Protein Alignment Grik and nmr-1

DIOPT Version :10

• Sequence 1: NP_001262788.1
• Gene: Grik / 42476
• FlyBaseID: FBgn0038840
• Length: 907
• Species: Drosophila melanogaster
• Sequence 2: NP_495033.2
• Gene: nmr-1 / 173929
• WormBaseID: WBGene00003774
• Length: 1025
• Species: Caenorhabditis elegans
• Alignment Length: 895
• Identity: 216/895 - (24%)
• Similarity: 365/895 - (40%)
• Gaps: 173/895 - (19%)

  Fly    65 LQL-----HGVSVSIEPGNSFETSKKLCKMLRQNLVAVFGPTSNLAARHAMS--ICDAKELPFLD 122
            |||     :.|||.|....:.||.|:|...:....|.|||.||.......:|  ..|||.   .|
 Worm    13 LQLGYTIDYKVSVLIVSEPNQETFKELKVSVTAAFVEVFGSTSYHLGNDTISAAFVDAKS---GD 74

  Fly   123 TRWDFGAQLPTINLHPHP---------ATLGVALRDMVVALGWESFTIIYESGEYLPTVRELLQ- 177
            .|.:....:....:..|.         .|......|:|.:   .::|:.:..   ||.|..:::
 Worm    75 NRLELTQDIVCSQMLNHSLASVIFSPLLTSSSRFIDLVTS---SAYTLSFYK---LPVVGVMVRD 133

  Fly   178 -------MYGT-AGPTVTVRR-----YELDLNGNYRNV----LRRIRNADDFSFVVVGSMATLPE 225
                   :|.| ..||..:..     ..:.|:..||.|    ::|..|||.|          :.|
 Worm   134 AEFSKKNIYPTFVRPTAPLSDEAFVFLHMLLSLKYRQVVVLSVKRDINADQF----------VEE 188

  Fly   226 FFKQAQQVGLVTSDYRYIIGNLDWHTMD--LEPYQHAGTNITGLRLVSPDSEQVQEVA------- 281
            |.|:..:..::..  |||...|:.:..|  .|.::...:||..|.....|:.::...|
 Worm   189 FEKRRVEFKIIVQ--RYIEVELNENLNDTLAESFEEVTSNIIVLFAKKDDAVRIFANAGDLTGKG 251

  Fly   282 KALYESEE-------PFQNVSC--------PLTNSMALVYDGVQLLAETYKHVNFRPVALSCNDD 331
            |....||.       |..::.|        .|.:|.:::...::.:....|...|.||  .|:.|
 Worm   252 KVWIVSESAGEAHNVPNGSLGCRLGQTAFSVLRDSFSILKSAMETIFRESKIDIFPPV--ECDRD 314

  Fly   332 SA---WD--KGYTLVNYMKSLTLNGLTGPIRFDYEGLRTDFKLEVIELAVSGMQKIGQWSG---- 387
            |.   |:  :...|:|.:...:    |..:.|:.:..|...:.::|...:...| :|...|
 Worm   315 SVDAEWNSLQAPALLNEICGTS----TSRVHFNDKCERIGVEYDIINFHMERKQ-VGNMVGDILR 374

  Fly   388 --EDGFQ---ENRPAPAHSLEPDMR--SLVNKSFVVITAISEPYGMLKETSE------------- 432
              ||..:   ..:|... ||...:|  ::.:..||..|.|..|    .:.:|
 Worm   375 LDEDSIEWAGGTKPLEI-SLPKHLRVVTVADPPFVYTTPIGSP----SQCAELGNTVVEWSIFDK 434

  Fly   433 ------------KLEGNDQF---EGFGIELIDELS-----KKLGFSYTWRLQEDNKYGGIDPK-- 475
                        .||.:.::   .|..|:|:..||     ..:..|:|:.|..:..||.:...
 Worm   435 IVVSGPWYSCPLTLENSTEYFCCAGLAIDLLSNLSLPEANNSIDTSFTFSLHLNESYGVVQASET 499

  Fly   476 TG-EWNGMLREIIDSRADMGITDLTMTSERESGVDFTIPFMSLGIGILFRKPMKEPPKLFSFMSP 539
            || ..:|::.|:....|||.|..:|:..|||..||||.|::..||.||.:...::.| :.||:.|
 Worm   500 TGITISGVIGELDGDTADMAIGGITINPERERIVDFTEPWLYHGIRILEKNIPRDSP-MQSFLQP 563

  Fly   540 FSGEVWLWLGLAYMGVSISMFVLGRLSPAEWDNPYPCIEE-PTELENQF------------SFAN 591
            ....:|..|.::.:.|.::::.|...||  ::..|...:| ..:|:.:|            :|..
 Worm   564 LQSSLWTALFISVILVGLAIYCLDFKSP--FERFYQADKEMEQDLKKEFELWIGKDADENVNFGE 626

  Fly   592 CLWFSIGALLQQG-SELAPKAYSTRAVAASWWFFTLILVSSYTANLAAFLTV---ESLVTPINDA 652
            .:||..|.||..| ||..|::.|.|.:...|..|.:|:|:||||||||||.:   |..:|.:.|
 Worm   627 AMWFVWGVLLNSGVSEKTPRSCSARVLGIVWCGFCMIMVASYTANLAAFLVLDQPEKGLTGVTD- 690

  Fly   653 DDLSKNKGGVNYGAKIGGATFNFFKESNYPTYQRMYEFMRDNPQYMTNTNQEGVDRVENSNY-AF 716
            ..|.......::|..:....:.:||.     :..:....|....:......|.|..:.|.:. ||
 Worm   691 PRLRNPSANFSFGTVLNSNVYQYFKR-----HVELSSMFRKMEPHNVRRASEAVHSLLNGSLDAF 750

  Fly   717 LMESTTIEYITERRCTLTQVGALLDEKGYGIAMRKNWPYRDTLSQAVLEMQEQGLLTKMKTKWWQ 781
            :.:||.:|:...|.|.|...|:|.....|||.::||.|:...::.|:|.|.|.|::.|:..||..
 Worm   751 IWDSTRLEFEAARHCELRTRGSLFGRSAYGIGLQKNSPWTPHITSAILRMSESGVMEKLDQKWID 815

  Fly   782 EKRGGGACSDADEDSGAVALEISNLGGVFLVMGVGSFFGIFVSLLEMVLG 831
              |||..|. .:.......|.:.|:..:|:::..|...|||:|.:|:..|
 Worm   816 --RGGPNCV-VEAHKSPARLGLVNMKDIFILVSSGVALGIFLSFVEVSYG 862

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Grik	NP_001262788.1	PBP1_iGluR_Kainate	35..395	CDD:380605	84/401 (21%)
		Periplasmic_Binding_Protein_Type_2	411..781	CDD:473866	114/423 (27%)
nmr-1	NP_495033.2	Periplasmic_Binding_Protein_type1	19..384	CDD:471960	81/392 (21%)
		PBP2_iGluR_NMDA_Nr1	394..822	CDD:270437	118/442 (27%)
		Lig_chan	566..844	CDD:459656	78/288 (27%)
		LITAF	949..1017	CDD:197841