DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Grik and Grin3b

DIOPT Version :9

Sequence 1:	NP_001262788.1	Gene:	Grik / 42476	FlyBaseID:	FBgn0038840	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	XP_006513350.1	Gene:	Grin3b / 170483	MGIID:	2150393	Length:	1138	Species:	Mus musculus

Alignment Length:	926	Identity:	202/926 - (21%)
Similarity:	346/926 - (37%)	Gaps:	184/926 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    83 SKKLCKMLRQNLVAVFGPTSNLAARHAMSICDAKELPFLDTRWDFGAQLPTINLHPHPA------ 141
            |.:|...|...||||..||.:.|:. |..:|.....|.:.....|....|.:.|....|
Mouse   143 SPRLPHNLSLELVAVASPTRDPASL-ARGLCQVLAPPGVVASITFPEARPELRLLQFLAAATETP 206

  Fly   142 TLGVALRDMVVALGWES-FTIIYESGEYLPTVRELLQMYGTAGPTVTVRRYELDLNGNYRNVLRR 205
            .|.|..|::...||..: |.:..:....|.|:.::|        ...||.:..:   :...||.|
Mouse   207 VLSVLRREVRAPLGAPTPFHLQLDWASPLETILDVL--------VSLVRAHAWE---DIALVLCR 260

  Fly   206 IRNADDFSFVVVGSMATLPEFFKQAQQVGLVTSDYR---YIIGNLDWHTMDLEPYQHAGTNITGL 267
            :|:......:.....:..|:|.....|:.......|   .::|.|          :..||.::..
Mouse   261 VRDPSGLVTLWTSRASQAPKFVLDLSQLDSGNDSLRATLALLGTL----------EGGGTPVSAA 315

  Fly   268 RLVSPDSEQVQEVAKALYESEE-----PFQNVSCPLT---------------NSMALVYDGVQLL 312
            .|:...:....||.:|.....:     |....:.|.|               :..|.|:|.|:|:
Mouse   316 VLLGCSTAHAHEVLEAAPPGPQWLLGTPLPAEALPKTGLPPGVLVLGETGQPSLEAAVHDMVELV 380

  Fly   313 AETYKHVNFR-------PVALSCND---DSAWDKGYTLVNYMKSLTLNGLTGPI----------- 356
            |.....:...       |.|::|.|   ..:.....||..::.:.:..|.||.:
Mouse   381 ARALSSMALMHPERALLPAAVNCEDLKTGGSESTARTLARFLSNTSFQGRTGAVWVAGSSQVHVS 445

  Fly   357 -RFDYEGLRTDFKLEVIELAVSGMQKIGQW-SGEDGFQENR-----PAPAHS-LEPDMRSLVNKS 413
             .|....||.|      .|.......:|.| .|:..||...     |:|:.: ..|.:|
Mouse   446 RHFKVWSLRRD------PLGAPAWATVGSWQDGQLDFQPGAAALRVPSPSGTQARPKLR------ 498

  Fly   414 FVVITAISEPYGMLKETSEKLEG-------------NDQFE----------------------GF 443
              |:|.:..|:...:|:.|  :|             ||...                      |:
Mouse   499 --VVTLVEHPFVFTRESDE--DGQCPAGQLCLDPGTNDSARLDALFTALENGSVPRTLRRCCYGY 559

  Fly   444 GIELIDELSKKLGFSYTWRLQEDNKYGGIDPKTGEWNGMLREIIDSRADMGITDLTMTSERESGV 508
            .|:|::.|::.|.|.:...:..|.|||.:  :.|.|.|::.:::..||.|.:|..::.|.|...|
Mouse   560 CIDLLERLAEDLAFDFELYIVGDGKYGAL--RDGRWTGLVGDLLAGRAHMAVTSFSINSARSQVV 622

  Fly   509 DFTIPFMSLGIGILFRKPMKEPPKLFSFMSPFSGEVWLWLGLAYMGVSISMFVLGR-LSPAEWDN 572
            |||.||.|..:||:.|......| :.:||.|....:|       :||..::.:... |:..||.:
Mouse   623 DFTSPFFSTSLGIMVRTRDTASP-IGAFMWPLHWSMW-------VGVFAALHLTALFLTLYEWRS 679

  Fly   573 PYPCIEEPTELENQFSFANCLWFSIGALL-QQGSELAPKAYSTRAVAASWWFFTLILVSSYTANL 636
            ||............||:::.|......|. :..|...||..:.|.:...|..|.|:::|||||||
Mouse   680 PYGLTPRGRNRGTVFSYSSALNLCYAILFGRTVSSKTPKCPTGRFLMNLWAIFCLLVLSSYTANL 744

  Fly   637 AAFLTVESLVTPINDADD--LSKNKGGVNYGAKIGGATFNFFKESNYPTYQRMYEFMRDNPQYMT 699
            ||.:..:.....::...|  |.....|..:|.....:...:.|.|    :..|:..||   ::..
Mouse   745 AAVMVGDKTFEELSGIHDPKLHHPSQGFRFGTVWESSAEAYIKAS----FPEMHAHMR---RHSA 802

  Fly   700 NTNQEGVDRVENSN---YAFLMESTTIEY--ITERRCTLTQVGALLDEKGYGIAMRKNWPYRDTL 759
            .|...||..:.:..   .||:|:.:.::|  ..:..|.|..||.....:||||.:.:|.|....|
Mouse   803 PTTPHGVAMLTSDPPKLNAFIMDKSLLDYEVSIDADCKLLTVGKPFAIEGYGIGLPQNSPLTSNL 867

  Fly   760 SQAVLEMQEQGLLTKMKTKWWQEKRGGGACSDADEDSGAVALEISNLGGVFLVMGVGSFFGIFVS 824
            |:.:...:..|.:..:..||::....|.......|   .:.:.:.:|.|:|:::.:|....:..|
Mouse   868 SEFISRYKSSGFIDLLHDKWYKMVPCGKRVFAVTE---TLQMGVYHLSGLFVLLCLGLGSALLTS 929

  Fly   825 LLEMVLGVKERSDENQVSFKTELLDEIRFILQCSGNTKAVKYPKNSSRSNASSKSKGSSMSVDSL 889
            |.|.|             |...:|..||     .||  .::|..::|:.....|.......:.||
Mouse   930 LGEHV-------------FYRLVLPRIR-----RGN--KLQYWLHTSQVRRQDKVGRGGGHLRSL 974

  Fly   890 PEDTS---EADASGKH 902
            |:..|   |...|.:|
Mouse   975 PKHLSVPLEDPPSPQH 990

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Grik	NP_001262788.1	PBP1_iGluR_Kainate	37..391	CDD:107377	70/360 (19%)
		ANF_receptor	53..374	CDD:279440	66/342 (19%)
		Periplasmic_Binding_Protein_Type_2	411..781	CDD:304360	100/413 (24%)
		Lig_chan	543..816	CDD:278489	64/281 (23%)
Grin3b	XP_006513350.1	PBP1_iGluR_NMDA_NR3	141..481	CDD:380600	72/365 (20%)
		PBP2_iGluR_NMDA_Nr3	494..888	CDD:270438	101/420 (24%)
		Lig_chan	656..922	CDD:365843	64/282 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846398
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840