Protein Alignment Grik and Grin2d

DIOPT Version :10

• Sequence 1: NP_001262788.1
• Gene: Grik / 42476
• FlyBaseID: FBgn0038840
• Length: 907
• Species: Drosophila melanogaster
• Sequence 2: XP_063136781.1
• Gene: Grin2d / 24412
• RGDID: 2740
• Length: 1356
• Species: Rattus norvegicus
• Alignment Length: 906
• Identity: 200/906 - (22%)
• Similarity: 335/906 - (36%)
• Gaps: 234/906 - (25%)

  Fly    93 NLVAVF-GPT-SNLAARHAMSICDAKELPFLDTRWDFGAQLPTINLHPHPATL---GVALRDMVV 152
            |:..|| ||. :..|||...::..|...|.||.|               |..|   |...|.:|:
  Rat    49 NVALVFSGPAYAAEAARLGPAVAAAVRSPGLDVR---------------PVALVLNGSDPRSLVL 98

  Fly   153 AL-----GWESFTIIYESGEYLPTVRELLQMYG--TAGPTVTVRRYELDLNGNYRNVLRRIRNAD 210
            .|     |.....:::|.....|.|..:|....  |:.|.|.|       :|....||.......
  Rat    99 QLCDLLSGLRVHGVVFEDDSRAPAVAPILDFLSAQTSLPIVAV-------HGGAALVLTPKEKGS 156

  Fly   211 DFSFVVVGSMATLPEFFKQAQQVGLVTSDYRYIIGNLDWHTM----------------------- 252
              :|:.:||...     :|.|.:..|..:|       ||.:.
  Rat   157 --TFLQLGSSTE-----QQLQVIFEVLEEY-------DWTSFVAVTTRAPGHRAFLSYIEVLTDG 207

  Fly   253 DLEPYQH---------AGTNITG---------LRLVSPDSEQVQEVAKALYES------------ 287
            .|..::|         ||..:.|         :||:....|:.:.|.:|..|:
  Rat   208 SLVGWEHRGALTLDPGAGEAVLGAQLRSVSAQIRLLFCAREEAEPVFRAAEEAGLTGPGYVWFMV 272

  Fly   288 -------------EEPF---------------------QNVSCPLTNSMALVYDGVQLLAETYKH 318
                         .||.                     .:::..:...:|:|..|.|.|...|
  Rat   273 GPQLAGGGGSGVPGEPLLLPGGSPLPAGLFAVRSAGWRDDLARRVAAGVAVVARGAQALLRDY-- 335

  Fly   319 VNFRP-VALSCNDDSAWDKGYTLVNYMKSLTLNGLTGPIRFDYEGLRTDFKLEVIELAVS-GMQK 381
             .|.| :...|...:...:|.:|..|..::|.:  .....|:.:|...:..|.||.|... ..:.
  Rat   336 -GFLPELGHDCRTQNRTHRGESLHRYFMNITWD--NRDYSFNEDGFLVNPSLVVISLTRDRTWEV 397

  Fly   382 IGQWSGEDGFQENRP---APAHSLEP-------DMRSLVNKSFVVITAISEPYGMLKET--SEKL 434
            :|.|. :...:...|   .....|:|       .:.:|..:.||::    ||...:..|  .:.:
  Rat   398 VGSWE-QQTLRLKYPLWSRYGRFLQPVDDTQHLTVATLEERPFVIV----EPADPISGTCIRDSV 457

  Fly   435 EGNDQF------------------EGFGIELIDELSKKLGFSYTWRLQEDNKYG-GIDPKTGEWN 480
            ....|.                  :||.|:::..|:..:||||...|..:.|:| .||   |.||
  Rat   458 PCRSQLNRTHSPPPDAPRPEKRCCKGFCIDILKRLAHTIGFSYDLYLVTNGKHGKKID---GVWN 519

  Fly   481 GMLREIIDSRADMGITDLTMTSERESGVDFTIPFMSLGIGILF-RKPMKEPPKLFSFMSPFSGEV 544
            ||:.|:...||||.|..||:..||...|||::||:..||.::. |......|.  :|:.|:|..|
  Rat   520 GMIGEVFYQRADMAIGSLTINEERSEIVDFSVPFVETGISVMVARSNGTVSPS--AFLEPYSPAV 582

  Fly   545 WLWLGLAYMG-VSISMFVLGRLSPAEWDNPYPCIEEPTELENQFSFANCLWFSIGALLQQGSELA 608
            |:.:.:..:. |::::|:...|||..::......:.|.  .:.|:....:|. :.||:...|...
  Rat   583 WVMMFVMCLTVVAVTVFIFEYLSPVGYNRSLATGKRPG--GSTFTIGKSIWL-LWALVFNNSVPV 644

  Fly   609 --PKAYSTRAVAASWWFFTLILVSSYTANLAAFLTVESLVTPINDADDLSKNKGGVNY-----GA 666
              |:..:::.:...|.||.:|.::|||||||||:..|..|..::...|....:....|     |.
  Rat   645 ENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEEYVDTVSGLSDRKFQRPQEQYPPLKFGT 709

  Fly   667 KIGGATFNFFKESNYPTYQRMYEFMRDNPQYMTNTNQEGVDRVENSNY--------AFLMESTTI 723
            ...|:|....: ||||          |...||...||   .|||.:..        ||:.::..:
  Rat   710 VPNGSTEKNIR-SNYP----------DMHSYMVRYNQ---PRVEEALTQLKAGKLDAFIYDAAVL 760

  Fly   724 EYIT--ERRCTLTQVGA--LLDEKGYGIAMRKNWPYRDTLSQAVLEMQEQGLLTKMKTKWWQEKR 784
            .|:.  :..|.|..:|:  :....|||||:.|...::..:..|:|:......:..::..|.
  Rat   761 NYMARKDEGCKLVTIGSGKVFATTGYGIALHKGSRWKRPIDLALLQFLGDDEIEMLERLWL---- 821

  Fly   785 GGGACSDADEDSGAVALEISNLGGVFLVMGVGSFFGIFVSLLEMV--------LGVKERSD 837
             .|.|.:...:..:..|:|.|:.|||.::.|.....:.|...|.:        ||...|.|
  Rat   822 -SGICHNDKIEVMSSKLDIDNMAGVFYMLLVAMGLSLLVFAWEHLVYWRLRHCLGPTHRMD 881

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Grik	NP_001262788.1	PBP1_iGluR_Kainate	35..395	CDD:380605	74/402 (18%)
		Periplasmic_Binding_Protein_Type_2	411..781	CDD:473866	107/411 (26%)
Grin2d	XP_063136781.1	None