DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Grik and Grin3b

DIOPT Version :9

Sequence 1:	NP_001262788.1	Gene:	Grik / 42476	FlyBaseID:	FBgn0038840	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	NP_579842.2	Gene:	Grin3b / 170796	RGDID:	621705	Length:	1002	Species:	Rattus norvegicus

Alignment Length:	938	Identity:	207/938 - (22%)
Similarity:	347/938 - (36%)	Gaps:	219/938 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 LRQNLVAVFGPTSNLAARHAMSICDAKELPFLDTRWDFGAQLPTINLHPHPA------TLGVALR 148
            |...||||..||.:.|:. |..:|.....|.:.....|....|.:.|....|      .:.|..|
  Rat    70 LSLELVAVASPTRDPASL-ARGLCQVLAPPGVVASIAFPEARPELRLLQFLAAATETPVVSVLRR 133

  Fly   149 DMVVALGWES-FTIIYESGEYLPTVRELLQMYGTAGPTVTVRRYELDLNGNYRNVLRRIRNADDF 212
            ::..|||..: |.:..:....|.|:.::|        ...||.:..:   :...||.|:|:.
  Rat   134 EVRTALGAPTPFHLQLDWASPLETILDVL--------VSLVRAHAWE---DIALVLCRVRDP--- 184

  Fly   213 SFVVVGSMATL--------PEFFKQAQQVGLVTSDYR---YIIGNLDWHTMDLEPYQHAGTNITG 266
                 ||:.||        |:|.....::.......|   .::|.|          :..||.:..
  Rat   185 -----GSLVTLWTNHASQAPKFVLDLSRLDSRNDSLRAGLALLGAL----------EGGGTPVPA 234

  Fly   267 LRLVSPDSEQVQEVAKALYESEE-----PFQNVSCPLT--------------NSM-ALVYDGVQL 311
            ..|:...:.:..||.:|.....:     |....:.|.|              :|: |:|:|.|:|
  Rat   235 AVLLGCSTARAHEVLEAAPPGPQWLLGTPLPAEALPTTGLPPGVLALGETEQHSLEAVVHDMVEL 299

  Fly   312 LAETYKHV-------NFRPVALSCND---DSAWDKGYTLVNYMKSLTLNGLTGPI---------- 356
            :|:....:       ...|..::|:|   ..:...|.||..::.:.:..|.||.:
  Rat   300 VAQALSSMALVHPERALLPAVVNCDDLKTGGSEATGRTLARFLGNTSFQGRTGAVWVTGSSQVHV 364

  Fly   357 --RFDYEGLRTDFKLEVIELAVSGMQKIGQW-SGEDGFQENR-----PAPAHS-LEPDMRSLVNK 412
              .|....||.|      .|.......:|.| .|:..||...     |:|:.: ..|.:|
  Rat   365 SRHFKVWSLRRD------PLGAPAWATVGSWQDGQLDFQPGAAALRVPSPSGTQARPKLR----- 418

  Fly   413 SFVVITAISEPYGMLKETSEKLEG-------------NDQFE----------------------G 442
               |:|.:..|:...:|:.|  :|             ||...                      |
  Rat   419 ---VVTLVEHPFVFTRESDE--DGQCPAGQLCLDPGTNDSARLDALFAALVNGSVPRTLRRCCYG 478

  Fly   443 FGIELIDELSKKLGFSYTWRLQEDNKYGGIDPKTGEWNGMLREIIDSRADMGITDLTMTSERESG 507
            :.|:|::.|::.|.|.:...:..|.|||.:  :.|.|.|::.:::..||.|.:|..::.|.|...
  Rat   479 YCIDLLERLAEDLAFDFELYIVGDGKYGAL--RDGRWTGLVGDLLAGRAHMAVTSFSINSARSQV 541

  Fly   508 VDFTIPFMSLGIGILFRKPMKEPPKLFSFMSPFSGEVWLWLGLAYMGVSISMFVLGR-LSPAEWD 571
            ||||.||.|..:||:.|......| :.:||.|....:|       :||..::.:... |:..||.
  Rat   542 VDFTSPFFSTSLGIMVRTRDTASP-IGAFMWPLHWSMW-------VGVFAALHLTALFLTLYEWR 598

  Fly   572 NPYPCIEEPTELENQFSFANCLWFSIGALL-QQGSELAPKAYSTRAVAASWWFFTLILVSSYTAN 635
            :||............||:::.|......|. :..|...||..:.|.:...|..|.|:::||||||
  Rat   599 SPYGLTPRGRNRGTVFSYSSALNLCYAILFGRTVSSKTPKCPTGRFLMNLWAIFCLLVLSSYTAN 663

  Fly   636 LAAFLTVESLVTPINDADD--LSKNKGGVNYGAKIGGATFNFFKESNYPTYQRMYEFMRDNPQYM 698
            |||.:..:.....::...|  |.....|..:|.....:...:.|.|    :..|:..||   ::.
  Rat   664 LAAVMVGDKTFEELSGIHDPKLHHPSQGFRFGTVWESSAEAYIKAS----FPEMHAHMR---RHS 721

  Fly   699 TNTNQEGVDRVENSN---YAFLMESTTIEY--ITERRCTLTQVGALLDEKGYGIAMRKNWPYRDT 758
            ..|...||..:.:..   .||:|:.:.::|  ..:..|.|..||.....:||||.:.:|.|....
  Rat   722 APTTPHGVAMLTSDPPKLNAFIMDKSLLDYEVSIDADCKLLTVGKPFAIEGYGIGLPQNSPLTSN 786

  Fly   759 LSQAVLEMQEQGLLTKMKTKWWQEKRGGGACSDADEDSGAVALEISNLGGVFLVMGVGSFFGIFV 823
            ||:.:...:..|.:..:..||::....|.......|.               |.|||..|.|:||
  Rat   787 LSEFISRYKSSGFIDLLHDKWYKMVPCGKRVFAVTET---------------LQMGVYHFSGLFV 836

  Fly   824 SLLEMVLGVKERSDENQVSFKTELLDEIRFILQCSGNTKAVKY---------------PKNSSRS 873
             ||.:.||....:...:..|...:|..||     .||  .::|               |....:.
  Rat   837 -LLCLGLGSALLTSLGEHVFYRLVLPRIR-----RGN--KLQYWLHTSQKIHRALNTGPPEGQQE 893

  Fly   874 NASSKSKGSSMSVDSLPEDTSEADASGK 901
            .|..:..|..   |.||    ..|.:|:
  Rat   894 RAEQERSGPK---DELP----ATDGAGR 914

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Grik	NP_001262788.1	PBP1_iGluR_Kainate	37..391	CDD:107377	72/361 (20%)
		ANF_receptor	53..374	CDD:279440	68/343 (20%)
		Periplasmic_Binding_Protein_Type_2	411..781	CDD:304360	100/413 (24%)
		Lig_chan	543..816	CDD:278489	64/281 (23%)
Grin3b	NP_579842.2	PBP1_iGluR_NMDA_NR3	21..405	CDD:107372	74/370 (20%)
		PBP2_iGluR_NMDA_Nr3	414..808	CDD:270438	101/420 (24%)
		Lig_chan	576..842	CDD:278489	71/295 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	882..910		6/34 (18%)
		Involved in the trafficking and surface expression of NMDARs. /evidence=ECO:0000250	951..984
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349882
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840