRKLDAFIYDAAVLNYMAGK 843

  Fly   728 ERRCTLTQVGA--LLDEKGYGIAMRKNWPYRDTLSQAVLEMQEQGLLTKMKTKWWQEKRGGGACS 790
            :..|.|..:|:  :....||||||:|:..::..:..|:|:....|...|::|.|.     .|.|.
Human   844 DEGCKLVTIGSGKVFATTGYGIAMQKDSHWKRAIDLALLQFLGDGETQKLETVWL-----SGICQ 903

  Fly   791 DADEDSGAVALEISNLGGVFLVMGVGSFFGIFVSLLEMVLGVKER---SDENQVSFKTELLDEIR 852
            :...:..:..|:|.|:.|||.::.|.....:.|...|.::..|.|   .:.:|:.|   ||...|
Human   904 NEKNEVMSSKLDIDNMAGVFYMLLVAMGLALLVFAWEHLVYWKLRHSVPNSSQLDF---LLAFSR 965

  Fly   853 FILQC-SGNTKAVKYPKNSSRSNASSKSKGSSMSV 886
            .|..| ||.......|:.:|....:|.::.|.:.:
Human   966 GIYSCFSGVQSLASPPRQASPDLTASSAQASVLKM 1000

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Grik	NP_001262788.1	PBP1_iGluR_Kainate	37..391	CDD:107377	75/408 (18%)
		ANF_receptor	53..374	CDD:279440	68/372 (18%)
		Periplasmic_Binding_Protein_Type_2	411..781	CDD:304360	111/436 (25%)
		Lig_chan	543..816	CDD:278489	75/322 (23%)
GRIN2C	XP_016880033.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155968
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840