Protein Alignment Grik and Grin2b

DIOPT Version :10

• Sequence 1: NP_001262788.1
• Gene: Grik / 42476
• FlyBaseID: FBgn0038840
• Length: 907
• Species: Drosophila melanogaster
• Sequence 2: NP_036706.1
• Gene: Grin2b / 24410
• RGDID: 2738
• Length: 1482
• Species: Rattus norvegicus
• Alignment Length: 1044
• Identity: 218/1044 - (20%)
• Similarity: 402/1044 - (38%)
• Gaps: 245/1044 - (23%)

  Fly     8 STEASFPLGFILTSLLLAFPG--CRGERT----NVGLVYENTDPDLEKIFHLAISKANEENEDLQ 66
            |.|...| .|.|...:||..|  .|.:::    .:.::...|..:      :||..|:|:::
  Rat     4 SAECCSP-KFWLVLAVLAVSGSKARSQKSPPSIGIAVILVGTSDE------VAIKDAHEKDD--- 58

  Fly    67 LHGVSV--SIEPGNSFETSKK-----LCKMLRQNLV--AVFGPTSNLAARHAMSICDAKELPFLD 122
            .|.:||  .:|.....||..|     :|.::....:  .||...::..|       .|:.|.|:.
  Rat    59 FHHLSVVPRVELVAMNETDPKSIITRICDLMSDRKIQGVVFADDTDQEA-------IAQILDFIS 116

  Fly   123 TRWDFGAQLPTINLH--------------------PHPATLGVALRDMVVALGWESFTII--YES 165
            .:    ...|.:.:|                    |........:.:::....|..|:|:  |..
  Rat   117 AQ----TLTPILGIHGGSSMIMADKDESSMFFQFGPSIEQQASVMLNIMEEYDWYIFSIVTTYFP 177

  Fly   166 G--EYLPTVRELLQMYGTAGPTVTVRRYELDL---NGNYRNVLRRIRNADDFSFVVVGSMATLPE 225
            |  :::..:|..::..........|...::.|   :...:|.|:::::.      ::....|..|
  Rat   178 GYQDFVNKIRSTIENSFVGWELEEVLLLDMSLDDGDSKIQNQLKKLQSP------IILLYCTKEE 236

  Fly   226 ---FFKQAQQVGLVTSDYRYIIGNLDWHTMDLEPYQHAGTNITGLRLVSPDSEQVQEVAKALYES 287
               .|:.|..|||....|.:|:.:|.....|..|.:..    |||..||.|.
  Rat   237 ATYIFEVANSVGLTGYGYTWIVPSLVAGDTDTVPSEFP----TGLISVSYDE------------- 284

  Fly   288 EEPFQNVSCPLTNSMALVYDGVQLL----AETYKHVNFRPVALSCNDDSAWDKGY---TLVNYMK 345
                .:...|     |.|.||:.::    ::.....:|.|...|...::...:.|   .|..|:.
  Rat   285 ----WDYGLP-----ARVRDGIAIITTAASDMLSEHSFIPEPKSSCYNTHEKRIYQSNMLNRYLI 340

  Fly   346 SLTLNGLTGPIRFDYEGLRTDFKLEVIEL-AVSGMQKIGQWSGEDGFQEN-----RPAP-AHSLE 403
            ::|..|..  :.|..:|.:...||.:|.| .....:::|:|. :...|..     |..| ....|
  Rat   341 NVTFEGRN--LSFSEDGYQMHPKLVIILLNKERKWERVGKWK-DKSLQMKYYVWPRMCPETEEQE 402

  Fly   404 PDMRSLV---NKSFVVITAI-------------------------SEPYGMLKETSEKLEGNDQF 440
            .|..|:|   ...||::.::                         .|| |.:|:..
  Rat   403 DDHLSIVTLEEAPFVIVESVDPLSGTCMRNTVPCQKRIISENKTDEEP-GYIKKCC--------- 457

