Protein Alignment Grik and glr-1

DIOPT Version :10

• Sequence 1: NP_001262788.1
• Gene: Grik / 42476
• FlyBaseID: FBgn0038840
• Length: 907
• Species: Drosophila melanogaster
• Sequence 2: NP_498887.2
• Gene: glr-1 / 176204
• WormBaseID: WBGene00001612
• Length: 962
• Species: Caenorhabditis elegans
• Alignment Length: 911
• Identity: 259/911 - (28%)
• Similarity: 434/911 - (47%)
• Gaps: 125/911 - (13%)

  Fly    74 IEPGN--SFETSKKLCKMLRQNLVAVFGPTSNLAARHAMSICDAKELPFLD---------TRWDF 127
            :|.|.  |:.....:|..|::..:|:..............:.||.|:|.:.         .:..|
 Worm    73 VEEGAAVSWNMVNAVCDELKEGAMALLSSVDGKGREGIRGVSDALEMPLVSLTALSNDDHQQQQF 137

  Fly   128 GAQLPTINLHPHPATLGVALRDMVVALGWESFTIIYE---SGEYLPTV-RELLQMYGTAGPTVTV 188
            | .|..:::.|..:.|   |.|.:|..||....::.:   :..:||:: |.|.....|     :|
 Worm   138 G-NLFEVSVRPPISEL---LADFIVHKGWGEVLVLIDPVHASLHLPSLWRHLRTRTNT-----SV 193

  Fly   189 RRYELDLNGNYR---------NVLRRIRNADDFSFVVVGSMATLPEFFKQAQQVGLVTSDYRYII 244
            :....||..:.:         |::|  .|..:...:...|...|.:.....:......::|.|::
 Worm   194 KASMFDLPADEKQFEAYLMQFNMMR--NNETNRILIDCASPKRLKKLLINIRSAQFNQANYHYVL 256

  Fly   245 GNLDWHTMDLEPYQHAGTNITGLRLVSPDSEQVQEVAKALYESEE--PFQNVSCPLT---NSMAL 304
            .|.|:...|.|.:|:...||:|..:::.|..:...:.|.|..|..  ...:||....   ::|.:
 Worm   257 ANYDFLPYDQEMFQNGNINISGFNIINKDGREYWSLKKHLKTSSSLGGGDDVSVEAAVGHDAMLV 321

  Fly   305 VYDGV--------QLLAETYKHVNF--------------------RPVALSCNDDSAWDKGYTLV 341
            .:.|.        .|...|::|..|                    ||.       |:::.|.|:.
 Worm   322 TWHGFAKCLQANDSLFHGTFRHRRFFNRGFPGIYCDPLSDRSHPNRPF-------SSFEHGKTIG 379

  Fly   342 NYMKSLTL----NGLTGPIRFDYEGLRTDFKLEVIEL-----AVSGMQKIGQWSGEDGFQENRPA 397
            ...:::.:    ..|||.|.||..|.|.:|.:.:::|     |....:::..|....||..||..
 Worm   380 VAFRNMKIGHKEGTLTGNIEFDRFGNRKNFDVSIVDLVSNTKATFNSKEVLAWRQGVGFFSNRTV 444

  Fly   398 PAHSLEPDMRSLVNKSFVVITAISEPYGMLKETSEKL------EGNDQFEGFGIELIDELSKKL- 455
            ..|| ........:...:|:|.:..|:.|:|....::      :||::||||.|:|:..|:.|:
 Worm   445 AQHS-RKSQNDHKDNQVIVLTNLVAPFVMIKRECLEMANLTECQGNNKFEGFCIDLLKLLADKIE 508

  Fly   456 GFSYTWRLQEDNKYGGIDPKTGEWNGMLREIIDSRADMGITDLTMTSERESGVDFTIPFMSLGIG 520
            .|:|..:|   ....|.....|.|:||:.|::..||...:..||:..|||..|||:.|||:.||.
 Worm   509 EFNYEIKL---GTKAGSKQADGSWDGMIGELLSGRAHAVVASLTINQERERVVDFSKPFMTTGIS 570

  Fly   521 ILFRKPMKEPPKLFSFMSPFSGEVWLWLGLAYMGVSISMFVLGRLSPAEWDNPYPCIEEPTE--- 582
            |:.:||.|:...:||||.|.|.|:|:::..||:|||:.:|::.|.||.||.     :||.:.
 Worm   571 IMIKKPDKQEFSVFSFMQPLSTEIWMYIIFAYIGVSVVIFLVSRFSPYEWR-----VEETSRGGF 630

  Fly   583 -LENQFSFANCLWFSIGALLQQGSELAPKAYSTRAVAASWWFFTLILVSSYTANLAAFLTVESLV 646
             :.|.||..|||||::.|.:|||:::.|::.|.|..:::|||||:|:|||||||||||||:|.:.
 Worm   631 TISNDFSVYNCLWFTLAAFMQQGTDILPRSISGRIASSAWWFFTMIIVSSYTANLAAFLTLEKMQ 695

  Fly   647 TPINDADDLSKNKGGVNYGAKIGGATFNFFKESNYPTYQRMYEFMRDN-PQYMTNTNQEGVDRVE 710
            .||...:||:| :..:.||.:.||:|.:|||.|:...||||:.:|... |.....:..||::||.
 Worm   696 APIESVEDLAK-QSKIKYGIQGGGSTASFFKYSSVQIYQRMWRYMESQVPPVFVASYAEGIERVR 759

  Fly   711 N--SNYAFLMESTTIEYITERR-CTLTQVGALLDEKGYGIAMRKNWPYRDTLSQAVLEMQEQGLL 772
            :  ..||||:|:|..||...|: |...:|||.|:..|||||......::|.::.|:|.:||:|.|
 Worm   760 SHKGRYAFLLEATANEYENTRKPCDTMKVGANLNSIGYGIATPFGSDWKDHINLAILALQERGEL 824

  Fly   773 TKMKTKWWQEKRGGGACSDA--DEDSGAVALEISNLGGVFLVMGVGSFFGIFVSLLEM-----VL 830
            .|::.|||.::   |.| ||  ..|..:.:|.:|.:.|:|.::..|....:..:|.|.     :.
 Worm   825 KKLENKWWYDR---GQC-DAGITVDGSSASLNLSKVAGIFYILMGGMVISMLAALGEFLYRSRIE 885

  Fly   831 GVKERSDENQVSFKTELLDEIRFILQCSGNTKAVKYPKNSSRSNASSKSKGSSMSVDSLPEDTSE 895
            ..|..|:....:|...|...:...|:.|....||..|.:.|. ||..:.:.::.    ||.:..|
 Worm   886 ARKSNSNSMVANFAKNLKSALSSQLRLSVEGGAVAQPGSQSH-NAIRRQQVAAF----LPANEKE 945

  Fly   896 A 896
            |
 Worm   946 A 946

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Grik	NP_001262788.1	PBP1_iGluR_Kainate	35..395	CDD:380605	74/386 (19%)
		Periplasmic_Binding_Protein_Type_2	411..781	CDD:473866	152/384 (40%)
glr-1	NP_498887.2	PBP1_iGluR_AMPA	32..442	CDD:380603	74/386 (19%)
		Periplasmic_Binding_Protein_Type_2	457..832	CDD:473866	151/383 (39%)