DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Grik and glr-5

DIOPT Version :9

Sequence 1:	NP_001262788.1	Gene:	Grik / 42476	FlyBaseID:	FBgn0038840	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	NP_505244.1	Gene:	glr-5 / 179251	WormBaseID:	WBGene00001616	Length:	932	Species:	Caenorhabditis elegans

Alignment Length:	950	Identity:	288/950 - (30%)
Similarity:	470/950 - (49%)	Gaps:	137/950 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 VGLVY-ENTDPDLEKIFHLAISKANEEN--EDLQLHGVSVSIEPGNSFETSKKLCKML-RQNLVA 96
            :|.:: |..|..:|.....::...::..  .|:.|  |...|:..:.::..||.|||| :.::||
Worm    27 IGAIFREREDAHIEAAVRYSVEWLSQRGIYGDIDL--VIEYIDVLDHYDAIKKACKMLEKDHIVA 89

  Fly    97 VFGPTSNLAARHAMSICDAKELPFL----DTRWDFGAQLPTINLHPHPATLGVALRDMVVALGWE 157
            :.|.:..........|.|..::|||    |.|.|.|..  .|:..|.| .|..|:.||.....|.
Worm    90 LLGGSHAALNAQLERITDDLDIPFLTAIDDLRTDMGKS--KIDFWPRP-QLFEAVVDMFTHWRWN 151

  Fly   158 SFTIIYESGEYLPTVRELLQMYGTAGPTVTVRRYELDL-NGNYRNVLRRI-----------RNAD 210
            ...::||..|.:..:.:||:....|    ::|.|.:.: :|:|....|::           ::..
Worm   152 RIVLVYEGDERIRRLEQLLESEEYA----SIRFYLIKVHDGDYMKAARQVKELEECRLLHKKDCS 212

  Fly   211 DFSFVVVGSMATLPE----FFKQAQQVGLVTSDYRYIIGNLDWHTMDLE--PYQHAGTNITGLRL 269
            :||.::|...   ||    |...:.|:||:...:.:::.|::..|||:|  .|.||       |.
Worm   213 EFSRLLVDMN---PEHTYTFLLASLQMGLIELKHWFLLTNMELSTMDMELFRYNHA-------RF 267

  Fly   270 VSP---DSEQVQEVAKAL---YESEEPFQNVSCPLTNSMAL-------VYDGVQLLAETYK---- 317
            :||   ||..:.|...|.   :..|...:..:....||..|       .:|.|...|..:.
Worm   268 ISPYPVDSTFLTENRDAFNFSHFKEHITEKWAMKTDNSRNLKMMEAVFTFDAVYAFANVFNELSS 332

  Fly   318 --HVNFRPVAL---SCNDDSAWDKGYTLVNYMKSLTLNGLTGPI-RFDYEGLRTDFKLEVIELAV 376
              .:|..|..|   |..:...:..|.:|::.:....|:||:|.: |.:...|:::|.:.:..|..
Worm   333 HMQMNDVPQTLCRKSSRNSRKYQHGRSLIDNIVHNDLHGLSGDLRRLNGHPLKSNFSMRIQLLGY 397

  Fly   377 SG-MQKIGQW----------SGEDGFQENRPAP-AHSLEPDMRSLVNKSFVVITAISEPYGMLKE 429
            || :..||.|          ||:...|..|... :..|:|..|        |.|.:..||.|||:
Worm   398 SGRLDDIGFWEPATNVHVNMSGDSKAQLQRNVQVSDELKPHFR--------VTTIMERPYVMLKK 454

  Fly   430 TSEKLEGNDQFEGFGIELIDELSKKLGFSYTWRLQEDNKYGGIDPKTGEWNGMLREIIDSRADMG 494
            ...:|:.|.:||||.|:|:.||||.|||:||....:|.|||......|.|:||:.||:...|:|.
Worm   455 NHYELDANSKFEGFCIDLLAELSKDLGFTYTIHAVKDGKYGNDKYGNGSWDGMMGEILRGEAEMA 519

