DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Grik and glr-4

DIOPT Version :9

Sequence 1:	NP_001262788.1	Gene:	Grik / 42476	FlyBaseID:	FBgn0038840	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	NP_001254126.1	Gene:	glr-4 / 174258	WormBaseID:	WBGene00001615	Length:	951	Species:	Caenorhabditis elegans

Alignment Length:	951	Identity:	279/951 - (29%)
Similarity:	458/951 - (48%)	Gaps:	147/951 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 GF-ILTSLLLAFPGCRGERTNVGLV-------YENTDPDLEKIFHL--AISKANEENEDLQLHGV 70
            || ||..:.........:|.::|.:       ||          ||  ||.:.|.|      ||.
Worm    10 GFSILLVIFYIANSAADDRFHIGTIANRGSFAYE----------HLRYAIDRWNTE------HGA 58

  Fly    71 SVSIE-----P---GNSFETSKKLCKMLRQNLVAVF--GPTSNLAARHAMSICDAKELPFL---- 121
            ...|:     |   .|::|  :::|::::|.:|||.  ...|...::...|:|....:|.|
Worm    59 HTQIKFSIVSPIRYDNNYE--ERMCEIMQQGIVAVVLSNEESEQDSQLIKSMCHYFNIPCLSLQS 121

  Fly   122 ----DTRWDFGAQLPTINLHPHPATLGVALRDMVVALGWESFTIIYESGEYLPTVRELL---QMY 179
                |:..||     ...|.|.......|..:.:.::.|..|.:.|:.|..|..:..|:   |:.
Worm   122 TSLRDSVSDF-----VTLLGPSRGAGARATSEFLDSMRWTGFLLAYQHGSDLEDLSPLMQYKQIV 181

  Fly   180 GTAGPTVTVRRYELDLN-GNYRNVLRRIRNADDFSFVVVGS--MATLPEFFKQAQQVGLVTSDYR 241
            .|.|..:.::...|..| .:|...|:.::.....:.:::.|  :..|....:||:.:.:....:.
Worm   182 DTGGRRIHIKIRRLPNNTDDYEPFLKYVKTRLKQTNIIIHSNNITVLYNLLQQARGLNMAEPPFS 246

  Fly   242 YIIGNLDWHTMD--LEPYQHAG--TNITGLRLVSPD----------SEQVQEVAKALYESEE--- 289
            |:..|.|...::  |.....|.  .|||||:||..|          ||.|..|..::|...|
Worm   247 YVFTNTDLSLLEDFLNNMYGASFHCNITGLQLVKNDPMMKTQLALTSEAVYVVGMSIYRMRELGH 311

  Fly   290 -PFQNVSCPLTNSMALVYDGVQLLAETYKHVNFRPVALSCNDDSAWDKGYTLVNYMKSLTL-NGL 352
             |.|:                               ::.|:....|..|..:...::.|.| |.|
Worm   312 APRQS-------------------------------SIMCDSHDIWSDGRIMNEGIRKLKLRNQL 345

  Fly   353 TGPIRFDYEGLRTDFKLEVIELAVSGMQKIGQWSGEDGFQ-ENRPAP--AHSLEPDMRSLVNKSF 414
            ||.::|...|.|.|.....:....|...|:|.||.:.|:. ::|.|.  ...::||...|.....
Worm   346 TGDVQFKSNGERDDIMYHGVGRINSQFVKLGNWSEKRGWNFDSRYANRWEFDIDPDSEDLEGLHL 410

  Fly   415 VVITAISEPYGMLKETSEKLEGNDQFEGFGIELIDELSKKLGFSYTWRLQEDNKYGGIDPKTGEW 479
            .|:..:.||: ::|      .|.:|:|||.|:|::|:::.|.|:||....:|..| ||:.::|.|
Worm   411 RVVVYLEEPF-VIK------TGENQYEGFCIDLLNEMTQVLKFNYTIIEVQDGTY-GIEDESGRW 467

