DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Grik and Grin3a

DIOPT Version :9

Sequence 1:	NP_001262788.1	Gene:	Grik / 42476	FlyBaseID:	FBgn0038840	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	NP_001263284.1	Gene:	Grin3a / 242443	MGIID:	1933206	Length:	1135	Species:	Mus musculus

Alignment Length:	1002	Identity:	205/1002 - (20%)
Similarity:	376/1002 - (37%)	Gaps:	272/1002 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MWFVKMISTEASFPLGFILT----------SLLLAFPGCRGERTNVGLV---------------- 39
            |.|....|..:|.|..|:.:          |.|||||..:||...:.||
Mouse   164 MPFSSPSSPWSSDPFSFLQSVCHTVVVQGVSALLAFPQSQGEMMELDLVSSVLHIPVLSIVRHEF 228

  Fly    40 -YENTDPDLEKIFHLAISKANEENEDLQLHGVSVSI-EPGNSFETSKKLCKMLRQNLVAVFGPTS 102
             .|:.:|     .||.:|..|..:.|..   |:||| ...|.:..|..||:. ..|:......|.
Mouse   229 PRESQNP-----LHLQLSLENSLSSDAD---VTVSILTMNNWYNFSLLLCQE-DWNITDFLLLTE 284

  Fly   103 NLAARHAMSICDAKELPFLDTRWDFGAQLPTINLHPHPATLGVALRDMVVALGWESFTIIYESGE 167
            |.:..|..||.:.                 |.||.        :.:|::      ||
Mouse   285 NNSKFHLESIINI-----------------TANLS--------STKDLL------SF-------- 310

  Fly   168 YLPTVRELLQMYGTAGPTVTVRRYELDLNGNYRNVLRRIRNADDFSFVVVG-SMATLPEFFKQAQ 231
                    ||:.                       |..|||:.. :.|:.| .|.::.:.|:.:.
Mouse   311 --------LQVQ-----------------------LENIRNSTP-TMVMFGCDMGSIRQIFEMST 343

  Fly   232 QVGLVTSDYRYIIGNLDWHTMDLEPYQHAGTNITGLRLVSPDSEQVQEVAK-----ALYESEEPF 291
            |.||...|..:::|                           ||:.|:|:..     .|....:..
Mouse   344 QFGLSPPDLHWVLG---------------------------DSQNVEELRTEGLPLGLIAHGKTT 381

  Fly   292 QNV-SCPLTNSMALVYDGVQLLAETYKHVNFRPVALSCNDDSAWD--KGYTLVNYMKSLTLNGLT 353
            |:| ...:.::|.||...|.........:...|..::|.|....:  .|..|..::.:.|..||:
Mouse   382 QSVFEYYVQDAMELVARAVATATMIQPELALLPSTMNCMDVKTTNLTSGQYLSRFLANTTFRGLS 446

  Fly   354 GPIRFDYEGLRTD------FKLEVIELAVSGMQKIGQWSG-----EDGF--QENRPAPAHSLEPD 405
            |.|:.....:.:.      :.|:...:......::|.|.|     :.|.  ::.:....|...|
Mouse   447 GSIKVKGSTIVSSENNFFIWNLQYDPMGKPMWTRLGSWQGGRIVMDSGIWPEQAQRHKTHFHHP- 510

  Fly   406 MRSLVNKSFV-VITAISEPYGMLKETSEKLEG-----------------------------ND-- 438
                 ||..: |:|.|..|:...:|..:  ||                             ||
Mouse   511 -----NKLHLRVVTLIEHPFVFTREVDD--EGLCPAGQLCLDPMTNDSSILDSLFSSLHSSNDTV 568

  Fly   439 --QFE----GFGIELIDELSKKLGFSYTWRLQEDNKYGGIDPKTGEWNGMLREIIDSRADMGITD 497
              :|:    |:.|:|:::|::.:.|.:...:..|.|||..  |.|.|.|::.:::...|:|.:|.
Mouse   569 PIKFKKCCYGYCIDLLEQLAEDMNFDFDLYIVGDGKYGAW--KNGHWTGLVGDLLSGTANMAVTS 631