  Fly   495 ITDLTMTSERESGVDFTIPFMSLGIGILFRKPMKEPPKLFSFMSPFSGEVWLWLGLAYMGVSISM 559
            :..||:...|...||||.||:||||.||::.|..:.|.||||::|.|.::|..:..:.:.|::.|
Worm   520 VAPLTVNYRRSEAVDFTKPFLSLGISILYKVPDDQQPDLFSFLNPLSWQIWTAIATSIITVTLGM 584

  Fly   560 FVLGRLSPAEWD---------NPYPCI------EEPTELENQFSFANCLWFSIGALLQQGSELAP 609
            :.:..::|.||:         .|:|..      |.|..:.|.:||.|.:|:.:..:|:.|.:..|
Worm   585 YFVANVTPYEWNLNFSCCTAHEPHPAAAFATNQEAPIVMSNNYSFWNTVWYVLSTMLKGGCDFGP 649

  Fly   610 KAYSTRAVAASWWFFTLILVSSYTANLAAFLTVESLVTPINDADDLSKNKGGVNYGAKIGGATFN 674
            :|.|||.:..:||.|.|:::|:|||||||.|||.....||.:.|||: |:..::||...||:|..
Worm   650 RAVSTRLLGGTWWVFYLVIISAYTANLAAVLTVSRPYIPIKNLDDLA-NQTTISYGTIRGGSTMQ 713

  Fly   675 FFKESNYPTYQRMYEFMRDNPQYMTNTNQEGVDRVENSNYAFLMESTTIEYITERRCTLTQVGAL 739
            ||:||....:.:|:::|:|...::| :|.:||:|..:.|||:|||||::||.|::.|.|||:|.:
Worm   714 FFQESRIAAHVKMWQYMKDKDVFVT-SNGKGVERALSMNYAYLMESTSLEYETQQNCNLTQIGGV 777

  Fly   740 LDEKGYGIAMRKNWPYRDTLSQAVLEMQEQGLLTKMKTKWWQEKRGGGACSDADEDSGAV----- 799
            |..||||||:.|...:.|.:|:.:|...::|::...|||||:.|  |.||:..   :.||
Worm   778 LGSKGYGIALAKKSEWTDRISRQILLYAKRGIIEMKKTKWWRSK--GAACAST---ASAVKHDRF 837

  Fly   800 ALEISNLGGVFLVMGVGSFFGIFVSLLEMVLGVKERSDENQVSFKTELLDEIRFILQCSGNTKAV 864
            ||.:.|:.|:|:.:|||......|.:.|::......:.:....|..|||.|:||.|..
Worm   838 ALSMYNVAGLFITLGVGIVLAAIVVIFELIHRCHHIAKKEGKPFLEELLYELRFALNM------- 895

  Fly   865 KYPKNSSRSNASSKSKGSSMSVDSLPEDTSEADASGKHNH 904
                 :|.|:..|:.|.|          |..::.:||.||
Worm   896 -----NSLSDHRSRQKMS----------TCNSNGNGKPNH 920

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Grik	NP_001262788.1	PBP1_iGluR_Kainate	37..391	CDD:107377	97/413 (23%)
		ANF_receptor	53..374	CDD:279440	85/368 (23%)
		Periplasmic_Binding_Protein_Type_2	411..781	CDD:304360	151/384 (39%)
		Lig_chan	543..816	CDD:278489	105/292 (36%)
glr-5	NP_505244.1	PBP1_iGluR_delta_like	26..418	CDD:107376	95/409 (23%)
		ANF_receptor	38..377	CDD:279440	83/357 (23%)
		PBP2_iGluR_Kainate	438..819	CDD:270432	152/390 (39%)
		Lig_chan	568..855	CDD:278489	106/293 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	102	1.000	Domainoid score	I4290
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	495	1.000	Inparanoid score	I765
Isobase	1	0.950	-	0	Normalized mean entropy	S3952
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D60688at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		otm14234
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.920