DRSC/TRiP Functional Genomics Resources

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Protein Alignment Grik and GRIA3

DIOPT Version :9

Sequence 1:NP_001262788.1 Gene:Grik / 42476 FlyBaseID:FBgn0038840 Length:907 Species:Drosophila melanogaster
Sequence 2:NP_000819.4 Gene:GRIA3 / 2892 HGNCID:4573 Length:894 Species:Homo sapiens


Alignment Length:876 Identity:284/876 - (32%)
Similarity:457/876 - (52%) Gaps:82/876 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly    39 VYENTDPDLEKIFHLAISKANEENEDLQLHGVSVSIEPGNSFETSKKLCKMLRQNLVAVFGPTSN 103
            :|.......||.|||     |...:.|         :..|||..:...|....:.:.|:||....
Human    57 LYNTNQNTTEKPFHL-----NYHVDHL---------DSSNSFSVTNAFCSQFSRGVYAIFGFYDQ 107

  Fly   104 LAARHAMSICDAKELPFLDTRWDFGAQLPTINLHPHPATLGVALRDMVVALGWESFTIIYESGEY 168
            ::.....|.|.|....|:...:...|.:..: :...||..| |:..::....||.|..:|::...
Human   108 MSMNTLTSFCGALHTSFVTPSFPTDADVQFV-IQMRPALKG-AILSLLGHYKWEKFVYLYDTERG 170

  Fly   169 LPTVRELLQMYGTAGPTVTVRRYELDLNGN------YRNVLRRIRNADDFSFVVVGSMATLPEFF 227
            ...::.:::........||.|..     ||      :|.::..:....:..:::...:..:....
Human   171 FSILQAIMEAAVQNNWQVTARSV-----GNIKDVQEFRRIIEEMDRRQEKRYLIDCEVERINTIL 230

  Fly   228 KQAQQVGLVTSDYRYIIGNLDWHTMDLEPYQHAGTNITGLRLVSPDSEQVQEVAK---ALYESEE 289
            :|...:|..:..|.|::.||.:..:.||...|.|.||||.::|:.::..||:..:   .|.|.|.
Human   231 EQVVILGKHSRGYHYMLANLGFTDILLERVMHGGANITGFQIVNNENPMVQQFIQRWVRLDEREF 295

  Fly   290 PFQNVSCPLTNSMALVYDGVQLLAETYKHVNFRPVALS---------CNDDSAWDKGYTLVNYMK 345
            | :..:.||..:.||.:|.:.::||.::::..:.|.:|         .|....|.:|..:...:|
Human   296 P-EAKNAPLKYTSALTHDAILVIAEAFRYLRRQRVDVSRRGSAGDCLANPAVPWSQGIDIERALK 359

  Fly   346 SLTLNGLTGPIRFDYEGLRTDFKLEVIELAVSGMQKIGQWSGEDGFQENRPAPAHSLEPDMRSLV 410
            .:.:.|:||.|:||..|.||::.::|.|:.|||.:|.|.|:..:.|.   |.....:..|..|..
Human   360 MVQVQGMTGNIQFDTYGRRTNYTIDVYEMKVSGSRKAGYWNEYERFV---PFSDQQISNDSASSE 421

  Fly   411 NKSFVVITAISEPYGMLKETSEKLEGNDQFEGFGIELIDELSKKLGFSYTWRLQEDNKYGGIDPK 475
            |::.||.|.:..||.|.|:..|:||||:::||:.::|..|::|.:...|...:..|.|||..||:
Human   422 NRTIVVTTILESPYVMYKKNHEQLEGNERYEGYCVDLAYEIAKHVRIKYKLSIVGDGKYGARDPE 486

  Fly   476 TGEWNGMLREIIDSRADMGITDLTMTSERESGVDFTIPFMSLGIGILFRKPMKEPPKLFSFMSPF 540
            |..||||:.|::..|||:.:..||:|..||..:||:.|||||||.|:.:||.|..|.:|||:.|.
Human   487 TKIWNGMVGELVYGRADIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPL 551

  Fly   541 SGEVWLWLGLAYMGVSISMFVLGRLSPAEW---DNPYPCIEEPTELE------NQFSFANCLWFS 596
            :.|:|:.:..||:|||:.:|::.|.||.||   ||.    |||.:.:      |:|...|.||||
Human   552 AYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHLEDNN----EEPRDPQSPPDPPNEFGIFNSLWFS 612

  Fly   597 IGALLQQGSELAPKAYSTRAVAASWWFFTLILVSSYTANLAAFLTVESLVTPINDADDLSKNKGG 661
            :||.:|||.:::|::.|.|.|...|||||||::||||||||||||||.:|:||..|:||:| :..
Human   613 LGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAK-QTE 676

  Fly   662 VNYGAKIGGATFNFFKESNYPTYQRMYEFMRD-NPQYMTNTNQEGVDRVENS--NYAFLMESTTI 723
            :.||....|:|..||:.|....|::|:.:|:. .|...|.|..:||.||..|  .:|||:|||..
Human   677 IAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKSAEPSVFTKTTADGVARVRKSKGKFAFLLESTMN 741

  Fly   724 EYITERR-CTLTQVGALLDEKGYGIAMRKNWPYRDTLSQAVLEMQEQGLLTKMKTKWWQEKRGGG 787
            |||.:|: |...:||..||.||||:|..|....|:.::.|||::.|||||.|:|.|||.:|   |
Human   742 EYIEQRKPCDTMKVGGNLDSKGYGVATPKGSALRNAVNLAVLKLNEQGLLDKLKNKWWYDK---G 803

  Fly   788 ACSDADEDS--GAVALEISNLGGVFLVMGVGSFFGIFVSLLEMVLGVKERSDENQVSFKTELLDE 850
            .|.....||  ...||.:||:.|||.::..|....:.|:|:|..  .|.|::..:          
Human   804 ECGSGGGDSKDKTSALSLSNVAGVFYILVGGLGLAMMVALIEFC--YKSRAESKR---------- 856

  Fly   851 IRFILQCSGNTKAVKYPKNSSRSNASSKSKG 881
                ::.:.||:..|....::..|.::..:|
Human   857 ----MKLTKNTQNFKPAPATNTQNYATYREG 883

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
GrikNP_001262788.1 PBP1_iGluR_Kainate 37..391 CDD:107377 85/369 (23%)
ANF_receptor 53..374 CDD:279440 73/338 (22%)
Periplasmic_Binding_Protein_Type_2 411..781 CDD:304360 171/382 (45%)
Lig_chan 543..816 CDD:278489 127/287 (44%)
GRIA3NP_000819.4 PBP1_iGluR_AMPA_GluR3 35..409 CDD:380610 87/376 (23%)
PBP2_iGluR_AMPA 422..805 CDD:270433 174/390 (45%)
Glutamate binding. /evidence=ECO:0000250 508..510 0/1 (0%)