DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Grik and GRIN1

DIOPT Version :9

Sequence 1:	NP_001262788.1	Gene:	Grik / 42476	FlyBaseID:	FBgn0038840	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	XP_005266130.1	Gene:	GRIN1 / 2902	HGNCID:	4584	Length:	959	Species:	Homo sapiens

Alignment Length:	1001	Identity:	228/1001 - (22%)
Similarity:	409/1001 - (40%)	Gaps:	201/1001 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 ILTSLLLAFPGCRGERTNVGLVYENTDPDLEKIFHLAISKANEENED--LQLHGVSVSIEPGNSF 80
            :|.|..:|...|..:..|:|.|......  |::|..|:::||:.:..  :||:..||:.:| |:.
Human    11 LLFSCSVARAACDPKIVNIGAVLSTRKH--EQMFREAVNQANKRHGSWKIQLNATSVTHKP-NAI 72

  Fly    81 ETSKKLCK-MLRQNLVAVF---GPTSN-------------------LAARHAMSICDAKELPFLD 122
            :.:..:|: ::...:.|:.   .||.|                   |.....|||...|.:..
Human    73 QMALSVCEDLISSQVYAILVSHPPTPNDHFTPTPVSYTAGFYRIPVLGLTTRMSIYSDKSIHL-- 135

  Fly   123 TRWDFGAQLPTINLHPHPATLGVALRDMVVALGWESFTII----YESGEYLPTVRELLQMYGTAG 183
                  :.|.|:..:.|.:::..   :|:....|....::    :|.......:..||:...:..
Human   136 ------SFLRTVPPYSHQSSVWF---EMMRVYSWNHIILLVSDDHEGRAAQKRLETLLEERESKS 191

  Fly   184 PTVTVRRYE------------------LDLNGNYRNVLRRIRNADDFSFVVV------GSMATLP 224
            ..   |.||                  |..:...:||...:..|.:....|:      ...||:
Human   192 KK---RNYENLDQLSYDNKRGPKAEKVLQFDPGTKNVTALLMEAKELEARVIILSASEDDAATV- 252

  Fly   225 EFFKQAQQVGLVTSDYRYIIGNLDWHTMDLEPYQHAGTNITGLRLVSPDSEQ------VQEVAKA 283
              ::.|..:.:..|.|.:::|..:   :.....::|...|.||:|::..:|.      |..||:|
Human   253 --YRAAAMLNMTGSGYVWLVGERE---ISGNALRYAPDGILGLQLINGKNESAHISDAVGVVAQA 312

  Fly   284 LYESEEPFQNVSCPLTNSMALVYDGVQLLAETYKHVNFRPVALSCNDDSAWDKGYTLVN-YMKSL 347
            ::|..|. :|::.|....:                          .:.:.|..|..... .|.|.
Human   313 VHELLEK-ENITDPPRGCV--------------------------GNTNIWKTGPLFKRVLMSSK 350

  Fly   348 TLNGLTGPIRFDYEGLRTDFKLEVIELAVSGMQKIGQWSGEDGFQENRPA--PAHSLEPDMRSLV 410
            ..:|:||.:.|:.:|.|......::.|....:.::|.::|......:|..  |....|......:
Human   351 YADGVTGRVEFNEDGDRKFANYSIMNLQNRKLVQVGIYNGTHVIPNDRKIIWPGGETEKPRGYQM 415

  Fly   411 NKSFVVITAISEPYGMLKETSEKLEGNDQFE-------------------------------GFG 444
            :....::|...||:..:|.|.......::|.                               ||.
Human   416 STRLKIVTIHQEPFVYVKPTLSDGTCKEEFTVNGDPVKKVICTGPNDTSPGSPRHTVPQCCYGFC 480

  Fly   445 IELIDELSKKLGFSYTWRLQEDNKYGGID----PKTGEWNGMLREIIDSRADMGITDLTMTSERE 505
            |:|:.:|::.:.|:|...|..|.|:|..:    ....|||||:.|::..:|||.:..||:.:||.
Human   481 IDLLIKLARTMNFTYEVHLVADGKFGTQERVNNSNKKEWNGMMGELLSGQADMIVAPLTINNERA 545

  Fly   506 SGVDFTIPFMSLGIGILFRKPMKEPPK--LFSFMSPFSGEVWLWLGLAYMGVSISMFVLGRLSPA 568
            ..::|:.||...|:.||.:   ||.|:  |.|||.||...:||.:||:...|::.:::|.|.||.
Human   546 QYIEFSKPFKYQGLTILVK---KEIPRSTLDSFMQPFQSTLWLLVGLSVHVVAVMLYLLDRFSPF 607

  Fly   569 EWDNPYPCIEEPTELENQFSFANCLWFSIGALLQQG-SELAPKAYSTRAVAASWWFFTLILVSSY 632
            ....    :....|.|:..:.::.:|||.|.||..| .|.||:::|.|.:...|..|.:|:|:||
Human   608 GRFK----VNSEEEEEDALTLSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVWAGFAMIIVASY 668

  Fly   633 TANLAAFLTV---ESLVTPINDADDLSKNKGGVNYGAKIGGATFNFF----KESNYPTYQR---- 686
            ||||||||.:   |..:|.|||              .::...:..|.    |:|:...|.|
Human   669 TANLAAFLVLDRPEERITGIND--------------PRLRNPSDKFIYATVKQSSVDIYFRRQVE 719

  Fly   687 ---MYEFMRDNPQYMTNTNQEGVDRV-ENSNYAFLMESTTIEYITERRCTLTQVGALLDEKGYGI 747
               ||..|.   ::...:..|.:..| :|..:||:.:|..:|:...::|.|...|.|....|:||
Human   720 LSTMYRHME---KHNYESAAEAIQAVRDNKLHAFIWDSAVLEFEASQKCDLVTTGELFFRSGFGI 781

  Fly   748 AMRKNWPYRDTLSQAVLEMQEQGLLTKMKTKW--WQEKRGGGACSDADEDSGAVA-LEISNLGGV 809
            .|||:.|::..:|.::|:..|.|.:..:...|  :||         .|..|.|.| |...|:.||
Human   782 GMRKDSPWKQNVSLSILKSHENGFMEDLDKTWVRYQE---------CDSRSNAPATLTFENMAGV 837

  Fly   810 FLVMGVGSFFGIFVSLLEMVLGVKERSDENQVSFKTELLDEIRFILQCSGNTKAVKYPKNSSRSN 874
            |:::..|...|||:..:|:.....:.:...|:......::..|..||...:.:|...||..:...
Human   838 FMLVAGGIVAGIFLIFIEIAYKRHKDARRKQMQLAFAAVNVWRKNLQDRKSGRAEPDPKKKATFR 902

  Fly   875 ASSKSKGSSMSVDSLPEDTSEADASG 900
            |.:.:..||.......:|||.....|
Human   903 AITSTLASSFKRRRSSKDTSTGGGRG 928

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Grik	NP_001262788.1	PBP1_iGluR_Kainate	37..391	CDD:107377	72/413 (17%)
		ANF_receptor	53..374	CDD:279440	65/380 (17%)
		Periplasmic_Binding_Protein_Type_2	411..781	CDD:304360	118/424 (28%)
		Lig_chan	543..816	CDD:278489	84/291 (29%)
GRIN1	XP_005266130.1	PBP1_iGluR_NMDA_NR1	25..404	CDD:380602	74/428 (17%)
		PBP2_iGluR_NMDA_Nr1	416..820	CDD:270437	120/436 (28%)
		CaM_bdg_C0	856..884	CDD:402271	2/27 (7%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910