DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Grik and Grin3a

DIOPT Version :9

Sequence 1:	NP_001262788.1	Gene:	Grik / 42476	FlyBaseID:	FBgn0038840	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	NP_612555.1	Gene:	Grin3a / 191573	RGDID:	621704	Length:	1135	Species:	Rattus norvegicus

Alignment Length:	1069	Identity:	210/1069 - (19%)
Similarity:	387/1069 - (36%)	Gaps:	324/1069 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MWFVKMISTEASFPLGFILT----------SLLLAFPGCRGERTNVGLV---------------- 39
            |.|....|..:|.|..|:.:          |.|||||..:||...:.||
  Rat   164 MPFSSPSSPWSSDPFSFLQSVCHTVVVQGVSALLAFPQSQGEMMELDLVSSVLHIPVLSIVRHEF 228

  Fly    40 -YENTDPDLEKIFHLAISKANEENEDLQLHGVSVSI-EPGNSFETSKKLCK---------MLRQN 93
             .|:.:|     .||.:|..|..:.|..   |:||| ...|.:..|..||:         :|.:|
  Rat   229 PRESQNP-----LHLQLSLENSLSSDAD---VTVSILTMNNWYNFSLLLCQEDWNITDFLLLTEN 285

  Fly    94 -----LVAVFGPTSNLAARHAMSICDAKELPFLDTRWDFGAQLPTINLHPHPATLGVALRDMVVA 153
                 |.:|...|:||::...:       |.||..:.|
  Rat   286 NSKFHLESVINITANLSSTKDL-------LSFLQVQMD--------------------------- 316

  Fly   154 LGWESFTIIYESGEYLPTVRELLQMYGTAGPTVTVRRYELDLNGNYRNVLRRIRNADDFSFVVVG 218
                                                               .|||:.. :.|:.|
  Rat   317 ---------------------------------------------------NIRNSTP-TMVMFG 329

  Fly   219 -SMATLPEFFKQAQQVGLVTSDYRYIIGNLDWHTMDLEPYQHAGTNITGLRLVSPDSEQVQEVAK 282
             .|.::.:.|:.:.|.||...:..:::|                           ||:.|:|:..
  Rat   330 CDMDSIRQIFEMSTQFGLSPPELHWVLG---------------------------DSQNVEELRT 367

  Fly   283 -----ALYESEEPFQNV-SCPLTNSMALVYDGVQLLAETYKHVNFRPVALSCNDDSAWD--KGYT 339
                 .|....:..|:| ...:.::|.||...|.........:...|..::|.|....:  .|..
  Rat   368 EGLPLGLIAHGKTTQSVFEYYVQDAMELVARAVATATMIQPELALLPSTMNCMDVKTTNLTSGQY 432

  Fly   340 LVNYMKSLTLNGLTGPIRFDYEGLRTD------FKLEVIELAVSGMQKIGQWSG-----EDGF-- 391
            |..::.:.|..||:|.|:.....:.:.      :.|:...:......::|.|.|     :.|.
  Rat   433 LSRFLANTTFRGLSGSIKVKGSTIISSENNFFIWNLQHDPMGKPMWTRLGSWQGGRIVMDSGIWP 497

  Fly   392 QENRPAPAHSLEPDMRSLVNKSFV-VITAISEPYGMLKETSEKLEG------------------- 436
            ::.:....|...|      ||..: |:|.|..|:...:|..:  ||
  Rat   498 EQAQRHKTHFQHP------NKLHLRVVTLIEHPFVFTREVDD--EGLCPAGQLCLDPMTNDSSML 554

  Fly   437 ----------ND----QFE----GFGIELIDELSKKLGFSYTWRLQEDNKYGGIDPKTGEWNGML 483
                      ||    :|:    |:.|:|:::|::.:.|.:...:..|.|||..  |.|.|.|::
  Rat   555 DRLFSSLHSSNDTVPIKFKKCCYGYCIDLLEQLAEDMNFDFDLYIVGDGKYGAW--KNGHWTGLV 617

