Protein Alignment Grik and GRID2

DIOPT Version :10

• Sequence 1: NP_001262788.1
• Gene: Grik / 42476
• FlyBaseID: FBgn0038840
• Length: 907
• Species: Drosophila melanogaster
• Sequence 2: XP_011530195.2
• Gene: GRID2 / 2895
• HGNCID: 4576
• Length: 1035
• Species: Homo sapiens
• Alignment Length: 872
• Identity: 233/872 - (26%)
• Similarity: 407/872 - (46%)
• Gaps: 137/872 - (15%)

  Fly    66 QLHGVSVSIEPGNSFETSKKLCKMLRQNLVAVFGPTSNLAARHAMSICDAKELPFL--------- 121
            :..|.:.:..|..:.  .:|.|:::.|.::|:.......:|....|:.||..:|.|
Human    76 ETRGTNTTASPATAL--PQKTCELMNQGILALVSSIGCTSAGSLQSLADAMHIPHLFIQRSTAGT 138

  Fly   122 ----------DTRWDFGAQLPTINLHPHPATLGVALRDMVVALGWESFTIIYESGEYLPTVRELL 176
                      :...|:     |:::.| |..|...:..:|....|:.|.|.|:|...:..::|.|
Human   139 PRSGCGLTRSNRNDDY-----TLSVRP-PVYLHDVILRVVTEYAWQKFIIFYDSEYDIRGIQEFL 197

  Fly   177 QMYGTAGPTVTVRRYELDLN---------------GNYRNVLRRIRNADDFSFVVVGSMATLPEF 226
            ......|..|.:::.|.::|               ..||:.|||.        ::|.:.||...|
Human   198 DKVSQQGMDVALQKVENNINKMITTLFDTMRIEELNRYRDTLRRA--------ILVMNPATAKSF 254

  Fly   227 FKQAQQVGLVTSDYRYIIGNLDWHTMDL-EPYQHAGTNITGLRLVSPDSEQVQE--------VAK 282
            ..:..:..||..|..:||.|.:.:.:|: |..:.:...:|.:|...|..:.:.:        ::.
Human   255 ITEVVETNLVAFDCHWIIINEEINDVDVQELVRRSIGRLTIIRQTFPVPQNISQRCFRGNHRISS 319

  Fly   283 ALYESEEPF-QNVSCPLTNSMALVYDGVQLLAETY-KHVNFRP----VALSC--NDDSAWDKGYT 339
            .|.:.::|| ||:..    |...:||.|.|||..: |.:..|.    .:|||  .:...|..|.:
Human   320 TLCDPKDPFAQNMEI----SNLYIYDTVLLLANAFHKKLEDRKWHSMASLSCIRKNSKPWQGGRS 380

  Fly   340 LVNYMKSLTLNGLTGPIRFDYEGLRTDFKLEVI------ELAVSGMQK----------------I 382
            ::..:|...::||||.:.|...|...:...|::      ||. .|::|                :
Human   381 MLETIKKGGVSGLTGELEFGENGGNPNVHFEILGTNYGEELG-RGVRKNERIRPQGSTGKIWPQL 444

  Fly   383 GQWSGEDGFQENRPAPAHSLEPDMRSLVNKSFVVITAISEPYGMLKETSEKLEGN-DQFEGFGIE 446
            |.|:...|.  |.......||.:||.:|.:   |:|.:.||:.|:   ||.:.|. .:::||.|:
Human   445 GCWNPVTGL--NGSLTDKKLENNMRGVVLR---VVTVLEEPFVMV---SENVLGKPKKYQGFSID 501

  Fly   447 LIDELSKKLGFSYTWRLQEDNKYGGIDPKTGEWNGMLREIIDSRADMGITDLTMTSERESGVDFT 511
            ::|.||..|||:|...:..|:|||. ..:.|.|||::.|::..|||:||:.||:|.:||:.||||
Human   502 VLDALSNYLGFNYEIYVAPDHKYGS-PQEDGTWNGLVGELVFKRADIGISALTITPDRENVVDFT 565

  Fly   512 IPFMSLGIGILFRKPMKEPPKLFSFMSPFSGEVWLWLGLAYMGVSISMFVLGRLSPAEWDNPYPC 576
            ..:|...:|:|.|:..| ...:|:.::||...:|..:....:.|.:.:::|      .|.|| |.
Human   566 TRYMDYSVGVLLRRAEK-TVDMFACLAPFDLSLWACIAGTVLLVGLLVYLL------NWLNP-PR 622

  Fly   577 IEEPTELENQFSFANCLWFSIGALLQQGSELAPKAYSTRAVAASWWFFTLILVSSYTANLAAFLT 641
            ::..:....  :..|.:||..|:.:|||.|:.....:||.:..:||.|.||::||||||||||||
Human   623 LQMGSMTST--TLYNSMWFVYGSFVQQGGEVPYTTLATRMMMGAWWLFALIVISSYTANLAAFLT 685

  Fly   642 VESLVTPINDADDLSKNKGGVNYGAKIGGATFNFFKESNYPTYQR--MYEFM-----RDN-PQYM 698
            :..:.:.|....|||| :..:.||..:..|.:...:......::|  ||..|     |.| .:..
Human   686 ITRIESSIQSLQDLSK-QTEIPYGTVLDSAVYEHVRMKGLNPFERDSMYSQMWRMINRSNGSENN 749

  Fly   699 TNTNQEGVDRVENSNYAFLMESTTIEY--ITERRCTLTQVGALLDEKGYGIAMRKNWPYRDTLSQ 761
            ...:|.|:.:|:..||||:.::..:||  |.:..|:...:|..:.::|||||::...||||..||
Human   750 VLESQAGIQKVKYGNYAFVWDAAVLEYVAINDPDCSFYTIGNTVADRGYGIALQHGSPYRDVFSQ 814

  Fly   762 AVLEMQEQGLLTKMKTKWWQEKRGGGAC---SDADEDSGAVALEISNLGGVFLVMGVGSFFGIFV 823
            .:||:|:.|.:..:|.|||.:   .|.|   |..|......||:|.:..|||.::..|.....|:
Human   815 RILELQQNGDMDILKHKWWPK---NGQCDLYSSVDTKQKGGALDIKSFAGVFCILAAGIVLSCFI 876

  Fly   824 SLLEMVLG------VKERSDENQVSFK 844
            ::||....      |..:.|:.::..:
Human   877 AMLETWWNKRKGSRVPSKEDDKEIDLE 903

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Grik	NP_001262788.1	PBP1_iGluR_Kainate	35..395	CDD:380605	83/401 (21%)
		Periplasmic_Binding_Protein_Type_2	411..781	CDD:473866	127/380 (33%)
GRID2	XP_011530195.2	Periplasmic_Binding_Protein_type1	92..457	CDD:471960	82/385 (21%)
		PBP2_iGluR_delta_2	468..834	CDD:270449	128/383 (33%)