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Protein Alignment Grik and Grin2b

DIOPT Version :9

Sequence 1:	NP_001262788.1	Gene:	Grik / 42476	FlyBaseID:	FBgn0038840	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	NP_036706.1	Gene:	Grin2b / 24410	RGDID:	2738	Length:	1482	Species:	Rattus norvegicus

Alignment Length:	1044	Identity:	218/1044 - (20%)
Similarity:	402/1044 - (38%)	Gaps:	245/1044 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 STEASFPLGFILTSLLLAFPG--CRGERT----NVGLVYENTDPDLEKIFHLAISKANEENEDLQ 66
            |.|...| .|.|...:||..|  .|.:::    .:.::...|..:      :||..|:|:::
  Rat     4 SAECCSP-KFWLVLAVLAVSGSKARSQKSPPSIGIAVILVGTSDE------VAIKDAHEKDD--- 58

  Fly    67 LHGVSV--SIEPGNSFETSKK-----LCKMLRQNLV--AVFGPTSNLAARHAMSICDAKELPFLD 122
            .|.:||  .:|.....||..|     :|.::....:  .||...::..|       .|:.|.|:.
  Rat    59 FHHLSVVPRVELVAMNETDPKSIITRICDLMSDRKIQGVVFADDTDQEA-------IAQILDFIS 116

  Fly   123 TRWDFGAQLPTINLH--------------------PHPATLGVALRDMVVALGWESFTII--YES 165
            .:    ...|.:.:|                    |........:.:::....|..|:|:  |..
  Rat   117 AQ----TLTPILGIHGGSSMIMADKDESSMFFQFGPSIEQQASVMLNIMEEYDWYIFSIVTTYFP 177

  Fly   166 G--EYLPTVRELLQMYGTAGPTVTVRRYELDL---NGNYRNVLRRIRNADDFSFVVVGSMATLPE 225
            |  :::..:|..::..........|...::.|   :...:|.|:::::.      ::....|..|
  Rat   178 GYQDFVNKIRSTIENSFVGWELEEVLLLDMSLDDGDSKIQNQLKKLQSP------IILLYCTKEE 236

  Fly   226 ---FFKQAQQVGLVTSDYRYIIGNLDWHTMDLEPYQHAGTNITGLRLVSPDSEQVQEVAKALYES 287
               .|:.|..|||....|.:|:.:|.....|..|.:..    |||..||.|.
  Rat   237 ATYIFEVANSVGLTGYGYTWIVPSLVAGDTDTVPSEFP----TGLISVSYDE------------- 284

  Fly   288 EEPFQNVSCPLTNSMALVYDGVQLL----AETYKHVNFRPVALSCNDDSAWDKGY---TLVNYMK 345
                .:...|     |.|.||:.::    ::.....:|.|...|...::...:.|   .|..|:.
  Rat   285 ----WDYGLP-----ARVRDGIAIITTAASDMLSEHSFIPEPKSSCYNTHEKRIYQSNMLNRYLI 340

  Fly   346 SLTLNGLTGPIRFDYEGLRTDFKLEVIEL-AVSGMQKIGQWSGEDGFQEN-----RPAP-AHSLE 403
            ::|..|..  :.|..:|.:...||.:|.| .....:::|:|. :...|..     |..| ....|
  Rat   341 NVTFEGRN--LSFSEDGYQMHPKLVIILLNKERKWERVGKWK-DKSLQMKYYVWPRMCPETEEQE 402

  Fly   404 PDMRSLV---NKSFVVITAI-------------------------SEPYGMLKETSEKLEGNDQF 440
            .|..|:|   ...||::.::                         .|| |.:|:..
  Rat   403 DDHLSIVTLEEAPFVIVESVDPLSGTCMRNTVPCQKRIISENKTDEEP-GYIKKCC--------- 457

  Fly   441 EGFGIELIDELSKKLGFSYTWRLQEDNKYGGIDPKTGEWNGMLREIIDSRADMGITDLTMTSERE 505
            :||.|:::.::||.:.|:|...|..:.|:|  ....|.||||:.|::..||.|.:..||:..||.
  Rat   458 KGFCIDILKKISKSVKFTYDLYLVTNGKHG--KKINGTWNGMIGEVVMKRAYMAVGSLTINEERS 520

  Fly   506 SGVDFTIPFMSLGIGILF-RKPMKEPPKLFSFMSPFSGEVWLWLGLAYMGVS-ISMFVLGRLSPA 568
            ..|||::||:..||.::. |......|.  :|:.|||.:||:.:.:..:.|| :::||....||.
  Rat   521 EVVDFSVPFIETGISVMVSRSNGTVSPS--AFLEPFSADVWVMMFVMLLIVSAVAVFVFEYFSPV 583

  Fly   569 EWDNPYPCIEEPTELEN-QFSFANCLWFSIGALLQQGSELA-PKAYSTRAVAASWWFFTLILVSS 631
            .::.   |:.:..|... .|:....:|...|.:......:. ||..:::.:.:.|.||.:|.::|
  Rat   584 GYNR---CLADGREPGGPSFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLAS 645

  Fly   632 YTANLAAFLTVESLVTPINDADDLSKNKGG-----VNYGAKIGGATFNFFKESNYPTYQRMYEFM 691
            ||||||||:..|..|..::...|....:..     ..:|....|:|....:.:    |..|:
  Rat   646 YTANLAAFMIQEEYVDQVSGLSDKKFQRPNDFSPPFRFGTVPNGSTERNIRNN----YAEMH--- 703

  Fly   692 RDNPQYMTNTNQEGVD---------RVENSNYAFLMESTTIEYITER--RCTLTQVGA--LLDEK 743
                .||...||.|||         :::    ||:.::..:.|:..|  .|.|..:|:  :....
  Rat   704 ----AYMGKFNQRGVDDALLSLKTGKLD----AFIYDAAVLNYMAGRDEGCKLVTIGSGKVFAST 760

  Fly   744 GYGIAMRKNWPYRDTLSQAVLEMQEQGLLTKMKTKWWQEKRGGGACSDADEDSGAVALEISNLGG 808
            |||||::|:..::..:..|:|::...|.:.:::..|..     |.|.:...:..:..|:|.|:.|
  Rat   761 GYGIAIQKDSGWKRQVDLAILQLFGDGEMEELEALWLT-----GICHNEKNEVMSSQLDIDNMAG 820

  Fly   809 VFLVMGV-------------------------------GSFFGIFVSLLEMVLGVKERSDENQVS 842
            ||.::|.                               |..|.|...:...:.||.....::.::
  Rat   821 VFYMLGAAMALSLITFICEHLFYWQFRHCFMGVCSGKPGMVFSISRGIYSCIHGVAIEERQSVMN 885

  Fly   843 FKTELLDE-----IRFILQCSGNTKAVKYPKNSSRSNASSKSKGSSMSVDSLPEDTSEADASGKH 902
            ..|..::.     :|.:       :..|...|.|..|.|.:|....:..:|...|.||...|..|
  Rat   886 SPTATMNNTHSNILRLL-------RTAKNMANLSGVNGSPQSALDFIRRESSVYDISEHRRSFTH 943

  Fly   903 NHGK 906
            :..|
  Rat   944 SDCK 947

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.