  Fly   484 REIIDSRADMGITDLTMTSERESGVDFTIPFMSLGIGILFRKPMKEPPKLFSFMSPFSGEVWLWL 548
            .:::...|:|.:|..::.:.|...:|||.||.|..:|||.|......| :.:||.|....:||
  Rat   618 GDLLSGTANMAVTSFSINTARSQVIDFTSPFFSTSLGILVRTRDTAAP-IGAFMWPLHWTMWL-- 679

  Fly   549 GLAYMGVSISMFVLG-RLSPAEWDNPYPCIEEPTELENQFSFANCLWFSIGALLQQGSEL-APKA 611
                 |:.:::.:.. .|:..||.:|:....:.......|||::.|......|..:.:.: .||.
  Rat   680 -----GIFVALHITAIFLTLYEWKSPFGMTPKGRNRNKVFSFSSALNVCYALLFGRTAAIKPPKC 739

  Fly   612 YSTRAVAASWWFFTLILVSSYTANLAAFLTVESLVTPINDADD--LSKNKGGVNYGAKIGGATFN 674
            ::.|.:...|..|.:..:|:|||||||.:..|.:...::...|  |.....|..:|.....:..:
  Rat   740 WTGRFLMNLWAIFCMFCLSTYTANLAAVMVGEKIYEELSGIHDPKLHHPSQGFRFGTVRESSAED 804

  Fly   675 FFKESNYPTYQRMYEFMR--------DNPQYMTNTNQEGVDRVENSNYAFLMESTTIEY--ITER 729
            :.::|    :..|:|:||        |..||:.| :.|.:|       ||:|:...::|  ..:.
  Rat   805 YVRQS----FPEMHEYMRRYNVPATPDGVQYLKN-DPEKLD-------AFIMDKALLDYEVSIDA 857

  Fly   730 RCTLTQVGALLDEKGYGIAMRKNWPYRDTLSQAVLEMQEQGLLTKMKTKWWQEKRGGGACSDADE 794
            .|.|..||.....:||||.:..|.|....:|:.:.:.:..|.:..:..||::....|.......|
  Rat   858 DCKLLTVGKPFAIEGYGIGLPPNSPLTSNISELISQYKSHGFMDVLHDKWYKVVPCGKRSFAVTE 922

  Fly   795 DSGAVALEISNLGGVFLVMGVGSFFGIFVSLLEMVL------GVKERS----------------- 836
               .:.:.|.:..|:|:::.:|....|..::.|.::      .:|.:|
  Rat   923 ---TLQMGIKHFSGLFVLLCIGFGLSILTTIGEHIVHRLLLPRIKNKSKLQYWLHTSQRFHRALN 984

  Fly   837 ----DENQVSFKTELLDEI---RFILQCSGNTKAVKYPKNS---------SRSNASSKSK----- 880
                :|.|...||:.:::.   |:..:..|:::...:|:::         :.||.|..::
  Rat   985 TSFVEEKQPRSKTKRVEKSRWRRWTCKTEGDSELSLFPRSNLGPQQLMVWNTSNLSHDNQRKYIF 1049

  Fly   881 ---------GSSMSVD-SLPEDTSEADAS 899
                     |:....| .||:...|..||
  Rat  1050 NDEEGQNQLGTQAHQDIPLPQRRRELPAS 1078

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Grik	NP_001262788.1	PBP1_iGluR_Kainate	37..391	CDD:107377	64/405 (16%)
		ANF_receptor	53..374	CDD:279440	56/350 (16%)
		Periplasmic_Binding_Protein_Type_2	411..781	CDD:304360	102/421 (24%)
		Lig_chan	543..816	CDD:278489	64/286 (22%)
Grin3a	NP_612555.1	PBP1_iGluR_NMDA_NR3	30..497	CDD:107372	79/453 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	60..117
		ANF_receptor	127..469	CDD:279440	74/425 (17%)
		PBP2_iGluR_NMDA_Nr3	512..908	CDD:270438	100/419 (24%)
		Lig_chan	676..942	CDD:278489	64/287 (22%)
		PPP2CB binding site	951..987		3/35 (9%)
		GIT1-binding. /evidence=ECO:0000269\|PubMed:24297929	1082..1115
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349864
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840