Protein Alignment Grik and gria2b

DIOPT Version :10

• Sequence 1: NP_001262788.1
• Gene: Grik / 42476
• FlyBaseID: FBgn0038840
• Length: 907
• Species: Drosophila melanogaster
• Sequence 2: XP_068069253.1
• Gene: gria2b / 170451
• ZFINID: ZDB-GENE-020125-4
• Length: 944
• Species: Danio rerio
• Alignment Length: 882
• Identity: 279/882 - (31%)
• Similarity: 444/882 - (50%)
• Gaps: 108/882 - (12%)

  Fly    73 SIEPGNSFETSKKLCKMLRQNLVAVFGPTSNLAARHAMSICDAKELPFLDTRWDF-GAQLPTINL 136
            ::|..|||..:...|....:.:.|:||.....:.....|.|....:.|:...:.. |.|...|.:
Zfish    63 NLEVANSFAVTNCFCSQFSRGVYAIFGFYDKKSVNTITSFCGTLHVSFITPSFPLDGNQQFIIQM 127

  Fly   137 HPHPATLGVALRDMVVALGWESFTIIYESGEYLPTVRELLQMYGTAGPTVTVRRYELD-LN-GN- 198
            .|   .:...|..::....|:.|..:|:|...|.|::.:|.       |...:::::. :| ||
Zfish   128 RP---DIKGPLLSLIEYYKWDKFAYLYDSDRGLTTLQVVLD-------TAAEKKWQVTAINVGNM 182

  Fly   199 --------YRNVLRRIRNADDFSFVVVGSMATLPEFFKQAQQVGLVTSDYRYIIGNLDWHTMDLE 255
                    ||::.:.:.|..:...::......:.:..:|...:|.....|.|||.||.:...||.
Zfish   183 KDERKDEAYRSLFQDLENKKERRVILDCEQDKVKDIMEQVITIGRHVKGYHYIIANLGFVDGDLS 247

  Fly   256 PYQHAGTNITGLRLVSPDSEQVQEVA---KALYESEEPFQNVSCPLTNSMALVYDGVQLLAETYK 317
            ..|:.|.|::|.::|..|...|.:..   :||.|.|.|  .....:..:.||.||.||::.|.::
Zfish   248 KIQYGGANVSGFQIVDFDDPLVSKFDQRWEALEEKEYP--GADSKIRYTSALTYDAVQVMTEAFR 310

  Fly   318 HVNFRPVALS---------CNDDSAWDKGYTLVNYMKSLTLNGLTGPIRFDYEGLRTDFKLEVIE 373
            :::.:.:.:|         .|....|.:|..:...:|.:.::||||.|:||..|.|.::.:.|:|
Zfish   311 YLHKQRIDISRRANNGDCLANPAVPWAQGVEIERALKQVRVDGLTGNIQFDQYGKRVNYTVNVME 375

  Fly   374 LAVSGMQKIGQWSGEDGFQENRPAPAHSLEP-DMRSLVNKSFVVITAISEPYGMLKETSEKLEGN 437
            |..:|..|||.|:..|.....:    ..|.| |...|.||:.:|.|.:..||.|||:.::....|
Zfish   376 LKSNGAVKIGYWNEVDKMVVTK----SDLFPNDTMGLENKTVIVTTILEAPYVMLKKNADLFMDN 436

  Fly   438 DQFEGFGIELIDELSKKLGFSYTWRLQEDNKYGGIDPKTGEWNGMLREIIDSRADMGITDLTMTS 502
            :::||:.::|..|::|..||.|..::..|.|||..|.:|..||||:.|::..:||:.:..||:|.
Zfish   437 ERYEGYCVDLAAEIAKHCGFKYQLKIVGDGKYGARDAETKIWNGMVGELVYGKADIAVAPLTITL 501

  Fly   503 ERESGVDFTIPFMSLGIGILFRKPMKEPPKLFSFMSPFSGEVWLWLGLAYMGVSISMFVLGRLSP 567
            .||..:||:.|||||||.|:.:||.|..|.:|||:.|.:.|:|:.:..||:|||:.:|::.|.||
Zfish   502 VREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSP 566

  Fly   568 AEWDNPYPCIEE-------PTELENQFSFANCLWFSIGALLQQGSELAPKAYSTRAVAASWWFFT 625
            .||..     ||       ..|..|:|...|.||||:||.::||.:::|::.|.|.|...|||||
Zfish   567 YEWHT-----EEYEDGQIQTNESTNEFGIFNSLWFSLGAFMRQGCDISPRSLSGRIVGGVWWFFT 626

  Fly   626 LILVSSYTANLAAFLTVESLVTPINDADDLSKNKGGVNYGAKIGGATFNFFKESNYPTYQRMYEF 690
            ||::||||||||||||||.:|:||..|:||:| :..:.||....|:|..||:.|....:.:|:.:
Zfish   627 LIIISSYTANLAAFLTVERMVSPIESAEDLAK-QTEIAYGTLDSGSTKEFFRRSKIALFDKMWTY 690

  Fly   691 MRD-NPQYMTNTNQEGVDRVENS--NYAFLMESTTIEYITERR-CTLTQVGALLDEKGYGIAMRK 751
            |:. .|.....|..|||.||..|  .||:|:|||..|||.:|: |...:||..||.||||||..|
Zfish   691 MKGAEPSVFVKTTAEGVMRVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPK 755

  Fly   752 NWPYRDTLSQAVLEMQEQGLLTKMKTKWWQEK----RGGGAC-------SDAD------------ 793
            ....|:.::.|||::.|||||.|:|.|||.:|    .|||..       ||..
Zfish   756 GSSLRNAVNLAVLKLNEQGLLDKLKNKWWYDKGECGSGGGDSKVSPREQSDGTPVNLAVLKLSEQ 820

  Fly   794 -------------------EDSGA----VALEISNLGGVFLVMGVGSFFGIFVSLLEMVLGVKER 835
                               :|||:    .||.:||:.|||.::..|....:.|:|:|.....:..
Zfish   821 GTLDKLKNKWWYDKGECGAKDSGSKEKTSALSLSNVAGVFYILVGGLGLAMLVALVEFCYKSRAE 885

  Fly   836 SDENQVSFKTELLDEIRFILQCS----GNTKAVKYPK 868
            :...:|:|...:..:.|..:..|    |...:.::||
Zfish   886 AKRMKVTFSDAMRSKARLSVTGSTGENGRVMSPEFPK 922

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Grik	NP_001262788.1	PBP1_iGluR_Kainate	35..395	CDD:380605	82/345 (24%)
		Periplasmic_Binding_Protein_Type_2	411..781	CDD:473866	165/380 (43%)
gria2b	XP_068069253.1	PBP1_iGluR_AMPA_GluR2	27..397	CDD:380612	82/345 (24%)
		PBP2_iGluR_AMPA	410..790	CDD:270433	167/385 (43%)