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Protein Alignment Grik and GRIN2B

DIOPT Version :9

Sequence 1:	NP_001262788.1	Gene:	Grik / 42476	FlyBaseID:	FBgn0038840	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	NP_000825.2	Gene:	GRIN2B / 2904	HGNCID:	4586	Length:	1484	Species:	Homo sapiens

Alignment Length:	1025	Identity:	214/1025 - (20%)
Similarity:	395/1025 - (38%)	Gaps:	224/1025 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 FILTSLLLAFPGCRGE------RTNVGLVYENTDPDLEKIFHLAISKANEENEDLQLHGVSV--S 73
            |.|...:||..|.|..      ...:.::...|..:      :||..|:|:::   .|.:||  .
Human    12 FWLVLAVLAVSGSRARSQKSPPSIGIAVILVGTSDE------VAIKDAHEKDD---FHHLSVVPR 67

  Fly    74 IEPGNSFETSKK-----LCKMLRQNLV--AVFGPTSNLAARHAMSICDAKELPFLDTRWDFGAQL 131
            :|.....||..|     :|.::....:  .||...::..|       .|:.|.|:..:    ...
Human    68 VELVAMNETDPKSIITRICDLMSDRKIQGVVFADDTDQEA-------IAQILDFISAQ----TLT 121

  Fly   132 PTINLH--------------------PHPATLGVALRDMVVALGWESFTII--YESG--EYLPTV 172
            |.:.:|                    |........:.:::....|..|:|:  |..|  :::..:
Human   122 PILGIHGGSSMIMADKDESSMFFQFGPSIEQQASVMLNIMEEYDWYIFSIVTTYFPGYQDFVNKI 186

  Fly   173 RELLQMYGTAGPTVTVRRYELDL---NGNYRNVLRRIRNADDFSFVVVGSMATLPE---FFKQAQ 231
            |..::..........|...::.|   :...:|.|:::::.      ::....|..|   .|:.|.
Human   187 RSTIENSFVGWELEEVLLLDMSLDDGDSKIQNQLKKLQSP------IILLYCTKEEATYIFEVAN 245

  Fly   232 QVGLVTSDYRYIIGNLDWHTMDLEPYQHAGTNITGLRLVSPDSEQVQEVAKALYESEEPFQNVSC 296
            .|||....|.:|:.:|.....|..|.:..    |||..||.|.                 .:...
Human   246 SVGLTGYGYTWIVPSLVAGDTDTVPAEFP----TGLISVSYDE-----------------WDYGL 289

  Fly   297 PLTNSMALVYDGVQLL----AETYKHVNFRPVALSCNDDSAWDKGY---TLVNYMKSLTLNGLTG 354
            |     |.|.||:.::    ::.....:|.|...|...::...:.|   .|..|:.::|..|..
Human   290 P-----ARVRDGIAIITTAASDMLSEHSFIPEPKSSCYNTHEKRIYQSNMLNRYLINVTFEGRN- 348

  Fly   355 PIRFDYEGLRTDFKLEVIEL-AVSGMQKIGQWSGEDGFQEN-----RPAP-AHSLEPDMRSLV-- 410
             :.|..:|.:...||.:|.| .....:::|:|. :...|..     |..| ....|.|..|:|
Human   349 -LSFSEDGYQMHPKLVIILLNKERKWERVGKWK-DKSLQMKYYVWPRMCPETEEQEDDHLSIVTL 411

  Fly   411 -NKSFVVITAISEPYGMLKE----------TSEKLEGNDQF-----EGFGIELIDELSKKLGFSY 459
             ...||::.::....|....          |..|.:....:     :||.|:::.::||.:.|:|
Human   412 EEAPFVIVESVDPLSGTCMRNTVPCQKRIVTENKTDEEPGYIKKCCKGFCIDILKKISKSVKFTY 476

  Fly   460 TWRLQEDNKYGGIDPKTGEWNGMLREIIDSRADMGITDLTMTSERESGVDFTIPFMSLGIGILF- 523
            ...|..:.|:|  ....|.||||:.|::..||.|.:..||:..||...|||::||:..||.::.
Human   477 DLYLVTNGKHG--KKINGTWNGMIGEVVMKRAYMAVGSLTINEERSEVVDFSVPFIETGISVMVS 539

  Fly   524 RKPMKEPPKLFSFMSPFSGEVWLWLGLAYMGVS-ISMFVLGRLSPAEWDNPYPCIEEPTELEN-Q 586
            |......|.  :|:.|||.:||:.:.:..:.|| :::||....||..::.   |:.:..|... .
Human   540 RSNGTVSPS--AFLEPFSADVWVMMFVMLLIVSAVAVFVFEYFSPVGYNR---CLADGREPGGPS 599

  Fly   587 FSFANCLWFSIGALLQQGSELA-PKAYSTRAVAASWWFFTLILVSSYTANLAAFLTVESLVTPIN 650
            |:....:|...|.:......:. ||..:::.:.:.|.||.:|.::|||||||||:..|..|..::
Human   600 FTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEYVDQVS 664

  Fly   651 DADDLSKNKGG-----VNYGAKIGGATFNFFKESNYPTYQRMYEFMRDNPQYMTNTNQEGVD--- 707
            ...|....:..     ..:|....|:|....:.:    |..|:       .||...||.|||
Human   665 GLSDKKFQRPNDFSPPFRFGTVPNGSTERNIRNN----YAEMH-------AYMGKFNQRGVDDAL 718

  Fly   708 ------RVENSNYAFLMESTTIEYITER--RCTLTQVGA--LLDEKGYGIAMRKNWPYRDTLSQA 762
                  :::    ||:.::..:.|:..|  .|.|..:|:  :....|||||::|:..::..:..|
Human   719 LSLKTGKLD----AFIYDAAVLNYMAGRDEGCKLVTIGSGKVFASTGYGIAIQKDSGWKRQVDLA 779

  Fly   763 VLEMQEQGLLTKMKTKWWQEKRGGGACSDADEDSGAVALEISNLGGVFLVMGV------------ 815
            :|::...|.:.:::..|..     |.|.:...:..:..|:|.|:.|||.::|.
Human   780 ILQLFGDGEMEELEALWLT-----GICHNEKNEVMSSQLDIDNMAGVFYMLGAAMALSLITFICE 839

  Fly   816 -------------------GSFFGIFVSLLEMVLGVKERSDENQVSFKTELLDE-----IRFILQ 856
                               |..|.|...:...:.||.....::.::..|..::.     :|.:
Human   840 HLFYWQFRHCFMGVCSGKPGMVFSISRGIYSCIHGVAIEERQSVMNSPTATMNNTHSNILRLL-- 902

  Fly   857 CSGNTKAVKYPKNSSRSNASSKSKGSSMSVDSLPEDTSEADASGKHNHGK 906
                 :..|...|.|..|.|.:|....:..:|...|.||...|..|:..|
Human   903 -----RTAKNMANLSGVNGSPQSALDFIRRESSVYDISEHRRSFTHSDCK 947

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.