DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Grik and glr-2

DIOPT Version :9

Sequence 1:	NP_001262788.1	Gene:	Grik / 42476	FlyBaseID:	FBgn0038840	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	NP_001021114.1	Gene:	glr-2 / 175999	WormBaseID:	WBGene00001613	Length:	977	Species:	Caenorhabditis elegans

Alignment Length:	962	Identity:	265/962 - (27%)
Similarity:	440/962 - (45%)	Gaps:	216/962 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 NEDLQLHGVSVSIEPGNSFETSKK-------------------LCKMLRQ-----NLVA-----V 97
            |::|.:.|..:.::.|   |||||                   :.:|||.     |.::     |
Worm     2 NKNLLVFGFLIFVKIG---ETSKKFPLRAFVASTDIDNDTAHAIIEMLRLAEMTFNALSDVDFDV 63

  Fly    98 FGPTSNLAARHAMS--------ICDAKELPFL----DTRW-DFG--------AQLPTINLHP--- 138
            ...|.:|......:        |||..:|.::    .|.: ::|        .::|.|:..|
Worm    64 LLGTRDLPPMEMATMMWNLNRIICDEMKLGYMLMLAGTNFKNYGIYEDIANHMKMPLIDWEPSKS 128

  Fly   139 ---------HPATLGVA------LRDMVVALGWESFTIIYESGEYLPTVRELLQMYGTAGPTVTV 188
                     :|....||      |.|.:...||.....|::......|:|.:........|
Worm   129 ENIGKTTENNPMIFSVAPSAEQLLIDYIQYKGWRDVVYIHDGKNADRTLRTMFSYLHEKSP---- 189

  Fly   189 RRYELDLNGNY-------------RNVLRRIR-----NADDFS---------FVVV---GSMATL 223
             :|:|.:: ||             ....|||.     .::|.|         .|:|   ||..|
Worm   190 -KYQLFVD-NYVAPSDEEMFKEFLNEFHRRISTQHTLKSNDSSEEIDEPIPVNVIVDLEGSYRT- 251

  Fly   224 PEFFKQAQQVGLVTSDYRYIIGNLDWHTMDLEPYQHAGTNITGLRLVSPDSEQVQEVAKALYE-S 287
            ..|.:..::..||..:|.|:..|.|....||..:..:..|||..|:...::::..:.....:: .
Worm   252 RAFLRALEESVLVKKEYHYVFSNFDVDETDLSGFHFSLINITIFRIFDKNNKKFLKTRAEFHDVY 316

  Fly   288 EEPFQNVSCPLTNSMALVYDGV--------------------------QLLAETYKHVNFRPVAL 326
            ...|.|.. .:..:.|..:|.:                          ||.....|.:..||
Worm   317 RGGFSNTD-SIPTAAAFAHDAILVAGKALQIAMNEHGKGIFDKSFVRHQLFNRGRKGLYCRP--- 377

  Fly   327 SCNDD-------SAWDKGYTLVNYMKSLTLNG----LTGPIRFD-YEGLRTDFKLEVIEL--AVS 377
              ::|       ..::.|..:...:|.:.|..    |||.|:|| ..|.||:|..|::|:  .|:
Worm   378 --HEDQTESRQFETFEHGKKIAEAIKKVVLTDKDGTLTGRIQFDKVTGKRTNFSAEIVEIKPGVN 440

  Fly   378 GMQKIG---QWSGEDGF--------QENRPAPAHSLEPDMRSLV-NKSFVVITAISEPYGMLKET 430
            .:..|.   ||:..:||        ||.:...:.:.:..:.|.. ...|.|:|.:.:|:.|||..
Worm   441 SLNSIWERFQWAEGEGFLLGGERYVQEKKKDSSQTRKGILPSKPWQLRFNVVTVLVKPFVMLKRR 505

  Fly   431 S---EKLEGNDQFEGFGIELIDELSKKL-GFSYTWRLQEDNKYGGIDPKTGEWNGMLREIIDSRA 491
            :   .:|:|||:|||:.|:|::.|:|.: ||.|...:.:.||||. ....|.|:||:..:::..|
Worm   506 NPGEPELKGNDRFEGYCIDLLNLLAKNITGFEYDVFISDGNKYGS-RQADGSWDGMIGYLLNETA 569

  Fly   492 DMGITDLTMTSERESGVDFTIPFMSLGIGILFRKPMKEPPKLFSFMSPFSGEVWLWLGLAYMGVS 556
            |:.:..||:|.|||..|||:.|||:.||.|:.:||.|:...:||||.|....:|::...:|.|||
Worm   570 DVAVAPLTITQERERAVDFSKPFMTTGISIMIKKPEKQEFNIFSFMEPLGMTIWIFTLSSYFGVS 634

  Fly   557 ISMFVLGRLSPAEWDNPYPCIEEPTELE-------NQFSFANCLWFSIGALLQQGSELAPKAYST 614
            :::|::      .|.:||   |:..|.:       |:|:..|.|||::.|.:|||:::.|:|.|.
Worm   635 LTIFLV------SWFSPY---EKRIEFKRGEFTVTNEFTLYNSLWFTLAAFMQQGTDILPRAVSG 690

  Fly   615 RAVAASWWFFTLILVSSYTANLAAFLTVESLVTPINDADDLSKNKGGVNYGAKIGGATFNFFKES 679
            |..::.|||||||:|||||||||||||:|.:..||...:||: |:..:.||...||:|..||::|
Worm   691 RIASSCWWFFTLIIVSSYTANLAAFLTLERMTPPIESVEDLA-NQNKILYGVNEGGSTAAFFEDS 754

  Fly   680 NYPTYQRMYEFMRD--------NPQYMTNTNQ---------EGVDRVENS--NYAFLMESTTIEY 725
            ..|.|::|:.||..        ..|.:||:..         :|:::|..|  .||||:|.||..|
Worm   755 IVPLYKKMWNFMVSTTQKQIELEKQSITNSTSNRIFVSSYADGIEKVRTSKGKYAFLLEETTNNY 819

  Fly   726 ITERR-CTLTQVGALLDEKGYGIAMRKNWPYRDTLSQAVLEMQEQGLLTKMKTKWWQEKRGGGAC 789
            .:.|| |...:||..|:..|||||.:...|.|.:|:.|:|.:.|:|.|.|::.|||.::   |.|
Worm   820 ESGRRPCDTMKVGQNLNTLGYGIATKIGNPLRVSLNLAILYLSEKGELKKLENKWWYDR---GQC 881

  Fly   790 SDADEDSG-AVALEISNLGGVFLVMGVGSFFGIFVSLLEMVLGVKERSDENQ 840
            .....|.| :.:|.:|.:.|:|.::..|....:..:|:|.:.   .::.||:
Worm   882 DTGTSDGGTSSSLNLSKVAGIFYILLAGMVLSMCTALVEFLF---RKNKENR 930

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Grik	NP_001262788.1	PBP1_iGluR_Kainate	37..391	CDD:107377	92/470 (20%)
		ANF_receptor	53..374	CDD:279440	87/448 (19%)
		Periplasmic_Binding_Protein_Type_2	411..781	CDD:304360	154/400 (39%)
		Lig_chan	543..816	CDD:278489	109/300 (36%)
glr-2	NP_001021114.1	Periplasmic_Binding_Protein_Type_1	7..453	CDD:299141	90/461 (20%)
		Periplasmic_Binding_Protein_Type_2	491..875	CDD:304360	152/394 (39%)
		Lig_chan	621..910	CDD:278489	109/301 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.920