DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Grik and glr-3

DIOPT Version :9

Sequence 1:	NP_001262788.1	Gene:	Grik / 42476	FlyBaseID:	FBgn0038840	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	NP_492017.3	Gene:	glr-3 / 172449	WormBaseID:	WBGene00001614	Length:	836	Species:	Caenorhabditis elegans

Alignment Length:	810	Identity:	249/810 - (30%)
Similarity:	413/810 - (50%)	Gaps:	81/810 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 VSVSIEPGNSFETSKKLCKMLRQNLVAVFGPTSN----LAARHAMSICDAKELPFLD------TR 124
            |.:|||.|     ...:|..|.....|:..|...    .||....||.|...:|.:.      ||
Worm    64 VGISIENG-----LFSVCNCLILGASAIILPEQYDGHLAAAAIVQSIADNTNVPCVSLHLSPPTR 123

  Fly   125 WDFGAQLPTINLHPHPATLGVALRDMVVALGWESFTIIYESGEYLPTVRELLQMYGTAG----PT 185
                   |:.:||||.....:|:...:....|:...:::|..:.|..:.:::    |||    .:
Worm   124 -------PSTHLHPHLNAKSLAVAAFIKREKWKDVVVVFEEPDELLEITDMI----TAGHFDPDS 177

  Fly   186 VTVRRYELDLNGNYRNVLRRIRN-ADDFSFVVVGSMATLPEFFKQAQQVGLVTSDYRYIIGNLDW 249
            .:.:...|....:|.|.|:.|:| .|.:..|:...:.....|.:||..:.:....|.|::.::|.
Worm   178 FSSQLVRLKHGDDYGNELKHIKNKLDRYRIVINIPLQKALHFLEQAANMSMCGVLYHYVVMDMDL 242

  Fly   250 HTMDLEPYQH-AGTNITGLRLVSPDSEQVQEVAKAL-YESEEPFQNVSCPLTNSMALVYDGVQLL 312
            .|:|::..:. ...|||...:...:||.::::.:.: ::|.........|.|.|:.:  |.::||
Worm   243 VTVDIDSIRGIEDCNITSFGVHDVNSEYIEDIRQEIVHKSSIRLPKKGVPYTTSIWI--DTLRLL 305

  Fly   313 AETYKHVNF--RPVALSCNDDSAWDKGYTLVNYMKSLTLNGLTGPIRFDYEGLRTDFKLEVIELA 375
            ..:.|.:..  .|   .|.  |:|..|..:........|.|::|.:.:...|.|:::.|.|....
Worm   306 IRSMKSIQIWDEP---RCG--SSWKSGSDIKKRFFENPLAGISGDLHWAPSGERSNYTLHVYRRT 365

  Fly   376 VSGMQKIGQWSGEDGFQENRPAPAHSLEPDMRSLVNKSFVVITAISEPYGMLKETSEKLEGNDQF 440
            :| .||..:||.......:..|...:...:..:|..|...:...:..|:.|:  ||     |..:
Worm   366 LS-FQKFAEWSSRTRRIASSEAVVIANSSEKLTLEGKHLKISVYLEAPFVMI--TS-----NGSY 422

  Fly   441 EGFGIELIDELSKKLGFSYTWRLQEDNKYGGIDPKTGEWNGMLREIIDSRADMGITDLTMTSERE 505
            ||:.|:|:.:::..|.|:||.:...||.||..: ..|:|:||:.|:....||:.:..||::..|.
Worm   423 EGYCIDLLHKIANILKFTYTIQKVRDNAYGSKE-SNGKWSGMVGELQRGDADLAVASLTISYGRS 486

  Fly   506 SGVDFTIPFMSLGIGILFRKPMKEPPKLFSFMSPFSGEVWLWLGLAYMGVSISMFVLGRLSPAEW 570
            ..:|||:|:|.|||.|||:||.......|.||.|.|.:||:....:|..||::::::.::||.|.
Worm   487 EVIDFTVPYMHLGISILFKKPRIRDSDWFKFMDPLSTQVWIMTFASYFVVSVAIWIIAKISPYEQ 551

  Fly   571 -----DNPYPCIEEPTELENQFSFANCLWFSIGALLQQGSELAPKAYSTRAVAASWWFFTLILVS 630
                 ||     .:...::||||..|..||::.:|:||||||.|:|.|||.:...||||.|||:|
Worm   552 FERDEDN-----GQYKPVDNQFSLRNSFWFTVCSLMQQGSELCPRAASTRLLTGIWWFFALILIS 611

  Fly   631 SYTANLAAFLTVESLVTPINDADDLSKNKGGVNYGAKIGGATFNFFKESNYPTYQRMYEFMRDNP 695
            ||||||||.||...:.|||.:||||:. :..:.||....|:|.:||.||...||:||::.|..:|
Worm   612 SYTANLAAVLTTRRMETPIENADDLAA-QTKIKYGTLGRGSTMSFFNESKIETYERMWQLMSSSP 675

  Fly   696 QYMTNTNQEGVDRVENSNYAFLMESTTIEYITERRCTLTQVGALLDEKGYGIAMRKNWPYRDTLS 760
            .....:::||:.||::|:||:||||:.:||..||.|.|.|:|.|:|:|||||.:.|..|||:.:|
Worm   676 GLFVQSSKEGIARVKSSDYAYLMESSMLEYAVERDCELMQIGGLIDQKGYGIGLPKGSPYRELIS 740

  Fly   761 QAVLEMQEQGLLTKMKTKWWQEKRGGGACSD---ADEDSGAVALEISNLGGVFLVMGVGSFFGIF 822
            .|:|.:||:..||::|.|||::|  ...|..   .|:|.|      .::||:|:::.||......
Worm   741 TAILRLQEKTELTELKEKWWKDK--SVVCEQPKRKDQDDG------ESIGGIFIILVVGLVLTAV 797

  Fly   823 VSLLEMVLGVKERSDENQV--------SFK 844
            :.:.|::...|....::||        |||
Worm   798 LVIFELITTRKPSPAQSQVIRHVNVIPSFK 827

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Grik	NP_001262788.1	PBP1_iGluR_Kainate	37..391	CDD:107377	75/339 (22%)
		ANF_receptor	53..374	CDD:279440	70/322 (22%)
		Periplasmic_Binding_Protein_Type_2	411..781	CDD:304360	154/374 (41%)
		Lig_chan	543..816	CDD:278489	117/280 (42%)
glr-3	NP_492017.3	PBP1_iGluR_non_NMDA-like	21..385	CDD:380591	75/344 (22%)
glr-3	NP_492017.3	Periplasmic_Binding_Protein_Type_2	401..761	CDD:419667	154/373 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3952
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D60688at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		otm14234
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.870