Protein Alignment Grik and Grin1

DIOPT Version :10

• Sequence 1: NP_001262788.1
• Gene: Grik / 42476
• FlyBaseID: FBgn0038840
• Length: 907
• Species: Drosophila melanogaster
• Sequence 2: NP_001257531.1
• Gene: Grin1 / 24408
• RGDID: 2736
• Length: 959
• Species: Rattus norvegicus
• Alignment Length: 1002
• Identity: 224/1002 - (22%)
• Similarity: 402/1002 - (40%)
• Gaps: 203/1002 - (20%)

  Fly    18 ILTSLLLAFPGCRGERTNVGLVYENTDPDLEKIFHLAISKANEENED--LQLHGVSVSIEPGNSF 80
            :|.|...|...|..:..|:|.|......  |::|..|:::||:.:..  :||:..||:.:| |:.
  Rat    11 LLFSCSFARAACDPKIVNIGAVLSTRKH--EQMFREAVNQANKRHGSWKIQLNATSVTHKP-NAI 72

  Fly    81 ETSKKLCK-MLRQNLVAVF---GPTSN-------------------LAARHAMSICDAKELPFLD 122
            :.:..:|: ::...:.|:.   .||.|                   |.....|||...|.:..
  Rat    73 QMALSVCEDLISSQVYAILVSHPPTPNDHFTPTPVSYTAGFYRIPVLGLTTRMSIYSDKSIHL-- 135

  Fly   123 TRWDFGAQLPTINLHPHPATLGVALRDMVVALGWESFTIIYESGEYLPTVRELLQMYGTAGPTVT 187
                  :.|.|:..:.|.:::..   :|:....|....::..........::.|:       |:.
  Rat   136 ------SFLRTVPPYSHQSSVWF---EMMRVYNWNHIILLVSDDHEGRAAQKRLE-------TLL 184

  Fly   188 VRRYELDLNGNYRN-----------------------------VLRRIRNADDFSFVVVGSMATL 223
            ..|.......||.|                             :|...|..:....::..|....
  Rat   185 EERESKSKKRNYENLDQLSYDNKRGPKAEKVLQFDPGTKNVTALLMEARELEARVIILSASEDDA 249

  Fly   224 PEFFKQAQQVGLVTSDYRYIIGNLDWHTMDLEPYQHAGTNITGLRLVSPDSEQ------VQEVAK 282
            ...::.|..:.:..|.|.:::|..:   :.....::|...|.||:|::..:|.      |..||:
  Rat   250 ATVYRAAAMLNMTGSGYVWLVGERE---ISGNALRYAPDGIIGLQLINGKNESAHISDAVGVVAQ 311

  Fly   283 ALYESEEPFQNVSCPLTNSMALVYDGVQLLAETYKHVNFRPVALSCNDDSAWDKGYTLVN-YMKS 346
            |::|..|. :|::.|....:                          .:.:.|..|..... .|.|
  Rat   312 AVHELLEK-ENITDPPRGCV--------------------------GNTNIWKTGPLFKRVLMSS 349

  Fly   347 LTLNGLTGPIRFDYEGLRTDFKLEVIELAVSGMQKIGQWSGEDGFQENRPA--PAHSLEPDMRSL 409
            ...:|:||.:.|:.:|.|......::.|....:.::|.::|......:|..  |....|......
  Rat   350 KYADGVTGRVEFNEDGDRKFANYSIMNLQNRKLVQVGIYNGTHVIPNDRKIIWPGGETEKPRGYQ 414

  Fly   410 VNKSFVVITAISEPYGMLKETSEKLEGNDQFE-------------------------------GF 443
            ::....::|...||:..:|.|.......::|.                               ||
  Rat   415 MSTRLKIVTIHQEPFVYVKPTMSDGTCKEEFTVNGDPVKKVICTGPNDTSPGSPRHTVPQCCYGF 479

  Fly   444 GIELIDELSKKLGFSYTWRLQEDNKYGGID----PKTGEWNGMLREIIDSRADMGITDLTMTSER 504
            .|:|:.:|::.:.|:|...|..|.|:|..:    ....|||||:.|::..:|||.:..||:.:||
  Rat   480 CIDLLIKLARTMNFTYEVHLVADGKFGTQERVNNSNKKEWNGMMGELLSGQADMIVAPLTINNER 544

  Fly   505 ESGVDFTIPFMSLGIGILFRKPMKEPPK--LFSFMSPFSGEVWLWLGLAYMGVSISMFVLGRLSP 567
            ...::|:.||...|:.||.:   ||.|:  |.|||.||...:||.:||:...|::.:::|.|.||
  Rat   545 AQYIEFSKPFKYQGLTILVK---KEIPRSTLDSFMQPFQSTLWLLVGLSVHVVAVMLYLLDRFSP 606

  Fly   568 AEWDNPYPCIEEPTELENQFSFANCLWFSIGALLQQG-SELAPKAYSTRAVAASWWFFTLILVSS 631
            .....    :....|.|:..:.::.:|||.|.||..| .|.||:::|.|.:...|..|.:|:|:|
  Rat   607 FGRFK----VNSEEEEEDALTLSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVWAGFAMIIVAS 667

  Fly   632 YTANLAAFLTV---ESLVTPINDADDLSKNKGGVNYGAKIGGATFNFF----KESNYPTYQR--- 686
            |||||||||.:   |..:|.|||              .::...:..|.    |:|:...|.|
  Rat   668 YTANLAAFLVLDRPEERITGIND--------------PRLRNPSDKFIYATVKQSSVDIYFRRQV 718

  Fly   687 ----MYEFMRDNPQYMTNTNQEGVDRV-ENSNYAFLMESTTIEYITERRCTLTQVGALLDEKGYG 746
                ||..|.   ::...:..|.:..| :|..:||:.:|..:|:...::|.|...|.|....|:|
  Rat   719 ELSTMYRHME---KHNYESAAEAIQAVRDNKLHAFIWDSAVLEFEASQKCDLVTTGELFFRSGFG 780

  Fly   747 IAMRKNWPYRDTLSQAVLEMQEQGLLTKMKTKW--WQEKRGGGACSDADEDSGAVA-LEISNLGG 808
            |.|||:.|::..:|.::|:..|.|.:..:...|  :||         .|..|.|.| |...|:.|
  Rat   781 IGMRKDSPWKQNVSLSILKSHENGFMEDLDKTWVRYQE---------CDSRSNAPATLTFENMAG 836

  Fly   809 VFLVMGVGSFFGIFVSLLEMVLGVKERSDENQVSFKTELLDEIRFILQCSGNTKAVKYPKNSSRS 873
            ||:::..|...|||:..:|:.....:.:...|:......::..|..||...:.:|...||..:..
  Rat   837 VFMLVAGGIVAGIFLIFIEIAYKRHKDARRKQMQLAFAAVNVWRKNLQDRKSGRAEPDPKKKATF 901

  Fly   874 NASSKSKGSSMSVDSLPEDTSEADASG 900
            .|.:.:..||.......:|||.....|
  Rat   902 RAITSTLASSFKRRRSSKDTSTGGGRG 928

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Grik	NP_001262788.1	PBP1_iGluR_Kainate	35..395	CDD:380605	69/420 (16%)
		Periplasmic_Binding_Protein_Type_2	411..781	CDD:473866	118/424 (28%)
Grin1	NP_001257531.1	PBP1_iGluR_NMDA_NR1	25..404	CDD:380602	70/429 (16%)
		PBP2_iGluR_NMDA_Nr1	416..820	CDD:270437	120/436 (28%)
		CaM_bdg_C0	856..884	CDD:402271	2/27 (7%)