  Fly   441 EGFGIELIDELSKKLGFSYTWRLQEDNKYGGIDPKTGEWNGMLREIIDSRADMGITDLTMTSERE 505
            :||.|:::.::||.:.|:|...|..:.|:|  ....|.||||:.|::..||.|.:..||:..||.
  Rat   458 KGFCIDILKKISKSVKFTYDLYLVTNGKHG--KKINGTWNGMIGEVVMKRAYMAVGSLTINEERS 520

  Fly   506 SGVDFTIPFMSLGIGILF-RKPMKEPPKLFSFMSPFSGEVWLWLGLAYMGVS-ISMFVLGRLSPA 568
            ..|||::||:..||.::. |......|.  :|:.|||.:||:.:.:..:.|| :::||....||.
  Rat   521 EVVDFSVPFIETGISVMVSRSNGTVSPS--AFLEPFSADVWVMMFVMLLIVSAVAVFVFEYFSPV 583

  Fly   569 EWDNPYPCIEEPTELEN-QFSFANCLWFSIGALLQQGSELA-PKAYSTRAVAASWWFFTLILVSS 631
            .::.   |:.:..|... .|:....:|...|.:......:. ||..:::.:.:.|.||.:|.::|
  Rat   584 GYNR---CLADGREPGGPSFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLAS 645

  Fly   632 YTANLAAFLTVESLVTPINDADDLSKNKGG-----VNYGAKIGGATFNFFKESNYPTYQRMYEFM 691
            ||||||||:..|..|..::...|....:..     ..:|....|:|....:.:    |..|:
  Rat   646 YTANLAAFMIQEEYVDQVSGLSDKKFQRPNDFSPPFRFGTVPNGSTERNIRNN----YAEMH--- 703

  Fly   692 RDNPQYMTNTNQEGVD---------RVENSNYAFLMESTTIEYITER--RCTLTQVGA--LLDEK 743
                .||...||.|||         :::    ||:.::..:.|:..|  .|.|..:|:  :....
  Rat   704 ----AYMGKFNQRGVDDALLSLKTGKLD----AFIYDAAVLNYMAGRDEGCKLVTIGSGKVFAST 760

  Fly   744 GYGIAMRKNWPYRDTLSQAVLEMQEQGLLTKMKTKWWQEKRGGGACSDADEDSGAVALEISNLGG 808
            |||||::|:..::..:..|:|::...|.:.:::..|..     |.|.:...:..:..|:|.|:.|
  Rat   761 GYGIAIQKDSGWKRQVDLAILQLFGDGEMEELEALWLT-----GICHNEKNEVMSSQLDIDNMAG 820

  Fly   809 VFLVMGV-------------------------------GSFFGIFVSLLEMVLGVKERSDENQVS 842
            ||.::|.                               |..|.|...:...:.||.....::.::
  Rat   821 VFYMLGAAMALSLITFICEHLFYWQFRHCFMGVCSGKPGMVFSISRGIYSCIHGVAIEERQSVMN 885

  Fly   843 FKTELLDE-----IRFILQCSGNTKAVKYPKNSSRSNASSKSKGSSMSVDSLPEDTSEADASGKH 902
            ..|..::.     :|.:       :..|...|.|..|.|.:|....:..:|...|.||...|..|
  Rat   886 SPTATMNNTHSNILRLL-------RTAKNMANLSGVNGSPQSALDFIRRESSVYDISEHRRSFTH 943

  Fly   903 NHGK 906
            :..|
  Rat   944 SDCK 947

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Grik	NP_001262788.1	PBP1_iGluR_Kainate	35..395	CDD:380605	72/411 (18%)
		Periplasmic_Binding_Protein_Type_2	411..781	CDD:473866	102/416 (25%)
Grin2b	NP_036706.1	PBP1_iGluR_NMDA_NR2	33..388	CDD:380601	72/409 (18%)
		PBP2_iGluR_NMDA_Nr2	403..803	CDD:270436	107/436 (25%)
		Pore-forming. /evidence=ECO:0000269|PubMed:24876489, ECO:0000305|PubMed:24876489	604..623		2/18 (11%)
		NMDAR2_C	840..1482	CDD:463148	20/115 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1161..1194
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1269..1301
		Interaction with DAPK1. /evidence=ECO:0000250|UniProtKB:Q01097	1292..1304
		PDZ-binding	1480..1482