Protein Alignment Grik and glr-8

DIOPT Version :10

• Sequence 1: NP_001262788.1
• Gene: Grik / 42476
• FlyBaseID: FBgn0038840
• Length: 907
• Species: Drosophila melanogaster
• Sequence 2: NP_001368711.1
• Gene: glr-8 / 180924
• WormBaseID: WBGene00001619
• Length: 547
• Species: Caenorhabditis elegans
• Alignment Length: 636
• Identity: 131/636 - (20%)
• Similarity: 219/636 - (34%)
• Gaps: 160/636 - (25%)

  Fly   291 FQNVSCPLTNSMALVYDGVQLLAETYKHVNFRPVALSCNDDSAWDKGYTLVNYMKSLTLNGLTGP 355
            |:|.:.. .||:..:.:.::.:.|...|    |...|...|  :...|||.| .|..:|:.:.|
 Worm     6 FENTTAD-PNSIRTLNNILESINEKVAH----PPQTSLTSD--YGDAYTLSN-EKHFSLSEMKG- 61

  Fly   356 IRFDYEGLRTDFKLEVIELAVSGMQKIGQWSGEDGFQENRPAPAHSLEPDMRSLVNKSFVVITAI 420
                    ||   |:::                        .||  :||...:.||.|...:|
 Worm    62 --------RT---LKMV------------------------VPA--IEPPYVNYVNFSDAAVT-- 87

  Fly   421 SEPYGMLKETSEKLEGNDQFEGFGIELIDELSKKLGFSY--------TWRLQEDNKYGGIDPKTG 477
            .:.||               .|..:|::.|:.|:|..:|        ||     .:|     ..|
 Worm    88 DKGYG---------------PGVVMEILKEIGKRLNLTYEILPALGSTW-----GEY-----LNG 127

  Fly   478 EWNGMLREIIDSRADMGITDLTMTSERESGVDFTIPFMSLGIGILFRKPMK-EPPKLFSFMSPFS 541
            .|.|...:::....|:......|..:|....|.|.||.....||:.|.|.| |...|.....|||
 Worm   128 SWTGAFGQLVRGEVDLLAGGAIMEYDRSVIADLTYPFQFEPTGIMIRSPEKYEDDTLLIVTEPFS 192

  Fly   542 GEVWLWLGLAYMGVSISMFVLGRLSPAEWD----NPYPCIEEPTELENQFSFANCLWFSIGALLQ 602
            .|||:......:...:...|:..:....::    .|:..|                |......:|
 Worm   193 WEVWVITAAVILISGVIFLVMTNIIRKVYEEMTVTPFESI----------------WVFFSIFVQ 241

  Fly   603 QGSELAPKAYSTRAVAASWWFFTLILVSSYTANLAAFLTVESLVTPINDADDLSKNKGGVNYGAK 667
            ||....|:::|.|.:.|.||..::.|.:::|.:|.|...|:....|..:.|.|.:......:...
 Worm   242 QGLPEQPRSWSCRVLVALWWLASITLSATFTGSLVALFAVDKTNVPFQNIDQLVRLVKQGKFEIV 306

  Fly   668 IGGATF---NFFKESNYPTYQRM-YEFMRDNPQYMTNTNQEGVDRVE-NSNYAFLMESTTIEYIT 727
            :...:|   .....|..|.|:.: :|.:.::.....|....||..|. |..||.|....|:.:..
 Worm   307 MDENSFTRTEMIARSKLPVYRDLWHEMIVNHKVKYVNGIARGVAFVRANPGYALLGPMATLNFYA 371

  Fly   728 ERRCTLTQVGALLDEKG-----YGIAMRKNWPYRDTLSQAVLEMQEQGLLTKMKTKWWQEKRGGG 787
            ...|.:     :|...|     ..|.:.||..|....|..:.||.|:|    ...||..:.|...
 Worm   372 YSDCKV-----ILFNDGILPVYLSIPLVKNSIYSPYFSTKIREMVERG----FTQKWIADYRSYV 427

  Fly   788 ACSDADEDSGAVA-----LEISNLGGVFLV------MGVGSFFGIFVSLLEMVLGVKERSDENQV 841
            |....:|.:....     |::....|.|.|      :|:..|.|.|:
 Worm   428 AMQKINECNSTTIGPKSYLDLKRAQGAFWVFLGGAGLGLALFVGEFI------------------ 474

  Fly   842 SFKTELLDEIRFILQCSGNTKAVKYPKNSSRSNASSKSKGSSMSV--DSLP 890
             ||.       |..:.:.:||....|...:..:|:.....:|:.:  :.||
 Worm   475 -FKF-------FREKMTKHTKTTTVPPEVATVSANVAENSTSLDIPDEVLP 517

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Grik	NP_001262788.1	PBP1_iGluR_Kainate	35..395	CDD:380605	19/103 (18%)
		Periplasmic_Binding_Protein_Type_2	411..781	CDD:473866	86/392 (22%)
glr-8	NP_001368711.1	PBP2_iGluR_ligand_binding	62..424	CDD:270219	94/442 (21%)