  Fly   480 NGMLREIIDSRADMGITDLTMTSERESGVDFTIPFMSLGIGILFRKPMKEPPK--LFSFMSPFSG 542
            ||::..:....||:.::.:|:|..|...||||:|||.|||.||..:..:|..|  |::|:.|.|.
Worm   468 NGIIGALQRHEADLSLSAVTITYSRAEVVDFTLPFMHLGISILLARTSEETDKGSLWTFLEPLSL 532

  Fly   543 EVWLWLGLAYMGVSISMFVLGRLSPAEWDNPYPCIEEPTE----LENQFSFANCLWFSIGALLQQ 603
            .||:.|.::|..||.||.:|.:.||.||.|.....|...|    .:|||:..|..||::|:|:||
Worm   533 TVWISLLISYCIVSYSMHILAKFSPYEWYNLERIDERDFENIKNQKNQFTVLNSFWFTMGSLMQQ 597

  Fly   604 GSELAPKAYSTRAVAASWWFFTLILVSSYTANLAAFLTVESLVTPINDADDLSKNKGGVNYGAKI 668
            ||::.|:|.:||.:|..||.||.|::|||||.||||||||.:.|||....||: |:..:.||...
Worm   598 GSDVIPRAAATRLIAVVWWMFTQIIISSYTAQLAAFLTVERMSTPIESTQDLA-NQQKIRYGVLK 661

  Fly   669 GGATFNFFKESNYPTYQRMYEFMR-DNPQYMTNTNQEGVDRVENSNYAFLMESTTIEYITERRCT 732
            .|:|.:||:||..|.|:||:..|. .:|....|:::||:.||::..||::|||:.:||..||.|.
Worm   662 SGSTMDFFRESKIPMYERMWSVMESSSPGVFVNSSREGIARVKSGGYAYMMESSMLEYYLERDCE 726

  Fly   733 LTQVGALLDEKGYGIAMRKNWPYRDTLSQAVLEMQEQGLLTKMKTKWWQEKRGGGACSDADEDSG 797
            |..:|.|||.||||||:.|..|.||.||:.||::||:.:|..:|.|||:::|.|.:|.....:.
Worm   727 LQSIGGLLDSKGYGIALPKGSPLRDILSRTVLQLQERTILEALKNKWWRDRREGPSCGPPPSEK- 790

  Fly   798 AVALEISNLGGVFLVMGVGSFFGIFVSLLEMVLGVKERSDENQVSFKTELLDEIRFILQCSGNTK 862
            |...:..|:.|:|.|:..|......::..|..:      :....:|:.:|....:|:....||:
Worm   791 ATNSKPQNIFGIFYVLLTGLIVAFLLACGEYCI------ESRHEAFRLKLTIVGKFMDWYRGNS- 848

  Fly   863 AVKYPKNSSRSNASSKSKGSSMSVDSLPEDTSEADASGKHN 903
                      :::..:||..:|.:|:..::.|   .|.:|:
Worm   849 ----------NDSKQRSKLRNMQLDTAGQEVS---ISTRHD 876

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Grik	NP_001262788.1	PBP1_iGluR_Kainate	37..391	CDD:107377	87/405 (21%)
		ANF_receptor	53..374	CDD:279440	78/365 (21%)
		Periplasmic_Binding_Protein_Type_2	411..781	CDD:304360	158/376 (42%)
		Lig_chan	543..816	CDD:278489	120/277 (43%)
glr-4	NP_001254126.1	PBP1_iGluR_Kainate	30..385	CDD:107377	88/408 (22%)
		ANF_receptor	45..365	CDD:279440	78/363 (21%)
		Periplasmic_Binding_Protein_Type_2	410..775	CDD:304360	158/373 (42%)
		Lig_chan	533..810	CDD:278489	120/278 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	1	1.010	-	-		D60688at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		otm14234
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.930