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Protein Alignment Grik and GRIK1

DIOPT Version :9

Sequence 1:	NP_001262788.1	Gene:	Grik / 42476	FlyBaseID:	FBgn0038840	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	NP_001317923.1	Gene:	GRIK1 / 2897	HGNCID:	4579	Length:	949	Species:	Homo sapiens

Alignment Length:	946	Identity:	337/946 - (35%)
Similarity:	514/946 - (54%)	Gaps:	107/946 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 LLAFPGCRGERTNVGLVY-----------------------ENTDPDLEKI-FHLAISKANEENE 63
            |||.||.....|:..|:|                       ||...::|:: |..|::..|....
Human     6 LLAQPGLWTRDTSWALLYFLCYILPQTAPQVLRIGGIFETVENEPVNVEELAFKFAVTSINRNRT 70

  Fly    64 DLQLHGVSVSIEPGN---SFETSKKLCKMLRQNLVAVFGPTSNLAARHAMSICDAKELPFLDTRW 125
            .:....::..|:..|   |||.|::.|..|...:.|:|||:.:.:.....|||:|.|:|.:.|||
Human    71 LMPNTTLTYDIQRINLFDSFEASRRACDQLALGVAALFGPSHSSSVSAVQSICNALEVPHIQTRW 135

  Fly   126 DF----GAQLPTINLHPHPATLGVALRDMVVALGWESFTIIYESGEYLPTVRELLQMYGTAGPTV 186
            ..    ...|..|||:|..|.:..|:.|:|:...|::.|::||....|..::||::     .|:
Human   136 KHPSVDNKDLFYINLYPDYAAISRAILDLVLYYNWKTVTVVYEDSTGLIRLQELIK-----APS- 194

  Fly   187 TVRRYELDL--------NGNYRNVLRRIRNADDFSFVVVGSMATLPEFFKQAQQVGLVTSDYRYI 243
               ||.:.:        |.:.:.:|:.::...:|..:...|..|..|..||...:|::|..|.|.
Human   195 ---RYNIKIKIRQLPSGNKDAKPLLKEMKKGKEFYVIFDCSHETAAEILKQILFMGMMTEYYHYF 256

  Fly   244 IGNLDWHTMDLEPYQHAGTNITGLRLVSPDSEQVQEVAKALYESEEPFQNVSCP--------LTN 300
            ...||...:|||.|:::|.|:||.||::.|:..|..:.:..  |.|..|....|        :|.
Human   257 FTTLDLFALDLELYRYSGVNMTGFRLLNIDNPHVSSIIEKW--SMERLQAPPRPETGLLDGMMTT 319

  Fly   301 SMALVYDGVQLLA-ETYKHVNFRPVALSCNDDSAWDKGYTLVNYMKSLTLNGLTGPIRFD-YEGL 363
            ..||:||.|.::| .:::.......:|.|:....|..|...:|.:|....:||||.|.|: ..||
Human   320 EAALMYDAVYMVAIASHRASQLTVSSLQCHRHKPWRLGPRFMNLIKEARWDGLTGHITFNKTNGL 384

  Fly   364 RTDFKLEVIELAVSGMQ---------------KIGQWSGEDGF---QENRPAPAHSLEPDMRSLV 410
            |.||.|::|.|...|.:               |||.|:...|.   ..|:...::..:    ||.
Human   385 RKDFDLDIISLKEEGTEKAAGEVSKHLYKVWKKIGIWNSNSGLNMTDSNKDKSSNITD----SLA 445

  Fly   411 NKSFVVITAISEPYGMLKETSEKLEGNDQFEGFGIELIDELSKKLGFSYTWRLQEDNKYGGIDPK 475
            |::.:|.|.:.|||.|.:::.:.|.|||:|||:.::|:.|||..|||.|..:|..|.|||..:.|
Human   446 NRTLIVTTILEEPYVMYRKSDKPLYGNDRFEGYCLDLLKELSNILGFIYDVKLVPDGKYGAQNDK 510

  Fly   476 TGEWNGMLREIIDSRADMGITDLTMTSERESGVDFTIPFMSLGIGILFRKPMKEPPKLFSFMSPF 540
             ||||||::|:||.|||:.:..||:|..||..:||:.|||:|||.||:|||....|.:|||::|.
Human   511 -GEWNGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPL 574

  Fly   541 SGEVWLWLGLAYMGVSISMFVLGRLSPAEWDNPYPCIEEPTELENQFSFANCLWFSIGALLQQGS 605
            |.::|:::.||.:|||..:||:.|.:|.||.||:||..:...:||.|:..|..||.:|||:||||
Human   575 SPDIWMYVLLACLGVSCVLFVIARFTPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGS 639

  Fly   606 ELAPKAYSTRAVAASWWFFTLILVSSYTANLAAFLTVESLVTPINDADDLSKNKGGVNYGAKIGG 670
            ||.|||.|||.|...|||||||::||||||||||||||.:.:||:.||||:| :..:.|||...|
Human   640 ELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAK-QTKIEYGAVRDG 703

  Fly   671 ATFNFFKESNYPTYQRMYEFMRDNPQ-YMTNTNQEGVDRVENSNYAFLMESTTIEYITERRCTLT 734
            :|..|||:|...||::|:.||....| .:...:.||:.||..::||.|||||:|||:|:|.|.||
Human   704 STMTFFKKSKISTYEKMWAFMSSRQQTALVRNSDEGIQRVLTTDYALLMESTSIEYVTQRNCNLT 768

  Fly   735 QVGALLDEKGYGIAMRKNWPYRDTLSQAVLEMQEQGLLTKMKTKWWQEKRGGGACSDADEDSGAV 799
            |:|.|:|.||||:......||||.::.|:|::||:|.|..||.|||   ||.| |.:.| :..|.
Human   769 QIGGLIDSKGYGVGTPIGSPYRDKITIAILQLQEEGKLHMMKEKWW---RGNG-CPEED-NKEAS 828

  Fly   800 ALEISNLGGVFLVMGVGSFFGIFVSLLEMVLGVKERSDENQVSFKTEL----LDEIRF---ILQC 857
            ||.:.|:||:|:|:..|....:||::.|.:...::.:|..|....:.:    .:::||   ..|.
Human   829 ALGVENIGGIFIVLAAGLVLSVFVAIGEFIYKSRKNNDIEQKGKSSRIRFYFRNKVRFHGRKKQS 893

  Fly   858 SGNTKAVKYP----------KNSSRSNASSKSKGSS 883
            .|..|.:.:.          ||..:....|::||.|
Human   894 LGVEKCLSFNAIMEELGISLKNQKKIKKKSRTKGKS 929

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.