  Fly   498 LTMTSERESGVDFTIPFMSLGIGILFRKPMKEPPKLFSFMSPFSGEVWLWLGLAYMGVSISMFVL 562
            .::.:.|...:|||.||.|..:|||.|......| :.:||.|....:||       |:.:::.:.
Mouse   632 FSINTARSQVIDFTSPFFSTSLGILVRTRDTAAP-IGAFMWPLHWTMWL-------GIFVALHIT 688

  Fly   563 G-RLSPAEWDNPYPCIEEPTELENQFSFANCLWFSIGALLQQGSEL-APKAYSTRAVAASWWFFT 625
            . .|:..||.:|:....:.......|||::.|......|..:.:.: .||.::.|.:...|..|.
Mouse   689 AIFLTLYEWKSPFGMTPKGRNRNKVFSFSSALNVCYALLFGRTAAIKPPKCWTGRFLMNLWAIFC 753

  Fly   626 LILVSSYTANLAAFLTVESLVTPINDADD--LSKNKGGVNYGAKIGGATFNFFKESNYPTYQRMY 688
            :..:|:|||||||.:..|.:...::...|  |.....|..:|.....:..::.::|    :..|:
Mouse   754 MFCLSTYTANLAAVMVGEKIYEELSGIHDPKLHHPSQGFRFGTVRESSAEDYVRQS----FPEMH 814

  Fly   689 EFMR--------DNPQYMTNTNQEGVDRVENSNYAFLMESTTIEY--ITERRCTLTQVGALLDEK 743
            |:||        |..||:.| :.|.:|       ||:|:...::|  ..:..|.|..||.....:
Mouse   815 EYMRRYNVPATPDGVQYLKN-DPEKLD-------AFIMDKALLDYEVSIDADCKLLTVGKPFAIE 871

  Fly   744 GYGIAMRKNWPYRDTLSQAVLEMQEQGLLTKMKTKWWQEKRGGGACSDADEDSGAVALEISNLGG 808
            ||||.:..|.|....:|:.:.:.:..|.:..:..||::....|.......|   .:.:.|.:..|
Mouse   872 GYGIGLPPNSPLTSNISELISQYKSHGFMDVLHDKWYKVVPCGKRSFAVTE---TLQMGIKHFSG 933

  Fly   809 VFLVMGVGSFFGIFVSLLEMVL------GVKERS---------------------DENQVSFKTE 846
            :|:::.:|....|..::.|.::      .:|.:|                     :|.|...||:
Mouse   934 LFVLLCIGFGLSILTTIGEHIVYRLLLPRIKNKSKLQYWLHTSQRFHRALNTSFVEEKQPCSKTK 998

  Fly   847 LLDEI---RFILQCSGNTKAVKYPKNS 870
            .:::.   |:..:..|:::...:|:::
Mouse   999 RVEKSRWRRWTCKTEGDSELSLFPRSN 1025

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Grik	NP_001262788.1	PBP1_iGluR_Kainate	37..391	CDD:107377	69/391 (18%)
		ANF_receptor	53..374	CDD:279440	61/336 (18%)
		Periplasmic_Binding_Protein_Type_2	411..781	CDD:304360	102/421 (24%)
		Lig_chan	543..816	CDD:278489	64/286 (22%)
Grin3a	NP_001263284.1	PBP1_iGluR_NMDA_NR3	30..497	CDD:107372	84/439 (19%)
		PBP2_iGluR_NMDA_Nr3	512..908	CDD:270438	100/419 (24%)
		Lig_chan	676..942	CDD:278489	64/287 (22%)
		PPP2CB binding site. /evidence=ECO:0000250\|UniProtKB:Q9R1M7	951..987		3/35 (9%)
		GIT1-binding. /evidence=ECO:0000250\|UniProtKB:Q9R1M7	1082..1115
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846383
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840