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Protein Alignment Grik and GRIA2

DIOPT Version :9

Sequence 1:	NP_001262788.1	Gene:	Grik / 42476	FlyBaseID:	FBgn0038840	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	NP_000817.5	Gene:	GRIA2 / 2891	HGNCID:	4572	Length:	883	Species:	Homo sapiens

Alignment Length:	858	Identity:	280/858 - (32%)
Similarity:	434/858 - (50%)	Gaps:	99/858 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 SIEPGNSFETSKKLCKMLRQNLVAVFGPTSNLAARHAMSICDAKELPFLDTRWDFGAQLPTINLH 137
            ::|..|||..:...|....:.:.|:||.....:.....|.|....:.|:.      ...||...|
Human    64 NLEVANSFAVTNAFCSQFSRGVYAIFGFYDKKSVNTITSFCGTLHVSFIT------PSFPTDGTH 122

  Fly   138 P-----HPATLGVALRDMVVALGWESFTIIYESGEYLPTVRELLQMYGTAGPTVTVRRYEL---- 193
            |     .|...| ||..::....|:.|..:|:|...|.|::.:|.       :...:::::
Human   123 PFVIQMRPDLKG-ALLSLIEYYQWDKFAYLYDSDRGLSTLQAVLD-------SAAEKKWQVTAIN 179

  Fly   194 --DLNGN-----YRNVLRRIRNADDFSFVVVGSMATLPEFFKQAQQVGLVTSDYRYIIGNLDWHT 251
              ::|.:     ||::.:.:....:...::......:.:...|...:|.....|.|||.||.:..
Human   180 VGNINNDKKDEMYRSLFQDLELKKERRVILDCERDKVNDIVDQVITIGKHVKGYHYIIANLGFTD 244

  Fly   252 MDLEPYQHAGTNITGLRLVSPDSEQVQEVAK---ALYESEEPFQNVSCPLTNSMALVYDGVQLLA 313
            .||...|..|.|::|.::|..|...|.:..:   .|.|.|.|..:.: .:..:.||.||.||::.
Human   245 GDLLKIQFGGANVSGFQIVDYDDSLVSKFIERWSTLEEKEYPGAHTT-TIKYTSALTYDAVQVMT 308

  Fly   314 ETYKHVNFRPVALS---------CNDDSAWDKGYTLVNYMKSLTLNGLTGPIRFDYEGLRTDFKL 369
            |.::::..:.:.:|         .|....|.:|..:...:|.:.:.||:|.|:||..|.|.::.:
Human   309 EAFRNLRKQRIEISRRGNAGDCLANPAVPWGQGVEIERALKQVQVEGLSGNIKFDQNGKRINYTI 373

  Fly   370 EVIELAVSGMQKIGQWSGEDGFQEN-RPAPAHSLEPDMRSLVNKSFVVITAISEPYGMLKETSEK 433
            .::||..:|.:|||.||..|..... ...|:.:   |...|.||:.||.|.:..||.|:|:..|.
Human   374 NIMELKTNGPRKIGYWSEVDKMVVTLTELPSGN---DTSGLENKTVVVTTILESPYVMMKKNHEM 435

  Fly   434 LEGNDQFEGFGIELIDELSKKLGFSYTWRLQEDNKYGGIDPKTGEWNGMLREIIDSRADMGITDL 498
            ||||:::||:.::|..|::|..||.|...:..|.|||..|..|..||||:.|::..:||:.|..|
Human   436 LEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPL 500

  Fly   499 TMTSERESGVDFTIPFMSLGIGILFRKPMKEPPKLFSFMSPFSGEVWLWLGLAYMGVSISMFVLG 563
            |:|..||..:||:.|||||||.|:.:||.|..|.:|||:.|.:.|:|:.:..||:|||:.:|::.
Human   501 TITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVS 565

  Fly   564 RLSPAEWDNPYPCIEE--------PTELENQFSFANCLWFSIGALLQQGSELAPKAYSTRAVAAS 620
            |.||.||..     ||        .:|..|:|...|.||||:||.:|||.:::|::.|.|.|...
Human   566 RFSPYEWHT-----EEFEDGRETQSSESTNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGV 625

  Fly   621 WWFFTLILVSSYTANLAAFLTVESLVTPINDADDLSKNKGGVNYGAKIGGATFNFFKESNYPTYQ 685
            |||||||::||||||||||||||.:|:||..|:|||| :..:.||....|:|..||:.|....:.
Human   626 WWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLSK-QTEIAYGTLDSGSTKEFFRRSKIAVFD 689

  Fly   686 RMYEFMRD-NPQYMTNTNQEGVDRVENS--NYAFLMESTTIEYITERR-CTLTQVGALLDEKGYG 746
            :|:.:||. .|.....|..|||.||..|  .||:|:|||..|||.:|: |...:||..||.||||
Human   690 KMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYG 754

  Fly   747 IAMRKNWPYRDTLSQAVLEMQEQGLLTKMKTKWWQEKRGGGACSDADEDSGA----VALEISNLG 807
            ||..|....|..::.|||::.|||:|.|:|.|||.:|...||     :|||:    .||.:||:.
Human   755 IATPKGSSLRTPVNLAVLKLSEQGVLDKLKNKWWYDKGECGA-----KDSGSKEKTSALSLSNVA 814

  Fly   808 GVFLVMGVGSFFGIFVSLLEMVLGVKERSDENQVSFKTELLDEIRFILQCSGNTKAVKYPKNSSR 872
            |||.::..|....:.|:|:|                         |..:.....|.:|..||:..
Human   815 GVFYILVGGLGLAMLVALIE-------------------------FCYKSRAEAKRMKVAKNAQN 854

  Fly   873 SNASSKSKGSSMS 885
            .|.||.....:.:
Human   855 INPSSSQNSQNFA 867

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.