DRSC/TRiP Functional Genomics Resources

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Protein Alignment Grik and GRIK2

DIOPT Version :9

Sequence 1:NP_001262788.1 Gene:Grik / 42476 FlyBaseID:FBgn0038840 Length:907 Species:Drosophila melanogaster
Sequence 2:NP_068775.1 Gene:GRIK2 / 2898 HGNCID:4580 Length:908 Species:Homo sapiens


Alignment Length:840 Identity:330/840 - (39%)
Similarity:495/840 - (58%) Gaps:42/840 - (5%)


- Green bases have known domain annotations that are detailed below.


  Fly    48 EKIFHLAISKANEE-----NEDLQLHGVSVSIEPGNSFETSKKLCKMLRQNLVAVFGPTSNLAAR 107
            |..|..|::..|..     |..|......:::.  :|||.|||.|..|...:.|:|||:.:.:|.
Human    54 ELAFRFAVNTINRNRTLLPNTTLTYDTQKINLY--DSFEASKKACDQLSLGVAAIFGPSHSSSAN 116

  Fly   108 HAMSICDAKELPFLDTRWDFGAQLPT------INLHPHPATLGVALRDMVVALGWESFTIIYESG 166
            ...|||:|..:|.:.|||..  |:..      ::|:|..::|..|:.|:|....|::.|::|:..
Human   117 AVQSICNALGVPHIQTRWKH--QVSDNKDSFYVSLYPDFSSLSRAILDLVQFFKWKTVTVVYDDS 179

  Fly   167 EYLPTVRELLQMYGTAGPTVTVRRYELDLNGNYRNVLRRIRNADDFSFVVVGSMATLPEFFKQAQ 231
            ..|..::||::........:.:|:...|.. :.:.:|:.::...:|..:...|........|||.
Human   180 TGLIRLQELIKAPSRYNLRLKIRQLPADTK-DAKPLLKEMKRGKEFHVIFDCSHEMAAGILKQAL 243

  Fly   232 QVGLVTSDYRYIIGNLDWHTMDLEPYQHAGTNITGLRLVSPDSEQVQEVAKALYESEEPFQNVSC 296
            .:|::|..|.||...||...:|:|||:::|.|:||.|:::.::.||..:.:..  |.|..|....
Human   244 AMGMMTEYYHYIFTTLDLFALDVEPYRYSGVNMTGFRILNTENTQVSSIIEKW--SMERLQAPPK 306

  Fly   297 P--------LTNSMALVYDGVQLLAETYKHVNFRPV-ALSCNDDSAWDKGYTLVNYMKSLTLNGL 352
            |        :|...||:||.|.:::...:......| :|.||....|..|...::.:|.....||
Human   307 PDSGLLDGFMTTDAALMYDAVHVVSVAVQQFPQMTVSSLQCNRHKPWRFGTRFMSLIKEAHWEGL 371

  Fly   353 TGPIRFD-YEGLRTDFKLEVIELAVSGMQKIGQW---SGEDGFQENRPAPAHSLEPDMRSLVNKS 413
            ||.|.|: ..||||||.|:||.|...|::|||.|   ||.:..:..:..||:..:    ||.|:|
Human   372 TGRITFNKTNGLRTDFDLDVISLKEEGLEKIGTWDPASGLNMT
ESQKGKPANITD----SLSNRS 432

  Fly   414 FVVITAISEPYGMLKETSEKLEGNDQFEGFGIELIDELSKKLGFSYTWRLQEDNKYGGIDPKTGE 478
            .:|.|.:.|||.:.|::.:.|.|||:|||:.|:|:.|||..|||:|..||.||.|||..|...|:
Human   433 LIVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEIRLVEDGKYGAQDDANGQ 497

  Fly   479 WNGMLREIIDSRADMGITDLTMTSERESGVDFTIPFMSLGIGILFRKPMKEPPKLFSFMSPFSGE 543
            ||||:||:||.:||:.:..|.:|..||..:||:.|||:|||.||:|||....|.:|||::|.|.:
Human   498 WNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLSPD 562

  Fly   544 VWLWLGLAYMGVSISMFVLGRLSPAEWDNPYPCIEEPTELENQFSFANCLWFSIGALLQQGSELA 608
            :|:::.|||:|||..:||:.|.||.||.||:||..:...:||.|:..|..||.:|||:||||||.
Human   563 IWMYILLAYLGVSCVLFVIARFSPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSELM 627

  Fly   609 PKAYSTRAVAASWWFFTLILVSSYTANLAAFLTVESLVTPINDADDLSKNKGGVNYGAKIGGATF 673
            |||.|||.|...|||||||::||||||||||||||.:.:||:.||||:| :..:.|||...|||.
Human   628 PKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAK-QTKIEYGAVEDGATM 691

  Fly   674 NFFKESNYPTYQRMYEFMRDNPQ-YMTNTNQEGVDRVENSNYAFLMESTTIEYITERRCTLTQVG 737
            .|||:|...||.:|:.||....| .:..:|:||:.||..|:|||||||||||::|:|.|.|||:|
Human   692 TFFKKSKISTYDKMWAFMSSRRQSVLVKSNEEGIQRVLTSDYAFLMESTTIEFVTQRNCNLTQIG 756

  Fly   738 ALLDEKGYGIAMRKNWPYRDTLSQAVLEMQEQGLLTKMKTKWWQEKRGGGACSDADEDSGAVALE 802
            .|:|.||||:......||||.::.|:|::||:|.|..||.|||   ||.| |.: :|...|.||.
Human   757 GLIDSKGYGVGTPMGSPYRDKITIAILQLQEEGKLHMMKEKWW---RGNG-CPE-EESKEASALG 816

  Fly   803 ISNLGGVFLVMGVGSFFGIFVSLLEMVLGVKERSDENQVSFKTELLDEIRFILQCSGNTK 862
            :.|:||:|:|:..|....:||::.|.:...|:.:...:.||.:.:::|:|..|:|....|
Human   817 VQNIGGIFIVLAAGLVLSVFVAVGEFLYKSKKNAQLEKRSFCSAMVEELRMSLKCQRRLK 876

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
GrikNP_001262788.1 PBP1_iGluR_Kainate 37..391 CDD:107377 106/366 (29%)
ANF_receptor 53..374 CDD:279440 96/341 (28%)
Periplasmic_Binding_Protein_Type_2 411..781 CDD:304360 194/370 (52%)
Lig_chan 543..816 CDD:278489 142/273 (52%)
GRIK2NP_068775.1 PBP1_iGluR_Kainate 37..414 CDD:380605 106/366 (29%)
Periplasmic_Binding_Protein_Type_2 430..800 CDD:419667 195/373 (52%)
Glutamate binding. /evidence=ECO:0000250|UniProtKB:P42260 516..518 0/1 (0%)