DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Grik and gria3a

DIOPT Version :9

Sequence 1:	NP_001262788.1	Gene:	Grik / 42476	FlyBaseID:	FBgn0038840	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	XP_005165152.1	Gene:	gria3a / 170452	ZFINID:	ZDB-GENE-020125-5	Length:	903	Species:	Danio rerio

Alignment Length:	877	Identity:	286/877 - (32%)
Similarity:	446/877 - (50%)	Gaps:	103/877 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 WFVKMISTEASFPLGFILTSLLLAFPGCRGERTNVGLVYENTDPDL-EKIFHLAISKANEENEDL 65
            |.|  :.|:|.||....:..|.:.............:...||:.:: ||.|||   ..|.:|
Zfish    14 WLV--LQTQAGFPNQINIGGLFMRSTVQEHSAFRFAVQLYNTNQNITEKPFHL---NYNVDN--- 70

  Fly    66 QLHGVSVSIEPGNSFETSKKLCKMLRQNLVAVFGPTSNLAARHAMSICDAKELPFL------DTR 124
                    :|..|||..:...|....:.:.|:||.....:.....|.|.|....|:      ||.
Zfish    71 --------LESSNSFSVTHAFCSQFSRGVYAIFGFYDRRSMNTLTSFCGALHTSFITPSFPTDTD 127

  Fly   125 WDFGAQLPTINLHPHPATLGVALRDMVVALGWESFTIIYESGEYLPTVRELLQMYGTAGPTVTVR 189
            ..|..|:       .|:..| ||..::....||.|..:|::......::.:::........||.|
Zfish   128 VQFVLQM-------RPSLRG-ALLSLLAHYKWEKFVYLYDTDRGFSILQAIMESAVMNNWQVTAR 184

  Fly   190 RYELDLNGN------YRNVLRRIRNADDFSFVVVGSMATLPEFFKQAQQVGLVTSDYRYIIGNLD 248
            ..     ||      ||.::..:....:..|::...:..:....:|....|..:..|.||:.||.
Zfish   185 SV-----GNIVDPLEYRRIIEEMDRRQEKRFLIDCEVERINSILEQVVIAGKNSRGYHYILANLG 244

  Fly   249 WHTMDLEPYQHAGTNITGLRLVSPDSEQVQEVA---KALYESEEPFQNVSCPLTNSMALVYDGVQ 310
            :..|.|:.....|.||||.::::|||..||:..   :.|.|.|.| ::.|.||..:.||.:|.:.
Zfish   245 FTNMSLDKVFSGGANITGFQIINPDSPIVQQFLQRWERLDEREFP-ESRSSPLKYTSALTHDAIL 308

  Fly   311 LLAETYKHVNFRPVALS---------CNDDSAWDKGYTLVNYMKSLTLNGLTGPIRFDYEGLRTD 366
            ::||.::::..:.|.:|         .|....|.:|..:...:|.:.:.|:||.|:||..|.|::
Zfish   309 VIAEAFRYLRRQRVDISRRGSAGDCLANPAVPWSQGIDIERALKMVQVQGMTGNIQFDSFGRRSN 373

  Fly   367 FKLEVIELAVSGMQKIGQWSGEDGFQENRPAPAHSLEP----DMRSLVNKSFVVITAISEPYGML 427
            :.::|.|:...|.:|||.|:..:.|       .:.:|.    :..|:.|::.||.|.:..||.|.
Zfish   374 YTVDVYEMKPGGARKIGYWNEFEKF-------VYIVEQQVTNESSSVENRTIVVTTIMEAPYVMY 431

  Fly   428 KETSEKLEGNDQFEGFGIELIDELSKKLGFSYTWRLQEDNKYGGIDPKTGEWNGMLREIIDSRAD 492
            |....:|||||::||:.::|..|::|.:|..|...:..|.|||..||:|..||||:.|::..|||
Zfish   432 KRNYMQLEGNDRYEGYCVDLASEIAKHVGIKYKLSIVADGKYGARDPETKTWNGMVGELVYGRAD 496

  Fly   493 MGITDLTMTSERESGVDFTIPFMSLGIGILFRKPMKEPPKLFSFMSPFSGEVWLWLGLAYMGVSI 557
            :.:..||:|..||..:||:.|||||||.|:.:||.|..|.:|||:.|.:.|:|:.:..||:|||:
Zfish   497 IAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSV 561

  Fly   558 SMFVLGRLSPAEW---DNPYPCIEE------PTELENQFSFANCLWFSIGALLQQGSELAPKAYS 613
            .:|::.|.||.||   ||     ||      |.:..|.|...|.||||:||.:|||.:::|::.|
Zfish   562 VLFLVSRFSPYEWHLDDN-----EETKDPQTPPDPPNDFGIFNSLWFSLGAFMQQGCDISPRSLS 621

  Fly   614 TRAVAASWWFFTLILVSSYTANLAAFLTVESLVTPINDADDLSKNKGGVNYGAKIGGATFNFFKE 678
            .|.|...|||||||::||||||||||||||.:|:||..|:||:| :..:.||....|:|..||:.
Zfish   622 GRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAK-QTEIAYGTLDSGSTKEFFRR 685

  Fly   679 SNYPTYQRMYEFMRD-NPQYMTNTNQEGVDRVENS--NYAFLMESTTIEYITERR-CTLTQVGAL 739
            |....|::|:.:|:. .|.....|..:||.||..|  .:|||:|||..|||.:|: |...:||..
Zfish   686 SKIAVYEKMWSYMKSAEPSVFVKTTPDGVARVRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGN 750

  Fly   740 LDEKGYGIAMRKNWPYRDTLSQAVLEMQEQGLLTKMKTKWWQEKRGGGACSDADEDSGAVALEIS 804
            ||.||||:|..|....|..::.|||::.|||:|.|:|.|||.:|   |.|  ..:|||:....::
Zfish   751 LDSKGYGVATPKGSALRTPVNLAVLKLSEQGILDKLKNKWWYDK---GEC--GTKDSGSKVSLLT 810

  Fly   805 NL-------------GGVFLVMGVGSFFGIFV 823
            :|             ...|.|.|...|:.:|:
Zfish   811 HLTVLPTNISIYHKHHNEFPVAGFTFFWPLFI 842

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Grik	NP_001262788.1	PBP1_iGluR_Kainate	37..391	CDD:107377	93/378 (25%)
		ANF_receptor	53..374	CDD:279440	81/344 (24%)
		Periplasmic_Binding_Protein_Type_2	411..781	CDD:304360	170/382 (45%)
		Lig_chan	543..816	CDD:278489	123/298 (41%)
gria3a	XP_005165152.1	PBP1_iGluR_AMPA_GluR3	28..399	CDD:107382	95/405 (23%)
		ANF_receptor	39..382	CDD:279440	88/370 (24%)
		PBP2_iGluR_AMPA	415..797	CDD:270433	173/390 (44%)
		Lig_chan	547..810	CDD:278489	119/273 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591342
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.850