DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Grik and GRIK3

DIOPT Version :9

Sequence 1:	NP_001262788.1	Gene:	Grik / 42476	FlyBaseID:	FBgn0038840	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	NP_000822.2	Gene:	GRIK3 / 2899	HGNCID:	4581	Length:	919	Species:	Homo sapiens

Alignment Length:	885	Identity:	341/885 - (38%)
Similarity:	511/885 - (57%)	Gaps:	45/885 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 LLLAF--PGCRG--ERTNVGLVYENTD-PDL------EKIFHLAISKANEENEDLQLHGVSVSIE 75
            |:.||  |..||  ....:|.::|..| |:.      |..|..:.:..|.....|....::..|:
Human    20 LVCAFWIPDSRGMPHVIRIGGIFEYADGPNAQVMNAEEHAFRFSANIINRNRTLLPNTTLTYDIQ 84

  Fly    76 P---GNSFETSKKLCKMLRQNLVAVFGPTSNLAARHAMSICDAKELPFLDTRWDF----GAQLPT 133
            .   .:|||.:||.|..|...:||:|||:.........|||:|.|:|.:..||..    ......
Human    85 RIHFHDSFEATKKACDQLALGVVAIFGPSQGSCTNAVQSICNALEVPHIQLRWKHHPLDNKDTFY 149

  Fly   134 INLHPHPATLGVALRDMVVALGWESFTIIYESGEYLPTVRELLQMYGTAGPTVTVRRYELDLNGN 198
            :||:|..|:|..|:.|:|..|.|.|.|::|:....|..::||:.........:.:|:..:| :.:
Human   150 VNLYPDYASLSHAILDLVQYLKWRSATVVYDDSTGLIRLQELIMAPSRYNIRLKIRQLPID-SDD 213

  Fly   199 YRNVLRRIRNADDFSFVVVGSMATLPEFFKQAQQVGLVTSDYRYIIGNLDWHTMDLEPYQHAGTN 263
            .|.:|:.::...:|..:...|.....:..|||..:|::|..|.:|...||.:.:|||||:::|.|
Human   214 SRPLLKEMKRGREFRIIFDCSHTMAAQILKQAMAMGMMTEYYHFIFTTLDLYALDLEPYRYSGVN 278

  Fly   264 ITGLRLVSPDSEQVQEVAKALYESEEPFQNVSCPLTNS----------MALVYDGVQLLAETYKH 318
            :||.|:::.|:..|..:.:..  |.|..|  :.|.:.|          .||:||.|.:::..|:.
Human   279 LTGFRILNVDNPHVSAIVEKW--SMERLQ--AAPRSESGLLDGVMMTDAALLYDAVHIVSVCYQR 339

  Fly   319 VNFRPV-ALSCNDDSAWDKGYTLVNYMKSLTLNGLTGPIRFD-YEGLRTDFKLEVIELAVSGMQK 381
            .....| :|.|:...||..|...:|::|.....||||.|.|: ..||||||.|::|.|...|::|
Human   340 APQMTVNSLQCHRHKAWRFGGRFMNFIKEAQWEGLTGRIVFNKTSGLRTDFDLDIISLKEDGLEK 404

  Fly   382 IGQWSGEDGFQENRPAPAHSLEPDMR-SLVNKSFVVITAISEPYGMLKETSEKLEGNDQFEGFGI 445
            :|.||..||.  |....|....|::. ||.|:|.:|.|.:.||:.|.:::...|.|||:|||:.|
Human   405 VGVWSPADGL--NITEVAKGRGPNVTDSLTNRSLIVTTVLEEPFVMFRKSDRTLYGNDRFEGYCI 467

  Fly   446 ELIDELSKKLGFSYTWRLQEDNKYGGIDPKTGEWNGMLREIIDSRADMGITDLTMTSERESGVDF 510
            :|:.||:..|||||..||.||.|||..|.| |:||||::|:||.:||:.:..||:|..||..:||
Human   468 DLLKELAHILGFSYEIRLVEDGKYGAQDDK-GQWNGMVKELIDHKADLAVAPLTITHVREKAIDF 531

  Fly   511 TIPFMSLGIGILFRKPMKEPPKLFSFMSPFSGEVWLWLGLAYMGVSISMFVLGRLSPAEWDNPYP 575
            :.|||:||:.||:|||....|.:|||::|.|.::|:::.|||:|||..:||:.|.||.||.:.:|
Human   532 SKPFMTLGVSILYRKPNGTNPSVFSFLNPLSPDIWMYVLLAYLGVSCVLFVIARFSPYEWYDAHP 596

  Fly   576 CIEEPTELENQFSFANCLWFSIGALLQQGSELAPKAYSTRAVAASWWFFTLILVSSYTANLAAFL 640
            |......:||.|:..|..||.:|:|:||||||.|||.|||.:...|||||||::|||||||||||
Human   597 CNPGSEVVENNFTLLNSFWFGMGSLMQQGSELMPKALSTRIIGGIWWFFTLIIISSYTANLAAFL 661

  Fly   641 TVESLVTPINDADDLSKNKGGVNYGAKIGGATFNFFKESNYPTYQRMYEFMRDNPQYMTNTNQEG 705
            |||.:.:||:.||||:| :..:.|||...|||..|||:|...|:::|:.||...|..:...|:||
Human   662 TVERMESPIDSADDLAK-QTKIEYGAVKDGATMTFFKKSKISTFEKMWAFMSSKPSALVKNNEEG 725

  Fly   706 VDRVENSNYAFLMESTTIEYITERRCTLTQVGALLDEKGYGIAMRKNWPYRDTLSQAVLEMQEQG 770
            :.|...::||.|||||||||:|:|.|.|||:|.|:|.|||||......||||.::.|:|::||:.
Human   726 IQRALTADYALLMESTTIEYVTQRNCNLTQIGGLIDSKGYGIGTPMGSPYRDKITIAILQLQEED 790

  Fly   771 LLTKMKTKWWQEKRGGGACSDADEDSGAVALEISNLGGVFLVMGVGSFFGIFVSLLEMVLGVKER 835
            .|..||.|||   ||.| |.: :|:..|.||.|..:||:|:|:..|....:.|::.|.|..:::.
Human   791 KLHIMKEKWW---RGSG-CPE-EENKEASALGIQKIGGIFIVLAAGLVLSVLVAVGEFVYKLRKT 850

  Fly   836 SDENQVSFKTELLDEIRFILQCSGNTKAVKYPKNSSRSNA 875
            ::..|.||.:.:.|||||.|.|....|....|....:::|
Human   851 AEREQRSFCSTVADEIRFSLTCQRRVKHKPQPPMMVKTDA 890

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Grik	NP_001262788.1	PBP1_iGluR_Kainate	37..391	CDD:107377	112/379 (30%)
		ANF_receptor	53..374	CDD:279440	99/339 (29%)
		Periplasmic_Binding_Protein_Type_2	411..781	CDD:304360	186/369 (50%)
		Lig_chan	543..816	CDD:278489	135/272 (50%)
GRIK3	NP_000822.2	PBP1_iGluR_Kainate_GluR5_7	34..417	CDD:107388	114/389 (29%)
		ANF_receptor	55..398	CDD:279440	101/347 (29%)
		PBP2_iGluR_Kainate_GluR7	433..801	CDD:270441	187/372 (50%)
		Lig_chan	564..832	CDD:278489	135/273 (49%)
		Glutamate binding. /evidence=ECO:0000250	690..692		1/1 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155962
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	1	1.010	-	-		D60688at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.760