DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Grik and Grik5

DIOPT Version :9

Sequence 1:	NP_001262788.1	Gene:	Grik / 42476	FlyBaseID:	FBgn0038840	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	XP_006228444.1	Gene:	Grik5 / 24407	RGDID:	2735	Length:	980	Species:	Rattus norvegicus

Alignment Length:	923	Identity:	310/923 - (33%)
Similarity:	508/923 - (55%)	Gaps:	100/923 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 ILTSLLLAF--PGC-------------------RGERTNVGLVYENTDPDLEKIFHLAISKANEE 61
            :|..|::||  |.|                   ||||..:.|..|..:..:|     ..:||..|
  Rat     5 LLLLLIVAFANPSCQVLSSLRMAAILDDQTVCGRGERLALALAREQINGIIE-----VPAKARVE 64

  Fly    62 NEDLQLHGVSVSIEPGNSFETSKKLCKMLRQNLVAVFGPTSNLAARHAMS-ICDAKELPFLDT-- 123
            .:..:|       :..:.:||:..:|::|.:.:|:|.||:|:.|:...:| ||..||:|.:..
  Rat    65 VDIFEL-------QRDSQYETTDTMCQILPKGVVSVLGPSSSPASASTVSHICGEKEIPHIKVGP 122

  Fly   124 ----RWDFGAQLPTINLHPHPATLGVALRDMVVALGWESFTIIYESGEYLPTVRELLQMYGTAGP 184
                |..: .:..:::|:|....:.:|:..::.:..:.|.::|....|.|..:.||::.:..:..
  Rat   123 EETPRLQY-LRFASVSLYPSNEDVSLAVSRILKSFNYPSASLICAKAECLLRLEELVRGFLISKE 186

  Fly   185 TVTVRRYELDLNGNYRNVLRRIRNADDFSFVVVGSMATLPEF-FKQAQQVGLVTSDYRYIIGNLD 248
            |::||.  ||.:.:...:|:.||: |..|.:::.:.|::... .::|.::|:.::.|:||:..:|
  Rat   187 TLSVRM--LDDSRDPTPLLKEIRD-DKVSTIIIDANASISHLVLRKASELGMTSAFYKYILTTMD 248

  Fly   249 WHTMDLEPYQHAGTNITGLRLVSPDSEQVQEVAKALYESEEPFQNVS----CPLTN------SMA 303
            :..:.|:......:||.|..:.:.......|..::|        |:|    |..:.      |.|
  Rat   249 FPILHLDGIVEDSSNILGFSMFNTSHPFYPEFVRSL--------NMSWRENCEASTYPGPALSAA 305

  Fly   304 LVYDGVQLLAETYKHVN------FRPVALSCNDDSAWDKGYTLVNYMKSLTLNGLTGPIRFDYEG 362
            |::|.|.::....:.:|      .:|  |:|...:.|..|.:|:||::.:..:||||.:.|:.:|
  Rat   306 LMFDAVHVVVSAVRELNRSQEIGVKP--LACTSANIWPHGTSLMNYLRMVEYDGLTGRVEFNSKG 368

  Fly   363 LRTDFKLEVIELAVSGMQKIGQWSGEDGFQENRPAPAHSLEPDM---RSLVNKSFVVITAISEPY 424
            .||::.|.::|.:..|.::||.|      ..||....::...|:   ::|.||:.||.|.:..||
  Rat   369 QRTNYTLRILEKSRQGHREIGVW------YSNRTLAMNATTLDINLSQTLANKTLVVTTILENPY 427

  Fly   425 GMLKETSEKLEGNDQFEGFGIELIDELSKKLGFSYTWRLQEDNKYGGIDPKTGEWNGMLREIID- 488
            .|.:...:.|.||::||||.::::.||::.|.|.|..||.||..||..:| .|.|.||:.|:|:
  Rat   428 VMRRPNFQALSGNERFEGFCVDMLRELAELLRFRYRLRLVEDGLYGAPEP-NGSWTGMVGELINR 491

  Fly   489 SRADMGITDLTMTSERESGVDFTIPFMSLGIGILFRKPMKEPPKLFSFMSPFSGEVWLWLGLAYM 553
            .:||:.:...|:|:|||..:||:.|||:|||.||:|..|...|..|||:.|||..|||::.|||:
  Rat   492 QKADLAVAAFTITAEREKVIDFSKPFMTLGISILYRVHMGRKPGYFSFLDPFSPAVWLFMLLAYL 556

  Fly   554 GVSISMFVLGRLSPAEWDNPYPCIE-EPTELENQFSFANCLWFSIGALLQQGSELAPKAYSTRAV 617
            .||..:|:..||||.||.||:||:. .|..||||::..|.|||.:|..:|||||:.|:|.|||.|
  Rat   557 AVSCVLFLAARLSPYEWYNPHPCLRARPHILENQYTLGNSLWFPVGGFMQQGSEIMPRALSTRCV 621

  Fly   618 AASWWFFTLILVSSYTANLAAFLTVESLVTPINDADDLSKNKGGVNYGAKIGGATFNFFKESNYP 682
            :..||.||||::|||||||||||||:.:..|:..||||: ::..:.||....|:|..||:.|.|.
  Rat   622 SGVWWAFTLIIISSYTANLAAFLTVQRMEVPVESADDLA-DQTNIEYGTIHAGSTMTFFQNSRYQ 685

  Fly   683 TYQRMYEFMRD-NPQYMTNTNQEGVDRVENSNYAFLMESTTIEYITERRCTLTQVGALLDEKGYG 746
            |||||:.:|:. .|.....:.:||:.||.||.||||:|||..||.....|.|||:|.|||.||||
  Rat   686 TYQRMWNYMQSKQPSVFVKSTEEGIARVLNSRYAFLLESTMNEYHRRLNCNLTQIGGLLDTKGYG 750

  Fly   747 IAMRKNWPYRDTLSQAVLEMQEQGLLTKMKTKWWQEKRGGGACSDADEDSGAVALEISNLGGVFL 811
            |.|....|:||.::.|:|::||...|..:|.|||:    ||.| ..:||..|..|.:.|:||:|:
  Rat   751 IGMPLGSPFRDEITLAILQLQENNRLEILKRKWWE----GGRC-PKEEDHRAKGLGMENIGGIFV 810

  Fly   812 VMGVGSFFGIFVSLLEMVLGVKERSDENQVSFKTELLDEIRFILQCSGNTKAVKYPKNSSRSNAS 876
            |:..|....:||:::|.:...:..::..:||...|:|.|:|..:.|          :.:|||...
  Rat   811 VLICGLIIAVFVAVMEFIWSTRRSAESEEVSVCQEMLQELRHAVSC----------RKTSRSRRR 865

  Fly   877 SKSKGSSMSVDSL 889
            .:..|.|.::.||
  Rat   866 RRPGGPSRALLSL 878

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Grik	NP_001262788.1	PBP1_iGluR_Kainate	37..391	CDD:107377	87/377 (23%)
		ANF_receptor	53..374	CDD:279440	79/344 (23%)
		Periplasmic_Binding_Protein_Type_2	411..781	CDD:304360	178/372 (48%)
		Lig_chan	543..816	CDD:278489	132/274 (48%)
Grik5	XP_006228444.1	PBP1_iGluR_Kainate_KA1_2	23..401	CDD:380616	93/409 (23%)
Grik5	XP_006228444.1	Periplasmic_Binding_Protein_Type_2	414..785	CDD:389745	178/372 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349894
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	1	1.010	-	-		D60688at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.760